NEMF (nuclear export mediator factor) - Rat Genome Database

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Gene: NEMF (nuclear export mediator factor) Canis lupus familiaris
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Symbol: NEMF
Name: nuclear export mediator factor
RGD ID: 12340984
Description: ENCODES a protein that exhibits alpha-aminoacyl-tRNA binding (inferred); ribosomal large subunit binding (inferred); tRNA binding (inferred); INVOLVED IN CAT tailing (inferred); nuclear export (inferred); protein-containing complex assembly (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); genetic disease (ortholog); FOUND IN cytosolic ribosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear export mediator factor NEMF; SDCCAG1; serologically defined colon cancer antigen 1; serologically defined colon cancer antigen 1 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,364,664 - 26,411,475 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,364,838 - 26,411,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,113,773 - 26,165,138 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0826,537,351 - 26,588,734 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,542,548 - 26,588,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,192,975 - 26,244,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,266,156 - 26,317,640 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,583,882 - 26,635,227 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
cytosolic ribosome  (IEA,ISO)
RQC complex  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEMF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,364,664 - 26,411,475 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,364,838 - 26,411,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,113,773 - 26,165,138 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0826,537,351 - 26,588,734 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,542,548 - 26,588,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,192,975 - 26,244,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,266,156 - 26,317,640 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,583,882 - 26,635,227 (-)NCBIUU_Cfam_GSD_1.0
NEMF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381449,782,083 - 49,852,788 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1449,782,083 - 49,852,821 (-)EnsemblGRCh38hg38GRCh38
GRCh371450,248,801 - 50,319,506 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,320,282 - 49,389,289 (-)NCBINCBI36Build 36hg18NCBI36
Build 341449,320,282 - 49,389,289NCBI
Celera1430,118,228 - 30,186,686 (-)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,375,757 - 30,444,509 (-)NCBIHuRef
CHM1_11450,189,108 - 50,257,797 (-)NCBICHM1_1
T2T-CHM13v2.01443,987,877 - 44,058,011 (-)NCBIT2T-CHM13v2.0
Nemf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,358,315 - 69,403,975 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,357,296 - 69,403,939 (-)EnsemblGRCm39 Ensembl
GRCm381269,311,541 - 69,357,201 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,310,522 - 69,357,165 (-)EnsemblGRCm38mm10GRCm38
MGSCv371270,412,530 - 70,458,153 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,230,148 - 70,275,771 (-)NCBIMGSCv36mm8
Celera1270,409,762 - 70,455,395 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.78NCBI
Nemf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,527,690 - 93,571,863 (-)NCBIGRCr8
mRatBN7.2687,791,650 - 87,835,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,791,656 - 87,835,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,190,715 - 88,235,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,490,148 - 88,534,500 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,929,905 - 87,974,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,611,021 - 91,676,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06101,068,660 - 101,132,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,276,394 - 91,319,734 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera686,289,001 - 86,333,626 (-)NCBICelera
Cytogenetic Map6q24NCBI
Nemf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,855,749 - 12,900,702 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,855,655 - 12,901,673 (+)NCBIChiLan1.0ChiLan1.0
NEMF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21550,917,346 - 50,988,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,135,272 - 50,205,013 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,372,390 - 30,441,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,679,252 - 48,748,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,679,252 - 48,748,258 (-)Ensemblpanpan1.1panPan2
Nemf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,428,777 - 58,479,125 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936583209,813 - 255,131 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936583209,818 - 255,439 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEMF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,622,755 - 179,670,996 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,622,728 - 179,671,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21199,958,280 - 200,005,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEMF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,834,457 - 26,906,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2426,835,305 - 26,906,564 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605315,159,608 - 15,230,852 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nemf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,917,191 - 18,961,764 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473118,917,097 - 18,963,490 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NEMF
371 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 5 7
Low 5 5 12 6 6 6 6 6 7 8 3 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005623377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038608778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038608779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_846136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002629121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000022576   ⟹   ENSCAFP00000020962
