MYL6B (myosin light chain 6B) - Rat Genome Database

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Gene: MYL6B (myosin light chain 6B) Canis lupus familiaris
Analyze
Symbol: MYL6B (Ensembl: MYL6)
Name: myosin light chain 6B
RGD ID: 12354313
Description: ENCODES a protein that exhibits calcium ion binding (inferred); structural constituent of muscle (inferred); ASSOCIATED WITH genetic disease (ortholog); Keloid (ortholog); FOUND IN myosin II complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110472,415 - 476,738 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10472,515 - 476,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10535,915 - 541,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010481,070 - 486,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10481,463 - 489,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110458,530 - 464,414 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010701,626 - 707,492 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010825,656 - 831,542 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
genetic disease  (ISO)
Keloid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYL6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110472,415 - 476,738 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10472,515 - 476,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10535,915 - 541,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010481,070 - 486,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10481,463 - 489,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110458,530 - 464,414 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010701,626 - 707,492 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010825,656 - 831,542 (+)NCBIUU_Cfam_GSD_1.0
MYL6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,152,587 - 56,157,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,152,256 - 56,159,647 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,546,371 - 56,551,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,832,602 - 54,838,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera1256,198,479 - 56,203,915 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,585,256 - 53,590,830 (+)NCBIHuRef
CHM1_11256,513,584 - 56,519,154 (+)NCBICHM1_1
T2T-CHM13v2.01256,120,192 - 56,125,594 (+)NCBIT2T-CHM13v2.0
Myl6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,330,026 - 128,334,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,330,026 - 128,334,554 (-)EnsemblGRCm39 Ensembl
GRCm3810128,494,157 - 128,498,685 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,494,157 - 128,498,685 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,931,213 - 127,935,741 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,897,106 - 127,901,634 (-)NCBIMGSCv36mm8
Celera10130,886,257 - 130,890,611 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.77NCBI
Myl6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X44,450,733 - 44,451,711 (+)NCBIGRCr8
mRatBN7.2X40,572,012 - 40,572,991 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX41,884,439 - 41,885,417 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X45,351,761 - 45,352,739 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X43,036,349 - 43,037,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X43,831,778 - 43,833,044 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X44,137,223 - 44,138,007 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X62,058,731 - 62,059,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX41,236,615 - 41,237,881 (+)NCBICelera
Cytogenetic MapXq21NCBI
Myl6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,755,936 - 3,760,414 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,755,936 - 3,760,414 (+)NCBIChiLan1.0ChiLan1.0
MYL6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,174,424 - 38,180,021 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,171,192 - 38,176,751 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,757,712 - 32,763,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,008,519 - 33,013,816 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,008,519 - 33,013,816 (-)Ensemblpanpan1.1panPan2
Myl6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,303,346 - 58,307,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646562,844 - 566,882 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646562,854 - 566,894 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,556,061 - 21,558,758 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,554,351 - 21,558,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,255,205 - 23,259,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238506
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,090,775 - 52,098,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,885,609 - 193,891,947 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,850,374 - 11,853,904 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,850,368 - 11,854,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYL6B
20 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 3 5
