AMDHD2 (amidohydrolase domain containing 2) - Rat Genome Database

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Gene: AMDHD2 (amidohydrolase domain containing 2) Canis lupus familiaris
Analyze
Symbol: AMDHD2
Name: amidohydrolase domain containing 2
RGD ID: 12341388
Description: ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (inferred); metal ion binding (inferred); INVOLVED IN amino sugar metabolic process (inferred); carbohydrate metabolic process (inferred); N-acetylglucosamine catabolic process (inferred); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; ASSOCIATED WITH epilepsy (ortholog); genetic disease (ortholog); idiopathic generalized epilepsy (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: N-acetylglucosamine-6-phosphate deacetylase; putative N-acetylglucosamine-6-phosphate deacetylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,509,793 - 38,519,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,748,187 - 39,758,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,819,036 - 38,828,935 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,819,043 - 38,830,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,504,196 - 38,514,092 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,476,804 - 38,486,701 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,952,889 - 38,962,784 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AMDHD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,509,793 - 38,519,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,748,187 - 39,758,083 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,819,036 - 38,828,935 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,819,043 - 38,830,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,504,196 - 38,514,092 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,476,804 - 38,486,701 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,952,889 - 38,962,784 (-)NCBIUU_Cfam_GSD_1.0
AMDHD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,520,371 - 2,531,417 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,520,357 - 2,531,422 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,570,372 - 2,581,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,510,428 - 2,519,733 (+)NCBINCBI36Build 36hg18NCBI36
Celera162,785,299 - 2,795,891 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,496,333 - 2,507,027 (+)NCBIHuRef
CHM1_1162,570,312 - 2,580,904 (+)NCBICHM1_1
T2T-CHM13v2.0162,542,493 - 2,553,539 (+)NCBIT2T-CHM13v2.0
Amdhd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,374,807 - 24,382,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,374,807 - 24,382,740 (-)EnsemblGRCm39 Ensembl
GRCm381724,155,833 - 24,163,733 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,155,833 - 24,163,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,292,800 - 24,300,700 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,883,455 - 23,891,359 (-)NCBIMGSCv36mm8
Celera1724,661,114 - 24,669,067 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.28NCBI
Amdhd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,692,136 - 13,700,632 (-)NCBIGRCr8
mRatBN7.21013,187,579 - 13,196,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,187,578 - 13,196,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,932,403 - 17,940,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,421,240 - 17,429,728 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,919,718 - 12,928,192 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,528,400 - 13,536,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,528,413 - 13,536,899 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,344,252 - 13,352,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,407,051 - 13,415,537 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,407,050 - 13,415,527 (-)NCBI
Celera1012,873,632 - 12,882,118 (-)NCBICelera
Cytogenetic Map10q12NCBI
Amdhd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,782,755 - 14,791,649 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,775,528 - 14,791,650 (-)NCBIChiLan1.0ChiLan1.0
AMDHD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,022,005 - 3,032,992 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,803,011 - 6,813,986 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,376,904 - 1,387,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,619,320 - 2,629,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,619,320 - 2,630,375 (+)Ensemblpanpan1.1panPan2
AMDHD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,522,163 - 39,532,995 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,523,076 - 39,532,590 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,706,973 - 42,716,475 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMDHD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,394,229 - 2,403,949 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,394,295 - 2,405,897 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,619,426 - 28,630,811 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amdhd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824271,884 - 282,866 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824273,036 - 282,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AMDHD2
