FBXO5 (F-box protein 5) - Rat Genome Database

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Gene: FBXO5 (F-box protein 5) Canis lupus familiaris
Analyze
Symbol: FBXO5
Name: F-box protein 5
RGD ID: 12347703
Description: ENCODES a protein that exhibits anaphase-promoting complex binding (inferred); molecular function inhibitor activity (inferred); protein kinase binding (inferred); INVOLVED IN microtubule polymerization (ortholog); negative regulation of meiotic nuclear division (ortholog); negative regulation of ubiquitin protein ligase activity (ortholog); ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 8 (ortholog); chromosome 6q24-q25 deletion syndrome (ortholog); FOUND IN cytoplasm (inferred); meiotic spindle (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box only protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,138,338 - 43,149,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,138,889 - 43,149,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha143,975,851 - 43,987,186 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0143,321,686 - 43,333,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl143,322,263 - 43,332,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1143,189,124 - 43,200,485 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,052,605 - 43,063,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0143,540,287 - 43,551,650 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
meiotic spindle  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)
spindle  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FBXO5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,138,338 - 43,149,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,138,889 - 43,149,297 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha143,975,851 - 43,987,186 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0143,321,686 - 43,333,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl143,322,263 - 43,332,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1143,189,124 - 43,200,485 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,052,605 - 43,063,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0143,540,287 - 43,551,650 (-)NCBIUU_Cfam_GSD_1.0
FBXO5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386152,970,535 - 152,983,579 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6152,970,519 - 152,983,579 (-)EnsemblGRCh38hg38GRCh38
GRCh376153,291,670 - 153,304,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366153,333,351 - 153,345,867 (-)NCBINCBI36Build 36hg18NCBI36
Build 346153,383,773 - 153,396,288NCBI
Celera6154,025,328 - 154,038,410 (-)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6150,854,447 - 150,867,531 (-)NCBIHuRef
CHM1_16153,555,576 - 153,568,660 (-)NCBICHM1_1
T2T-CHM13v2.06154,171,829 - 154,184,878 (-)NCBIT2T-CHM13v2.0
Fbxo5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39105,749,155 - 5,755,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl105,749,160 - 5,755,600 (-)EnsemblGRCm39 Ensembl
GRCm38105,799,158 - 5,805,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl105,799,160 - 5,805,600 (-)EnsemblGRCm38mm10GRCm38
MGSCv37104,541,076 - 4,547,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36104,541,076 - 4,546,998 (+)NCBIMGSCv36mm8
Celera105,733,112 - 5,739,409 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map101.91NCBI
Fbxo5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,601,412 - 44,607,781 (-)NCBIGRCr8
mRatBN7.2142,196,068 - 42,202,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,196,068 - 42,202,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx142,738,271 - 42,744,646 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0148,725,464 - 48,731,839 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,813,736 - 42,820,111 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,461,277 - 42,467,646 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,461,291 - 42,467,586 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0143,791,187 - 43,797,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4136,492,134 - 36,498,503 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1136,495,551 - 36,501,323 (-)NCBI
Celera137,863,352 - 37,869,721 (-)NCBICelera
Cytogenetic Map1q11NCBI
Fbxo5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554398,830,975 - 8,843,828 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554398,830,658 - 8,843,653 (+)NCBIChiLan1.0ChiLan1.0
FBXO5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25172,999,614 - 173,012,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16170,892,462 - 170,905,617 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06150,793,020 - 150,806,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16155,481,767 - 155,494,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6155,481,753 - 155,494,231 (-)Ensemblpanpan1.1panPan2