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl826,364,838 - 26,411,424 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081194   ⟹   ENSCAFP00000061147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl826,365,280 - 26,411,424 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082012   ⟹   ENSCAFP00000063859
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl826,366,693 - 26,411,424 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083769   ⟹   ENSCAFP00000052289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl826,365,280 - 26,411,379 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087007   ⟹   ENSCAFP00000051317
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl826,365,280 - 26,411,424 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004353   ⟹   ENSCAFP00845003477
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl826,542,548 - 26,588,678 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004415   ⟹   ENSCAFP00845003531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl826,584,429 - 26,588,859 (-)Ensembl
RefSeq Acc Id: XM_005623377   ⟹   XP_005623434
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1826,364,664 - 26,411,475 (-)NCBI
Dog10K_Boxer_Tasha826,113,773 - 26,165,138 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038483203   ⟹   XP_038339131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1826,192,975 - 26,244,344 (-)NCBI
RefSeq Acc Id: XM_038483205   ⟹   XP_038339133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1826,192,975 - 26,244,344 (-)NCBI
RefSeq Acc Id: XM_038544654   ⟹   XP_038400582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0826,583,882 - 26,635,227 (-)NCBI
RefSeq Acc Id: XM_038544655   ⟹   XP_038400583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0826,583,882 - 26,635,227 (-)NCBI
RefSeq Acc Id: XM_038608778   ⟹   XP_038464706
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0826,266,156 - 26,317,640 (-)NCBI
RefSeq Acc Id: XM_038608779   ⟹   XP_038464707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0826,266,156 - 26,317,640 (-)NCBI
RefSeq Acc Id: XM_038673576   ⟹   XP_038529504
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0826,537,351 - 26,588,734 (-)NCBI
RefSeq Acc Id: XM_038673577   ⟹   XP_038529505
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0826,537,351 - 26,588,734 (-)NCBI
RefSeq Acc Id: XM_846136   ⟹   XP_851229
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1826,364,664 - 26,411,475 (-)NCBI
Dog10K_Boxer_Tasha826,113,773 - 26,165,138 (-)NCBI
Sequence:
RefSeq Acc Id: XP_851229   ⟸   XM_846136
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LBJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005623434   ⟸   XM_005623377
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LUQ6 (UniProtKB/TrEMBL),   A0A8I3MFD7 (UniProtKB/TrEMBL),   A0A8C0LBJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000051317   ⟸   ENSCAFT00000087007
RefSeq Acc Id: ENSCAFP00000052289   ⟸   ENSCAFT00000083769
RefSeq Acc Id: ENSCAFP00000063859   ⟸   ENSCAFT00000082012
RefSeq Acc Id: ENSCAFP00000020962   ⟸   ENSCAFT00000022576
RefSeq Acc Id: ENSCAFP00000061147   ⟸   ENSCAFT00000081194
RefSeq Acc Id: XP_038339133   ⟸   XM_038483205
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038339131   ⟸   XM_038483203
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038464707   ⟸   XM_038608779
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038464706   ⟸   XM_038608778
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038529505   ⟸   XM_038673577
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LBJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038529504   ⟸   XM_038673576
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LUQ6 (UniProtKB/TrEMBL),   A0A8I3MFD7 (UniProtKB/TrEMBL),   A0A8C0LBJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400583   ⟸   XM_038544655
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LBJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400582   ⟸   XM_038544654
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LBJ7 (UniProtKB/TrEMBL),   A0A8C0LUQ6 (UniProtKB/TrEMBL),   A0A8I3MFD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003531   ⟸   ENSCAFT00845004415
RefSeq Acc Id: ENSCAFP00845003477   ⟸   ENSCAFT00845004353
Promoters
RGD ID:13684195
Promoter ID:EPDNEW_C2263
Type:multiple initiation site
Name:NEMF_1
Description:nuclear export mediator factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1826,411,433 - 26,411,493EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014226 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000296 UniProtKB/TrEMBL
  ENSCAFG00040002751 UniProtKB/TrEMBL
  ENSCAFG00845002470 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000081194.2 UniProtKB/TrEMBL
  ENSCAFT00000104743.1 UniProtKB/TrEMBL
  ENSCAFT00030000482.1 UniProtKB/TrEMBL
  ENSCAFT00040005235.1 UniProtKB/TrEMBL
  ENSCAFT00040005279.1 UniProtKB/TrEMBL
  ENSCAFT00040005337.1 UniProtKB/TrEMBL
  ENSCAFT00845004353 ENTREZGENE
  ENSCAFT00845004353.1 UniProtKB/TrEMBL
  ENSCAFT00845004415.1 UniProtKB/TrEMBL
Gene3D-CATH ibrinogen binding protein from staphylococcus aureus domain UniProtKB/TrEMBL
InterPro NFACT-C UniProtKB/TrEMBL
  NFACT_RNA-bd UniProtKB/TrEMBL
KEGG Report cfa:490678 UniProtKB/TrEMBL
NCBI Gene NEMF ENTREZGENE
PANTHER NUCLEAR EXPORT MEDIATOR FACTOR NEMF UniProtKB/TrEMBL
  NUCLEAR EXPORT MEDIATOR FACTOR NEMF UniProtKB/TrEMBL
Pfam NFACT-C UniProtKB/TrEMBL
  NFACT-R_1 UniProtKB/TrEMBL
  NFACT_N UniProtKB/TrEMBL
UniProt A0A8C0LBJ7 ENTREZGENE
  A0A8C0LUQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PZ79_CANLF UniProtKB/TrEMBL
  A0A8C0QB45_CANLF UniProtKB/TrEMBL
  A0A8I3MFD7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MLT0_CANLF UniProtKB/TrEMBL
  A0A8P0PM90_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43741 ENTREZGENE