62 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014114684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014114685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038540692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038540693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038604815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038604816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038669499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038669500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001316428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005327057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005360973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005395508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005428665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00845006939   ⟹   ENSCAFP00845005529
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl638,819,043 - 38,830,163 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006960   ⟹   ENSCAFP00845005549
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl638,819,043 - 38,830,163 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006984   ⟹   ENSCAFP00845005571
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl638,819,043 - 38,828,944 (-)Ensembl
RefSeq Acc Id: XM_014114684   ⟹   XP_013970159
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1638,509,793 - 38,519,709 (-)NCBI
Dog10K_Boxer_Tasha639,748,187 - 39,758,082 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014114685   ⟹   XP_013970160
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1638,509,793 - 38,514,923 (-)NCBI
Dog10K_Boxer_Tasha639,748,187 - 39,753,306 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038479433   ⟹   XP_038335361
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,504,196 - 38,514,091 (-)NCBI
RefSeq Acc Id: XM_038479434   ⟹   XP_038335362
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,504,196 - 38,509,315 (-)NCBI
RefSeq Acc Id: XM_038540692   ⟹   XP_038396620
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0638,952,889 - 38,962,783 (-)NCBI
RefSeq Acc Id: XM_038540693   ⟹   XP_038396621
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0638,952,889 - 38,958,009 (-)NCBI
RefSeq Acc Id: XM_038604815   ⟹   XP_038460743
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0638,476,804 - 38,486,700 (-)NCBI
RefSeq Acc Id: XM_038604816   ⟹   XP_038460744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0638,476,804 - 38,481,923 (-)NCBI
RefSeq Acc Id: XM_038669499   ⟹   XP_038525427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0638,819,036 - 38,828,934 (-)NCBI
RefSeq Acc Id: XM_038669500   ⟹   XP_038525428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0638,819,036 - 38,824,155 (-)NCBI
RefSeq Acc Id: XR_001316428
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1638,510,399 - 38,519,711 (-)NCBI
Dog10K_Boxer_Tasha639,748,782 - 39,758,083 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005327057
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,504,791 - 38,514,092 (-)NCBI
RefSeq Acc Id: XR_005360973
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0638,953,484 - 38,962,784 (-)NCBI
RefSeq Acc Id: XR_005395508
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0638,477,399 - 38,486,701 (-)NCBI
RefSeq Acc Id: XR_005428665
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0638,819,631 - 38,828,935 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013970159   ⟸   XM_014114684
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LQM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013970160   ⟸   XM_014114685
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_038335361   ⟸   XM_038479433
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038335362   ⟸   XM_038479434
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038460743   ⟸   XM_038604815
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460744   ⟸   XM_038604816
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038525427   ⟸   XM_038669499
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LQM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038525428   ⟸   XM_038669500
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038396620   ⟸   XM_038540692
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LQM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396621   ⟸   XM_038540693
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845005571   ⟸   ENSCAFT00845006984
RefSeq Acc Id: ENSCAFP00845005529   ⟸   ENSCAFT00845006939
RefSeq Acc Id: ENSCAFP00845005549   ⟸   ENSCAFT00845006960
Protein Domains
Amidohydrolase-related


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019360 UniProtKB/TrEMBL
  ENSCAFG00030001688 UniProtKB/TrEMBL
  ENSCAFG00040019543 UniProtKB/TrEMBL
  ENSCAFG00845003862 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000069702.2 UniProtKB/TrEMBL
  ENSCAFT00030003023.1 UniProtKB/TrEMBL
  ENSCAFT00040036175.1 UniProtKB/TrEMBL
  ENSCAFT00845006939.1 UniProtKB/TrEMBL
  ENSCAFT00845006960.1 UniProtKB/TrEMBL
  ENSCAFT00845006984 ENTREZGENE
  ENSCAFT00845006984.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  GlcNAc_6-P_deAcase UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
NCBI Gene AMDHD2 ENTREZGENE
PANTHER N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE UniProtKB/TrEMBL
  PTHR11113:SF14 UniProtKB/TrEMBL
Pfam Amidohydro_1 UniProtKB/TrEMBL
PIRSF NagA UniProtKB/TrEMBL
Superfamily-SCOP SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
UniProt A0A8C0LQM5 ENTREZGENE
  A0A8C0Z284_CANLF UniProtKB/TrEMBL
  A0A8I3MLJ5_CANLF UniProtKB/TrEMBL
  A0A8I3MNI7_CANLF UniProtKB/TrEMBL
  A0A8I3RT68_CANLF UniProtKB/TrEMBL