PSMF1 (proteasome inhibitor subunit 1) - Rat Genome Database

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Gene: PSMF1 (proteasome inhibitor subunit 1) Canis lupus familiaris
Analyze
Symbol: PSMF1
Name: proteasome inhibitor subunit 1
RGD ID: 12345537
Description: ENCODES a protein that exhibits endopeptidase inhibitor activity (inferred); proteasome binding (inferred); protein heterodimerization activity (inferred); INVOLVED IN negative regulation of proteasomal protein catabolic process (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proteasome (prosome, macropain) inhibitor subunit 1 (PI31); proteasome inhibitor PI31 subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,817,104 - 19,863,632 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2419,819,055 - 19,859,586 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2419,472,370 - 19,517,915 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02420,512,337 - 20,552,248 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2420,512,523 - 20,552,371 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12419,786,390 - 19,831,946 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,891,748 - 19,937,283 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,322,761 - 20,368,316 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PSMF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12419,817,104 - 19,863,632 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2419,819,055 - 19,859,586 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2419,472,370 - 19,517,915 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02420,512,337 - 20,552,248 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2420,512,523 - 20,552,371 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12419,786,390 - 19,831,946 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02419,891,748 - 19,937,283 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,322,761 - 20,368,316 (-)NCBIUU_Cfam_GSD_1.0
PSMF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38201,113,263 - 1,172,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl201,113,240 - 1,189,415 (+)EnsemblGRCh38hg38GRCh38
GRCh37201,093,906 - 1,152,890 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36201,041,906 - 1,096,426 (+)NCBINCBI36Build 36hg18NCBI36
Build 34201,047,244 - 1,095,971NCBI
Celera201,190,063 - 1,244,762 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef201,045,500 - 1,100,199 (+)NCBIHuRef
CHM1_1201,093,930 - 1,148,420 (+)NCBICHM1_1
T2T-CHM13v2.0201,160,211 - 1,219,464 (+)NCBIT2T-CHM13v2.0
Psmf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392151,557,982 - 151,586,114 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2151,557,732 - 151,586,106 (-)EnsemblGRCm39 Ensembl
GRCm382151,716,062 - 151,744,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2151,715,812 - 151,744,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv372151,541,798 - 151,567,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362151,407,503 - 151,432,734 (-)NCBIMGSCv36mm8
Celera2157,532,937 - 157,558,172 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Psmf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,695,744 - 160,720,915 (-)NCBIGRCr8
mRatBN7.23140,235,371 - 140,260,546 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,235,373 - 140,260,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,139,915 - 144,165,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,723,730 - 152,748,903 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,464,099 - 150,489,269 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,238,111 - 147,263,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,238,114 - 147,263,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03153,590,716 - 153,615,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,058,695 - 142,083,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3138,993,887 - 139,019,024 (-)NCBICelera
Cytogenetic Map3q41NCBI
Psmf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955596381,068 - 416,055 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955596381,080 - 414,307 (+)NCBIChiLan1.0ChiLan1.0
PSMF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,156,113 - 2,205,176 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1202,152,942 - 2,202,005 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0201,275,662 - 1,325,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1201,043,513 - 1,093,291 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl201,043,513 - 1,092,237 (+)Ensemblpanpan1.1panPan2
Psmf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,054,236 - 169,090,234 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648517,485,602 - 17,517,696 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648517,485,600 - 17,517,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1734,098,991 - 34,169,287 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11734,118,324 - 34,164,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21738,667,378 - 38,715,774 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,373,939 - 55,415,928 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl255,376,171 - 55,415,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660871,791,327 - 1,835,057 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247412,409,187 - 2,443,071 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247412,402,616 - 2,443,461 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PSMF1
458 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005634892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005634893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022409450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038432914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038571861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038571862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038571863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000010994   ⟹   ENSCAFP00000010190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2419,820,028 - 19,859,586 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080667   ⟹   ENSCAFP00000060800