Medium 2 5 22 6 6 6 6 1 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014117152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_843490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000000176   ⟹   ENSCAFP00000000155
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10472,515 - 476,719 (+)Ensembl
RefSeq Acc Id: XM_014117152   ⟹   XP_013972627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110472,785 - 476,738 (+)NCBI
Dog10K_Boxer_Tasha10536,288 - 540,243 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038487772   ⟹   XP_038343700
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110458,530 - 462,857 (+)NCBI
RefSeq Acc Id: XM_038487773   ⟹   XP_038343701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110458,903 - 462,857 (+)NCBI
RefSeq Acc Id: XM_038487774   ⟹   XP_038343702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110458,530 - 464,414 (+)NCBI
RefSeq Acc Id: XM_038549661   ⟹   XP_038405589
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010825,657 - 829,982 (+)NCBI
RefSeq Acc Id: XM_038549662   ⟹   XP_038405590
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010826,029 - 829,982 (+)NCBI
RefSeq Acc Id: XM_038549663   ⟹   XP_038405591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010825,656 - 831,542 (+)NCBI
RefSeq Acc Id: XM_038613628   ⟹   XP_038469556
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010701,626 - 705,945 (+)NCBI
RefSeq Acc Id: XM_038613629   ⟹   XP_038469557
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010701,999 - 705,945 (+)NCBI
RefSeq Acc Id: XM_038613630   ⟹   XP_038469558
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010701,626 - 707,492 (+)NCBI
RefSeq Acc Id: XM_038632731   ⟹   XP_038488659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha10535,915 - 541,802 (+)NCBI
RefSeq Acc Id: XM_038678993   ⟹   XP_038534921
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010481,070 - 485,396 (+)NCBI
RefSeq Acc Id: XM_038678994   ⟹   XP_038534922
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010481,443 - 485,396 (+)NCBI
RefSeq Acc Id: XM_038678995   ⟹   XP_038534923
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010481,070 - 486,960 (+)NCBI
RefSeq Acc Id: XM_843490   ⟹   XP_848583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110472,415 - 476,738 (+)NCBI
Dog10K_Boxer_Tasha10535,915 - 540,243 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_848583   ⟸   XM_843490
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013972627   ⟸   XM_014117152
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000155   ⟸   ENSCAFT00000000176
RefSeq Acc Id: XP_038343702   ⟸   XM_038487774
RefSeq Acc Id: XP_038343700   ⟸   XM_038487772
RefSeq Acc Id: XP_038343701   ⟸   XM_038487773
RefSeq Acc Id: XP_038469558   ⟸   XM_038613630
RefSeq Acc Id: XP_038469556   ⟸   XM_038613628
RefSeq Acc Id: XP_038469557   ⟸   XM_038613629
RefSeq Acc Id: XP_038534923   ⟸   XM_038678995
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038534921   ⟸   XM_038678993
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038534922   ⟸   XM_038678994
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038488659   ⟸   XM_038632731
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405591   ⟸   XM_038549663
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405589   ⟸   XM_038549661
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405590   ⟸   XM_038549662
- UniProtKB: A0A8C0LJI2 (UniProtKB/TrEMBL),   A0A8C0RL12 (UniProtKB/TrEMBL),   A0A8I3MZ86 (UniProtKB/TrEMBL),   A0A8I3N3G5 (UniProtKB/TrEMBL)
Protein Domains
EF-hand

Promoters
RGD ID:13684868
Promoter ID:EPDNEW_C2935
Type:single initiation site
Name:MYL6B_1
Description:myosin light chain 6B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110474,056 - 474,116EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000110 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015654 UniProtKB/TrEMBL
  ENSCAFG00040004246 UniProtKB/TrEMBL
  ENSCAFG00845006499 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000176.5 UniProtKB/TrEMBL
  ENSCAFT00030028820.1 UniProtKB/TrEMBL
  ENSCAFT00030028892.1 UniProtKB/TrEMBL
  ENSCAFT00040008123.1 UniProtKB/TrEMBL
  ENSCAFT00845011614.1 UniProtKB/TrEMBL
  ENSCAFT00845011694 ENTREZGENE
  ENSCAFT00845011694.1 UniProtKB/TrEMBL
  ENSCAFT00845011722.1 UniProtKB/TrEMBL
  ENSCAFT00845011774.1 UniProtKB/TrEMBL
  ENSCAFT00845011839.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report cfa:606992 UniProtKB/TrEMBL
NCBI Gene MYL6B ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN 1, 3 UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN 6B UniProtKB/TrEMBL
  MYOSIN LIGHT POLYPEPTIDE 6 UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C0LJI2 ENTREZGENE
  A0A8C0NTK3_CANLF UniProtKB/TrEMBL
  A0A8C0RL12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZ86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N3B7_CANLF UniProtKB/TrEMBL
  A0A8I3N3G5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N3H7_CANLF UniProtKB/TrEMBL
  A0A8I3RTG0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43546 ENTREZGENE