HTRA2 (HtrA serine peptidase 2) - Rat Genome Database

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Gene: HTRA2 (HtrA serine peptidase 2) Canis lupus familiaris
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Symbol: HTRA2
Name: HtrA serine peptidase 2
RGD ID: 12355387
Description: ENCODES a protein that exhibits serine-type peptidase activity (ortholog); INVOLVED IN adult locomotory behavior (ortholog); adult walking behavior (ortholog); ceramide metabolic process (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 8 (ortholog); Alzheimer's disease (ortholog); asphyxia neonatorum (ortholog); FOUND IN CD40 receptor complex (inferred); chromatin (inferred); cytoplasmic side of plasma membrane (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: protease serine 25; serine protease HTRA2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,610,408 - 48,613,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,610,408 - 48,613,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,252,304 - 48,255,295 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,469,859 - 49,472,851 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,467,050 - 49,472,864 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,487,009 - 48,490,000 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,553,751 - 48,556,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,111,429 - 49,114,422 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HTRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,610,408 - 48,613,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,610,408 - 48,613,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,252,304 - 48,255,295 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,469,859 - 49,472,851 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,467,050 - 49,472,864 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,487,009 - 48,490,000 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,553,751 - 48,556,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,111,429 - 49,114,422 (-)NCBIUU_Cfam_GSD_1.0
HTRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,529,405 - 74,533,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,529,596 - 74,533,350 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,756,532 - 74,760,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,610,040 - 74,614,191 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,668,186 - 74,672,098NCBI
Celera274,587,640 - 74,591,791 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,492,793 - 74,496,944 (+)NCBIHuRef
CHM1_1274,685,928 - 74,690,079 (+)NCBICHM1_1
T2T-CHM13v2.0274,537,971 - 74,542,122 (+)NCBIT2T-CHM13v2.0
Htra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,028,247 - 83,031,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,028,247 - 83,032,254 (-)EnsemblGRCm39 Ensembl
GRCm38683,051,266 - 83,054,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,051,266 - 83,055,273 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,001,260 - 83,004,565 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,016,940 - 83,020,229 (-)NCBIMGSCv36mm8
Celera685,033,853 - 85,037,160 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Htra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,114,631 - 117,117,793 (-)NCBIGRCr8
mRatBN7.24115,556,914 - 115,560,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,556,916 - 115,560,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,033,497 - 121,036,659 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,808,694 - 116,811,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,423,257 - 115,426,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,883,671 - 113,886,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,883,670 - 113,886,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,568,771 - 178,571,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,262,206 - 117,265,368 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,506,685 - 117,509,829 (-)NCBI
Celera4104,551,592 - 104,554,754 (-)NCBICelera
Cytogenetic Map4q34NCBI
Htra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,255,756 - 11,259,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,255,756 - 11,259,170 (-)NCBIChiLan1.0ChiLan1.0
HTRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,856,074 - 51,859,242 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,858,033 - 51,861,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,596,020 - 74,599,790 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,102,240 - 76,106,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,102,240 - 76,106,152 (+)Ensemblpanpan1.1panPan2
Htra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,992,054 - 9,996,178 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556741,718 - 749,090 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556741,718 - 746,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,516,500 - 68,519,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,516,666 - 68,520,025 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,688,452 - 71,690,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTRA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,745,436 - 32,749,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,743,708 - 32,748,577 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,422,108 - 79,425,985 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htra2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,980,362 - 28,983,869 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,980,375 - 28,983,719 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HTRA2
23 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 18 2 6 2 6 12 10 6
Low 5 4 4 4 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000013321   ⟹   ENSCAFP00000012325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1748,610,408 - 48,613,399 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060981   ⟹   ENSCAFP00000044425
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1748,610,413 - 48,613,399 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000084877   ⟹   ENSCAFP00000063651
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1748,610,408 - 48,613,399 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032660   ⟹   ENSCAFP00845025545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1749,467,050 - 49,472,864 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032722   ⟹   ENSCAFP00845025597
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1749,467,050 - 49,472,864 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032777   ⟹   ENSCAFP00845025650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1749,469,864 - 49,472,864 (-)Ensembl
RefSeq Acc Id: NM_001284460   ⟹   NP_001271389
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11748,610,408 - 48,613,399 (-)NCBI
Dog10K_Boxer_Tasha1748,252,304 - 48,255,295 (-)NCBI
ROS_Cfam_1.01749,469,859 - 49,472,851 (-)NCBI
UMICH_Zoey_3.11748,487,009 - 48,490,000 (-)NCBI
UNSW_CanFamBas_1.01748,553,751 - 48,556,744 (-)NCBI
UU_Cfam_GSD_1.01749,111,429 - 49,114,422 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001271389   ⟸   NM_001284460
- UniProtKB: Q45FF7 (UniProtKB/TrEMBL),   A0A8C0KK47 (UniProtKB/TrEMBL),   A0A8C0RNJ0 (UniProtKB/TrEMBL),   A0A8I3S3D5 (UniProtKB/TrEMBL),   A0A8P0PCD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000063651   ⟸   ENSCAFT00000084877
RefSeq Acc Id: ENSCAFP00000044425   ⟸   ENSCAFT00000060981
RefSeq Acc Id: ENSCAFP00000012325   ⟸   ENSCAFT00000013321
RefSeq Acc Id: ENSCAFP00845025545   ⟸   ENSCAFT00845032660
RefSeq Acc Id: ENSCAFP00845025597   ⟸   ENSCAFT00845032722
RefSeq Acc Id: ENSCAFP00845025650   ⟸   ENSCAFT00845032777
Protein Domains
PDZ   Peptidase S1

Promoters
RGD ID:13686301
Promoter ID:EPDNEW_C4371
Type:single initiation site
Name:HTRA2_1
Description:Canis lupus familiaris HtrA serine peptidase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11748,613,412 - 48,613,472EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008388 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019038 UniProtKB/TrEMBL
  ENSCAFG00040007737 UniProtKB/TrEMBL
  ENSCAFG00845018463 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013321.4 UniProtKB/TrEMBL
  ENSCAFT00000060981.2 UniProtKB/TrEMBL
  ENSCAFT00000084877.2 UniProtKB/TrEMBL
  ENSCAFT00030035055.1 UniProtKB/TrEMBL
  ENSCAFT00030035124.1 UniProtKB/TrEMBL
  ENSCAFT00040014411.1 UniProtKB/TrEMBL
  ENSCAFT00040014443.1 UniProtKB/TrEMBL
  ENSCAFT00845032660 ENTREZGENE
  ENSCAFT00845032660.1 UniProtKB/TrEMBL
  ENSCAFT00845032722.1 UniProtKB/TrEMBL
  ENSCAFT00845032777.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/TrEMBL
  2.40.10.120 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1C UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
KEGG Report cfa:475782 UniProtKB/TrEMBL
NCBI Gene HTRA2 ENTREZGENE
PANTHER SERINE PROTEASE FAMILY S1C HTRA-RELATED UniProtKB/TrEMBL
  SERINE PROTEASE HTRA2, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam PDZ_6 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
  Trypsin_2 UniProtKB/TrEMBL
PRINTS PROTEASES2C UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
UniProt A0A8C0KK47 ENTREZGENE
  A0A8C0NWS4_CANLF UniProtKB/TrEMBL
  A0A8C0RNJ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P2U2_CANLF UniProtKB/TrEMBL
  A0A8I3S3D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PCD1 ENTREZGENE, UniProtKB/TrEMBL
  Q45FF7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41836 ENTREZGENE