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2419,819,055 - 19,859,586 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034391   ⟹   ENSCAFP00845026927
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2420,512,523 - 20,552,371 (-)Ensembl
RefSeq Acc Id: XM_005634892   ⟹   XP_005634949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12419,817,108 - 19,859,684 (-)NCBI
Dog10K_Boxer_Tasha2419,472,454 - 19,513,983 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005634893   ⟹   XP_005634950
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12419,817,104 - 19,859,492 (-)NCBI
Dog10K_Boxer_Tasha2419,472,370 - 19,513,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022409450   ⟹   XP_022265158
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12419,817,108 - 19,863,632 (-)NCBI
Dog10K_Boxer_Tasha2419,472,454 - 19,517,915 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038432914   ⟹   XP_038288842
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02420,512,337 - 20,552,248 (-)NCBI
RefSeq Acc Id: XM_038508575   ⟹   XP_038364503
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12419,786,390 - 19,827,805 (-)NCBI
RefSeq Acc Id: XM_038508576   ⟹   XP_038364504
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12419,786,444 - 19,828,013 (-)NCBI
RefSeq Acc Id: XM_038508577   ⟹   XP_038364505
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12419,786,444 - 19,831,946 (-)NCBI
RefSeq Acc Id: XM_038571861   ⟹   XP_038427789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02420,322,761 - 20,364,175 (-)NCBI
RefSeq Acc Id: XM_038571862   ⟹   XP_038427790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02420,322,845 - 20,364,383 (-)NCBI
RefSeq Acc Id: XM_038571863   ⟹   XP_038427791
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02420,322,845 - 20,368,316 (-)NCBI
RefSeq Acc Id: XM_038636114   ⟹   XP_038492042
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02419,891,748 - 19,933,138 (-)NCBI
RefSeq Acc Id: XM_038636115   ⟹   XP_038492043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02419,891,831 - 19,933,346 (-)NCBI
RefSeq Acc Id: XM_038636116   ⟹   XP_038492044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02419,891,831 - 19,937,283 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005634949   ⟸   XM_005634892
- Peptide Label: isoform X9
- UniProtKB: A0A8C0JTP9 (UniProtKB/TrEMBL),   A0A8C0MQ36 (UniProtKB/TrEMBL),   A0A8P0N992 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005634950   ⟸   XM_005634893
- Peptide Label: isoform X8
- UniProtKB: A0A8C0JR05 (UniProtKB/TrEMBL),   A0A8C0T7T9 (UniProtKB/TrEMBL),   A0A8P0P9N5 (UniProtKB/TrEMBL),   A0A8P0N992 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022265158   ⟸   XM_022409450
- Peptide Label: isoform X9
- UniProtKB: A0A8C0JTP9 (UniProtKB/TrEMBL),   A0A8C0MQ36 (UniProtKB/TrEMBL),   A0A8P0N992 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010190   ⟸   ENSCAFT00000010994
RefSeq Acc Id: ENSCAFP00000060800   ⟸   ENSCAFT00000080667
RefSeq Acc Id: XP_038364503   ⟸   XM_038508575
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038364505   ⟸   XM_038508577
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038364504   ⟸   XM_038508576
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038492042   ⟸   XM_038636114
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038492044   ⟸   XM_038636116
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038492043   ⟸   XM_038636115
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038288842   ⟸   XM_038432914
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038427789   ⟸   XM_038571861
- Peptide Label: isoform X6
- UniProtKB: A0A8C0JR05 (UniProtKB/TrEMBL),   A0A8C0T7T9 (UniProtKB/TrEMBL),   A0A8P0N992 (UniProtKB/TrEMBL),   A0A8P0P9N5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038427791   ⟸   XM_038571863
- Peptide Label: isoform X7
- UniProtKB: A0A8C0JTP9 (UniProtKB/TrEMBL),   A0A8C0MQ36 (UniProtKB/TrEMBL),   A0A8P0N992 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038427790   ⟸   XM_038571862
- Peptide Label: isoform X7
- UniProtKB: A0A8C0JTP9 (UniProtKB/TrEMBL),   A0A8C0MQ36 (UniProtKB/TrEMBL),   A0A8P0N992 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026927   ⟸   ENSCAFT00845034391
Protein Domains
PI31 proteasome regulator C-terminal   PI31 proteasome regulator N-terminal

Promoters
RGD ID:13687548
Promoter ID:EPDNEW_C5616
Type:initiation region
Name:PSMF1_1
Description:proteasome inhibitor subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12419,859,553 - 19,859,613EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006834 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006252 UniProtKB/TrEMBL
  ENSCAFG00040019809 UniProtKB/TrEMBL
  ENSCAFG00845019510 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010994.5 UniProtKB/TrEMBL
  ENSCAFT00000080667.2 UniProtKB/TrEMBL
  ENSCAFT00030011486.1 UniProtKB/TrEMBL
  ENSCAFT00030011529.1 UniProtKB/TrEMBL
  ENSCAFT00040036600.1 UniProtKB/TrEMBL
  ENSCAFT00040036667.1 UniProtKB/TrEMBL
  ENSCAFT00845034391.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1000.30 UniProtKB/TrEMBL
InterPro PI31-like UniProtKB/TrEMBL
  PI31_Prot_C UniProtKB/TrEMBL
  PI31_Prot_N UniProtKB/TrEMBL
KEGG Report cfa:477184 UniProtKB/TrEMBL
NCBI Gene PSMF1 ENTREZGENE
PANTHER PROTEASOME INHIBITOR PI31 SUBUNIT UniProtKB/TrEMBL
  PTHR13266 UniProtKB/TrEMBL
Pfam PI31_Prot_C UniProtKB/TrEMBL
  PI31_Prot_N UniProtKB/TrEMBL
UniProt A0A8C0JR05 ENTREZGENE
  A0A8C0JTP9 ENTREZGENE
  A0A8C0MQ36 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T7T9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P6M2_CANLF UniProtKB/TrEMBL
  A0A8P0N992 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P9N5 ENTREZGENE
UniProt Secondary A0A8P0P9N5 UniProtKB/TrEMBL
VGNC ID VGNC:45120 ENTREZGENE