Fbxo5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946138,337,977 - 138,349,305 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364895,589,538 - 5,600,539 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364895,589,621 - 5,602,221 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl113,467,501 - 13,505,928 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1113,466,961 - 13,478,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,716,714 - 15,728,617 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11380,453,345 - 80,467,590 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1380,453,355 - 80,466,778 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604052,778,853 - 52,792,908 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247855,247,731 - 5,260,736 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247855,248,434 - 5,260,623 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FBXO5
85 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000000840   ⟹   ENSCAFP00000000768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl143,138,889 - 43,149,297 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000042996   ⟹   ENSCAFP00000038421
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl143,138,889 - 43,149,013 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845000177   ⟹   ENSCAFP00845000135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl143,322,263 - 43,332,336 (-)Ensembl
RefSeq Acc Id: XM_022418083   ⟹   XP_022273791
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1143,138,339 - 43,149,546 (-)NCBI
Dog10K_Boxer_Tasha143,975,851 - 43,987,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038465716   ⟹   XP_038321644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1143,189,124 - 43,200,050 (-)NCBI
RefSeq Acc Id: XM_038465717   ⟹   XP_038321645
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1143,189,124 - 43,200,485 (-)NCBI
RefSeq Acc Id: XM_038526358   ⟹   XP_038382286
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0143,540,287 - 43,551,215 (-)NCBI
RefSeq Acc Id: XM_038526359   ⟹   XP_038382287
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0143,540,287 - 43,551,650 (-)NCBI
RefSeq Acc Id: XM_038590671   ⟹   XP_038446599
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0143,052,605 - 43,063,502 (-)NCBI
RefSeq Acc Id: XM_038590672   ⟹   XP_038446600
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0143,052,605 - 43,063,915 (-)NCBI
RefSeq Acc Id: XM_038654480   ⟹   XP_038510408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0143,321,686 - 43,332,616 (-)NCBI
RefSeq Acc Id: XM_038654481   ⟹   XP_038510409
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0143,321,686 - 43,333,047 (-)NCBI
RefSeq Acc Id: XM_849747   ⟹   XP_854840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1143,138,338 - 43,149,007 (-)NCBI
Dog10K_Boxer_Tasha143,975,851 - 43,986,751 (-)NCBI
Sequence:
RefSeq Acc Id: XP_854840   ⟸   XM_849747
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSL1 (UniProtKB/TrEMBL),   A0A8C0SW44 (UniProtKB/TrEMBL),   A0A8I3MUM1 (UniProtKB/TrEMBL),   A0A8C0MZV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022273791   ⟸   XM_022418083
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MZV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000000768   ⟸   ENSCAFT00000000840
Ensembl Acc Id: ENSCAFP00000038421   ⟸   ENSCAFT00000042996
RefSeq Acc Id: XP_038321645   ⟸   XM_038465717
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038321644   ⟸   XM_038465716
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038446600   ⟸   XM_038590672
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038446599   ⟸   XM_038590671
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038510409   ⟸   XM_038654481
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038510408   ⟸   XM_038654480
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSL1 (UniProtKB/TrEMBL),   A0A8C0SW44 (UniProtKB/TrEMBL),   A0A8I3MUM1 (UniProtKB/TrEMBL),   A0A8C0MZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038382287   ⟸   XM_038526359
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038382286   ⟸   XM_038526358
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSL1 (UniProtKB/TrEMBL),   A0A8C0MZV2 (UniProtKB/TrEMBL),   A0A8C0SW44 (UniProtKB/TrEMBL),   A0A8I3MUM1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845000135   ⟸   ENSCAFT00845000177
Protein Domains
ZBR-type

Promoters
RGD ID:13682009
Promoter ID:EPDNEW_C77
Type:single initiation site
Name:FBXO5_1
Description:F-box protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1143,148,984 - 43,149,044EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000547 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009566 UniProtKB/TrEMBL
  ENSCAFG00040017250 UniProtKB/TrEMBL
  ENSCAFG00845000104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000840.4 UniProtKB/TrEMBL
  ENSCAFT00030017683.1 UniProtKB/TrEMBL
  ENSCAFT00040031955.1 UniProtKB/TrEMBL
  ENSCAFT00845000177 ENTREZGENE
  ENSCAFT00845000177.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.20.25.20 UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  FBX5_43 UniProtKB/TrEMBL
  ZF_ZBR UniProtKB/TrEMBL
NCBI Gene FBXO5 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 5 UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 5 AND 43 UniProtKB/TrEMBL
Pfam F-box UniProtKB/TrEMBL
  IBR_1 UniProtKB/TrEMBL
PROSITE ZF_ZBR UniProtKB/TrEMBL
Superfamily-SCOP SSF81383 UniProtKB/TrEMBL
UniProt A0A8C0KSL1 ENTREZGENE
  A0A8C0MZV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SW44 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MUM1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40787 ENTREZGENE