E2F2 (E2F transcription factor 2) - Rat Genome Database

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Gene: E2F2 (E2F transcription factor 2) Canis lupus familiaris
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Symbol: E2F2
Name: E2F transcription factor 2
RGD ID: 12360823
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); lens fiber cell apoptotic process (ortholog); regulation of cell cycle (ortholog); ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); COVID-19 (ortholog); Disease Progression (ortholog); FOUND IN nucleus (inferred); RNA polymerase II transcription regulator complex (inferred); transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor E2F2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,901,009 - 75,923,406 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,901,058 - 75,923,255 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,471,074 - 72,493,421 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,460,446 - 76,482,801 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,459,883 - 76,480,634 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,282,735 - 73,305,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,289,942 - 74,312,301 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,295,343 - 75,317,658 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
E2F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,901,009 - 75,923,406 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,901,058 - 75,923,255 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,471,074 - 72,493,421 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,460,446 - 76,482,801 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,459,883 - 76,480,634 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,282,735 - 73,305,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,289,942 - 74,312,301 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,295,343 - 75,317,658 (+)NCBIUU_Cfam_GSD_1.0
E2F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,505,212 - 23,531,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,506,438 - 23,531,233 (-)EnsemblGRCh38hg38GRCh38
GRCh37123,832,930 - 23,857,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,705,509 - 23,730,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 34123,578,227 - 23,603,019NCBI
Celera122,162,636 - 22,187,415 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef122,083,477 - 22,108,254 (-)NCBIHuRef
CHM1_1123,945,595 - 23,970,369 (-)NCBICHM1_1
T2T-CHM13v2.0123,339,773 - 23,365,799 (-)NCBIT2T-CHM13v2.0
E2f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,899,585 - 135,923,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4135,899,705 - 135,923,368 (+)EnsemblGRCm39 Ensembl
GRCm384136,172,274 - 136,196,057 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,172,394 - 136,196,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,728,309 - 135,751,972 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,444,470 - 135,466,790 (+)NCBIMGSCv36mm8
Celera4134,369,818 - 134,393,475 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.34NCBI
E2f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85153,682,789 - 153,706,087 (+)NCBIGRCr8
mRatBN7.25148,399,193 - 148,422,595 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,399,642 - 148,421,217 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05154,516,611 - 154,540,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,522,119 - 154,540,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,290,231 - 158,313,411 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5146,801,415 - 146,824,688 (+)NCBICelera
Cytogenetic Map5q36NCBI
E2f2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,494,919 - 3,518,487 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,498,077 - 3,518,033 (-)NCBIChiLan1.0ChiLan1.0
E2F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,410,482 - 203,436,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11202,513,407 - 202,539,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,696,695 - 22,722,840 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,683,291 - 23,707,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,683,293 - 23,707,951 (-)Ensemblpanpan1.1panPan2
E2f2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,893,125 - 42,912,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,719,253 - 8,737,763 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,719,243 - 8,739,811 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,377,924 - 81,398,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1681,377,922 - 81,398,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
E2F2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,146,567 - 109,171,540 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20109,146,587 - 109,168,093 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660337,158,767 - 7,183,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,135,470 - 8,157,731 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247648,132,283 - 8,158,190 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in E2F2
418 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 6 6 8 5
Below cutoff 5 22 6 6 6 12 5 6

Sequence


RefSeq Acc Id: ENSCAFT00000021059   ⟹   ENSCAFP00000019556
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,901,058 - 75,923,255 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046775   ⟹   ENSCAFP00000035980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,901,058 - 75,920,524 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027010   ⟹   ENSCAFP00845021254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl276,459,883 - 76,480,634 (+)Ensembl
RefSeq Acc Id: XM_005617814   ⟹   XP_005617871
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1275,901,009 - 75,923,406 (+)NCBI
Dog10K_Boxer_Tasha272,471,074 - 72,493,421 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038463178   ⟹   XP_038319106
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha272,475,423 - 72,493,421 (+)NCBI
RefSeq Acc Id: XM_038470766   ⟹   XP_038326694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1273,282,735 - 73,305,077 (+)NCBI
RefSeq Acc Id: XM_038470767   ⟹   XP_038326695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1273,287,078 - 73,305,077 (+)NCBI
RefSeq Acc Id: XM_038531630   ⟹   XP_038387558
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,295,343 - 75,317,658 (+)NCBI
RefSeq Acc Id: XM_038531631   ⟹   XP_038387559
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,299,671 - 75,317,658 (+)NCBI
RefSeq Acc Id: XM_038595862   ⟹   XP_038451790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,289,942 - 74,312,301 (+)NCBI
RefSeq Acc Id: XM_038595863   ⟹   XP_038451791
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,294,281 - 74,312,301 (+)NCBI
RefSeq Acc Id: XM_038659937   ⟹   XP_038515865
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0276,460,446 - 76,482,801 (+)NCBI
RefSeq Acc Id: XM_038659938   ⟹   XP_038515866
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0276,464,795 - 76,482,801 (+)NCBI
RefSeq Acc Id: XP_005617871   ⟸   XM_005617814
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NKC8 (UniProtKB/TrEMBL),   A0A8P0SR78 (UniProtKB/TrEMBL),   A0A8C0L1B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000019556   ⟸   ENSCAFT00000021059
RefSeq Acc Id: ENSCAFP00000035980   ⟸   ENSCAFT00000046775
RefSeq Acc Id: XP_038326694   ⟸   XM_038470766
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038326695   ⟸   XM_038470767
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451790   ⟸   XM_038595862
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451791   ⟸   XM_038595863
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038515865   ⟸   XM_038659937
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NKC8 (UniProtKB/TrEMBL),   A0A8P0SR78 (UniProtKB/TrEMBL),   A0A8C0L1B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515866   ⟸   XM_038659938
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L1B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319106   ⟸   XM_038463178
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L1B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387558   ⟸   XM_038531630
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L1B3 (UniProtKB/TrEMBL),   A0A8I3NKC8 (UniProtKB/TrEMBL),   A0A8P0SR78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387559   ⟸   XM_038531631
- Peptide Label: isoform X2
- UniProtKB: A0A8C0L1B3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845021254   ⟸   ENSCAFT00845027010
Promoters
RGD ID:13682609
Promoter ID:EPDNEW_C675
Type:single initiation site
Name:E2F2_1
Description:E2F transcription factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1275,901,139 - 75,901,199EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013273 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845015124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000046775.3 UniProtKB/TrEMBL
  ENSCAFT00845027010 ENTREZGENE
  ENSCAFT00845027010.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  6.10.250.540 UniProtKB/TrEMBL
InterPro E2F UniProtKB/TrEMBL
  E2F-DP_heterodim UniProtKB/TrEMBL
  E2F_CC-MB UniProtKB/TrEMBL
  E2F_WHTH_DNA-bd_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report cfa:100855664 UniProtKB/TrEMBL
NCBI Gene E2F2 ENTREZGENE
PANTHER PTHR12081 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR E2F2 UniProtKB/TrEMBL
Pfam E2F_CC-MB UniProtKB/TrEMBL
  E2F_TDP UniProtKB/TrEMBL
SMART E2F_TDP UniProtKB/TrEMBL
Superfamily-SCOP SSF144074 UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A8C0L1B3 ENTREZGENE
  A0A8I3NKC8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SR78 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40164 ENTREZGENE