SEC61A1 (SEC61 translocon subunit alpha 1) - Rat Genome Database

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Gene: SEC61A1 (SEC61 translocon subunit alpha 1) Canis lupus familiaris
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Symbol: SEC61A1
Name: SEC61 translocon subunit alpha 1
RGD ID: 12357952
Description: ENCODES a protein that exhibits calcium channel activity (ortholog); ribosome binding (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN protein targeting to ER; cotranslational protein targeting to membrane (ortholog); endoplasmic reticulum organization (ortholog); ASSOCIATED WITH agammaglobulinemia (ortholog); Autosomal Dominant Tubulointerstitial Kidney Disease 5 (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN integral component of endoplasmic reticulum membrane; membrane (ortholog); rough endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: protein transport protein Sec61 subunit alpha; protein transport protein Sec61 subunit alpha isoform 1; sec61 alpha-1; sec61 homologue; SEC61 translocon alpha 1 subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,070,739 - 2,087,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,070,248 - 2,087,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,106,985 - 2,124,750 (+)NCBI
ROS_Cfam_1.0202,091,105 - 2,109,038 (+)NCBI
UMICH_Zoey_3.1201,812,164 - 1,829,894 (+)NCBI
UNSW_CanFamBas_1.0202,138,938 - 2,156,767 (+)NCBI
UU_Cfam_GSD_1.0202,099,082 - 2,117,009 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:1423609   PMID:14596596   PMID:18480044   PMID:21102557   PMID:21558796   PMID:32692975  


Genomics

Comparative Map Data
SEC61A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1202,070,739 - 2,087,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl202,070,248 - 2,087,789 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha202,106,985 - 2,124,750 (+)NCBI
ROS_Cfam_1.0202,091,105 - 2,109,038 (+)NCBI
UMICH_Zoey_3.1201,812,164 - 1,829,894 (+)NCBI
UNSW_CanFamBas_1.0202,138,938 - 2,156,767 (+)NCBI
UU_Cfam_GSD_1.0202,099,082 - 2,117,009 (+)NCBI
SEC61A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,051,641 - 128,071,683 (+)EnsemblGRCh38hg38GRCh38
GRCh383128,052,437 - 128,071,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373127,771,280 - 127,790,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,253,902 - 129,273,216 (+)NCBINCBI36hg18NCBI36
Build 343129,253,909 - 129,273,223NCBI
Celera3126,201,130 - 126,220,443 (+)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,151,693 - 125,170,962 (+)NCBIHuRef
CHM1_13127,734,421 - 127,753,735 (+)NCBICHM1_1
Sec61a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,480,589 - 88,495,782 (-)NCBIGRCm39mm39
GRCm39 Ensembl688,480,561 - 88,495,887 (-)Ensembl
GRCm38688,503,607 - 88,518,800 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,503,579 - 88,518,905 (-)EnsemblGRCm38mm10GRCm38
MGSCv37688,453,601 - 88,468,794 (-)NCBIGRCm37mm9NCBIm37
MGSCv36688,469,248 - 88,484,441 (-)NCBImm8
Celera690,445,389 - 90,460,590 (-)NCBICelera
Cytogenetic Map6D1NCBI
Sec61a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24120,973,519 - 120,987,871 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4120,960,626 - 120,987,925 (-)Ensembl
Rnor_6.04120,453,577 - 120,467,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,453,581 - 120,467,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04185,693,504 - 185,707,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,597,889 - 122,612,245 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14122,842,369 - 122,856,726 (-)NCBI
Celera4109,929,352 - 109,943,708 (-)NCBICelera
Cytogenetic Map4q34NCBI
Sec61a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,637,325 - 15,652,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,637,461 - 15,652,556 (-)NCBIChiLan1.0ChiLan1.0
SEC61A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,457,658 - 132,476,935 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,457,005 - 132,476,935 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03125,091,916 - 125,111,238 (+)NCBIMhudiblu_PPA_v0panPan3
Sec61a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,536,221 - 20,546,520 (-)NCBI
SpeTri2.0NW_004936798578,090 - 587,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEC61A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1372,254,464 - 72,365,493 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11372,254,462 - 72,276,484 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,737,470 - 79,751,229 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SEC61A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,977,101 - 52,994,766 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2252,976,872 - 52,992,039 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041113,361,009 - 113,378,787 (+)NCBIVero_WHO_p1.0
Sec61a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624961466,234 - 477,880 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 2 12 8 10 6
Low 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006576   ⟹   ENSCAFP00000006087
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl202,070,248 - 2,075,848 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000043404   ⟹   ENSCAFP00000037921
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl202,070,730 - 2,087,789 (+)Ensembl
RefSeq Acc Id: NM_001003315   ⟹   NP_001003315
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1202,070,739 - 2,087,790 (+)NCBI
Dog10K_Boxer_Tasha202,106,985 - 2,124,750 (+)NCBI
ROS_Cfam_1.0202,091,105 - 2,109,038 (+)NCBI
UMICH_Zoey_3.1201,812,164 - 1,829,894 (+)NCBI
UNSW_CanFamBas_1.0202,138,938 - 2,156,767 (+)NCBI
UU_Cfam_GSD_1.0202,099,082 - 2,117,009 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003315 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA30891 (Get FASTA)   NCBI Sequence Viewer  
  P38377 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003315   ⟸   NM_001003315
- Peptide Label: isoform 1
- UniProtKB: P38377 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000037921   ⟸   ENSCAFT00000043404
RefSeq Acc Id: ENSCAFP00000006087   ⟸   ENSCAFT00000006576


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004107 Ensembl
NCBI Gene SEC61A1 ENTREZGENE
UniProt P38377 ENTREZGENE
VGNC ID VGNC:49614 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-11 SEC61A1  SEC61 translocon subunit alpha 1  SEC61A1  SEC61 translocon alpha 1 subunit  Symbol and/or name change 19259463 PROVISIONAL
2019-04-23 SEC61A1  SEC61 translocon alpha 1 subunit    Sec61 translocon alpha 1 subunit  Symbol and/or name change 5135510 APPROVED