YY1 (YY1 transcription factor) - Rat Genome Database

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Pathways
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Gene: YY1 (YY1 transcription factor) Canis lupus familiaris
Analyze
Symbol: YY1
Name: YY1 transcription factor
RGD ID: 12360152
Description: ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); camera-type eye morphogenesis (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; mTOR signaling pathway; Notch signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Diabetic Nephropathies (ortholog); FOUND IN Ino80 complex (ortholog); nuclear matrix (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcriptional repressor protein YY1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,539,511 - 68,572,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,539,353 - 68,568,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,058,331 - 68,091,508 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,823,410 - 68,856,669 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,823,416 - 68,851,926 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,485,332 - 68,518,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,551,498 - 68,584,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,948,873 - 68,982,099 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
B cell differentiation  (IEA)
camera-type eye morphogenesis  (IEA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to UV  (IEA)
chromatin remodeling  (IEA)
chromosome organization  (IEA)
DNA damage response  (IEA)
double-strand break repair via homologous recombination  (IEA)
gene expression  (IEA,ISO)
hemopoiesis  (IEA)
immunoglobulin heavy chain V-D-J recombination  (IEA)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of interferon-beta production  (IEA)
negative regulation of miRNA transcription  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of DNA repair  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of telomere maintenance in response to DNA damage  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of cell cycle  (IEA)
regulation of chromosome organization  (IEA)
regulation of DNA repair  (IEA)
regulation of DNA replication  (IEA)
regulation of DNA strand elongation  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of embryonic development  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to prostaglandin F  (ISO)
response to UV-C  (IEA)
RNA localization  (IEA,ISO)
spermatogenesis  (IEA)
telomere maintenance  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
YY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,539,511 - 68,572,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,539,353 - 68,568,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,058,331 - 68,091,508 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,823,410 - 68,856,669 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,823,416 - 68,851,926 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,485,332 - 68,518,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,551,498 - 68,584,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,948,873 - 68,982,099 (+)NCBIUU_Cfam_GSD_1.0
YY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,239,144 - 100,282,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,238,298 - 100,282,788 (+)EnsemblGRCh38hg38GRCh38
GRCh3714100,705,481 - 100,749,125 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,774,855 - 99,814,557 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,774,854 - 99,814,557NCBI
Celera1480,759,739 - 80,799,431 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,888,079 - 80,926,725 (+)NCBIHuRef
CHM1_114100,642,915 - 100,683,150 (+)NCBICHM1_1
T2T-CHM13v2.01494,472,191 - 94,515,818 (+)NCBIT2T-CHM13v2.0
Yy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,758,841 - 108,786,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,758,899 - 108,786,074 (+)EnsemblGRCm39 Ensembl
GRCm3812108,792,945 - 108,820,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,792,973 - 108,820,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,031,521 - 110,054,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,241,118 - 109,264,439 (+)NCBIMGSCv36mm8
Celera12110,029,534 - 110,052,930 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.58NCBI
Yy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,471,615 - 133,500,875 (+)NCBIGRCr8
mRatBN7.26127,706,739 - 127,736,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,707,596 - 127,732,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,830,843 - 127,855,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,125,889 - 128,150,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,484,792 - 127,509,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,702,443 - 132,726,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,702,448 - 132,727,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,872,505 - 141,896,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,132,419 - 133,156,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16133,138,605 - 133,162,873 (+)NCBI
Celera6125,273,530 - 125,282,803 (+)NCBICelera
Cytogenetic Map6q32NCBI
Yy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543821,341,374 - 21,377,674 (+)NCBIChiLan1.0ChiLan1.0
YY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,390,655 - 101,434,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,607,371 - 100,650,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,859,491 - 80,903,651 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,173,287 - 100,217,651 (+)NCBIpanpan1.1PanPan1.1panPan2
Yy1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,137,064 - 6,171,061 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366043,911,407 - 3,945,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,132,191 - 121,170,697 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,132,168 - 121,170,699 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,602,231 - 128,613,935 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,199,172 - 78,243,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,199,039 - 78,237,165 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,338,296 - 65,383,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,846,765 - 3,875,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,846,753 - 3,875,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in YY1
304 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 3 17 1 6 1 6 12 10 6
Low 2 5 5 5 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000028393   ⟹   ENSCAFP00000026407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl868,539,353 - 68,568,058 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007628   ⟹   ENSCAFP00845006029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl868,823,416 - 68,851,926 (+)Ensembl
RefSeq Acc Id: XM_038484197   ⟹   XP_038340125
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1868,485,332 - 68,518,533 (+)NCBI
RefSeq Acc Id: XM_038545711   ⟹   XP_038401639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0868,948,873 - 68,982,099 (+)NCBI
RefSeq Acc Id: XM_038609804   ⟹   XP_038465732
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0868,551,498 - 68,584,736 (+)NCBI
RefSeq Acc Id: XM_038674627   ⟹   XP_038530555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0868,823,410 - 68,856,669 (+)NCBI
RefSeq Acc Id: XM_849421   ⟹   XP_854514
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1868,539,511 - 68,572,796 (+)NCBI
Dog10K_Boxer_Tasha868,058,331 - 68,091,508 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_854514   ⟸   XM_849421
- UniProtKB: A0A8C0Q4Q1 (UniProtKB/TrEMBL),   A0A8I3MKF1 (UniProtKB/TrEMBL),   A0A8C0MED5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026407   ⟸   ENSCAFT00000028393
RefSeq Acc Id: XP_038340125   ⟸   XM_038484197
RefSeq Acc Id: XP_038465732   ⟸   XM_038609804
RefSeq Acc Id: XP_038530555   ⟸   XM_038674627
- UniProtKB: A0A8C0Q4Q1 (UniProtKB/TrEMBL),   A0A8I3MKF1 (UniProtKB/TrEMBL),   A0A8C0MED5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401639   ⟸   XM_038545711
- UniProtKB: A0A8C0MED5 (UniProtKB/TrEMBL),   A0A8C0Q4Q1 (UniProtKB/TrEMBL),   A0A8I3MKF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845006029   ⟸   ENSCAFT00845007628
Protein Domains
C2H2-type

Promoters
RGD ID:13684336
Promoter ID:EPDNEW_C2405
Type:initiation region
Name:YY1_1
Description:YY1 transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1868,539,494 - 68,539,554EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017894 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006453 UniProtKB/TrEMBL
  ENSCAFG00040001176 UniProtKB/TrEMBL
  ENSCAFG00845004246 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028393.6 UniProtKB/TrEMBL
  ENSCAFT00030011874.1 UniProtKB/TrEMBL
  ENSCAFT00030011900.1 UniProtKB/TrEMBL
  ENSCAFT00040002190.1 UniProtKB/TrEMBL
  ENSCAFT00845007628 ENTREZGENE
  ENSCAFT00845007628.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro YY1-like UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report cfa:611171 UniProtKB/TrEMBL
NCBI Gene YY1 ENTREZGENE
PANTHER TRANSCRIPTIONAL REPRESSOR PROTEIN YY UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PIRSF TF_Yin_yang UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0MED5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q4Q1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MKF1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:51693 ENTREZGENE