SARDH (sarcosine dehydrogenase) - Rat Genome Database

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Gene: SARDH (sarcosine dehydrogenase) Canis lupus familiaris
Analyze
Symbol: SARDH
Name: sarcosine dehydrogenase
RGD ID: 12339319
Description: ENCODES a protein that exhibits flavin adenine dinucleotide binding (ortholog); folic acid binding (ortholog); sarcosine dehydrogenase activity (ortholog); INVOLVED IN tetrahydrofolate interconversion (ortholog); PARTICIPATES IN choline metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Ehlers-Danlos syndrome classic type 1 (ortholog); Hypoxia (ortholog); sarcosinemia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sarcosine dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,030,397 - 50,093,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,310,923 - 49,374,527 (-)NCBI
ROS_Cfam_1.0950,904,459 - 50,967,629 (-)NCBI
UMICH_Zoey_3.1949,665,765 - 49,728,991 (-)NCBI
UNSW_CanFamBas_1.0950,007,753 - 50,071,562 (-)NCBI
UU_Cfam_GSD_1.0950,086,168 - 50,149,420 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA,ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

Genomics

Comparative Map Data
SARDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,030,397 - 50,093,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,310,923 - 49,374,527 (-)NCBI
ROS_Cfam_1.0950,904,459 - 50,967,629 (-)NCBI
UMICH_Zoey_3.1949,665,765 - 49,728,991 (-)NCBI
UNSW_CanFamBas_1.0950,007,753 - 50,071,562 (-)NCBI
UU_Cfam_GSD_1.0950,086,168 - 50,149,420 (-)NCBI
SARDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9133,663,560 - 133,739,955 (-)EnsemblGRCh38hg38GRCh38
GRCh389133,663,074 - 133,739,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,528,682 - 136,605,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,518,503 - 135,594,863 (-)NCBINCBI36hg18NCBI36
Build 349133,558,235 - 133,634,596NCBI
Celera9107,075,562 - 107,151,924 (-)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9106,029,059 - 106,104,804 (-)NCBIHuRef
CHM1_19136,678,641 - 136,754,578 (-)NCBICHM1_1
Sardh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,078,405 - 27,138,344 (-)NCBIGRCm39mm39
GRCm39 Ensembl227,078,405 - 27,138,349 (-)Ensembl
GRCm38227,188,393 - 27,248,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,188,393 - 27,248,337 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,044,902 - 27,102,332 (-)NCBIGRCm37mm9NCBIm37
MGSCv36227,011,391 - 27,068,821 (-)NCBImm8
Celera226,892,296 - 26,949,897 (-)NCBICelera
Cytogenetic Map2A3NCBI
Sardh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,510,553 - 10,575,342 (-)NCBI
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Celera35,308,395 - 5,369,033 (-)NCBICelera
Cytogenetic Map3p12NCBI
Sardh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,933,918 - 2,976,931 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,933,918 - 2,975,645 (-)NCBIChiLan1.0ChiLan1.0
SARDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19133,398,806 - 133,473,642 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,398,806 - 133,473,642 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09104,786,774 - 104,864,480 (-)NCBIMhudiblu_PPA_v0panPan3
Sardh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,077,144 - 200,131,802 (-)NCBI
SpeTri2.0NW_0049366693,244,302 - 3,297,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,228,838 - 273,295,104 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,230,357 - 273,295,170 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,204,192 - 307,268,081 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SARDH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,397,312 - 4,469,890 (+)NCBI
ChlSab1.1 Ensembl124,397,539 - 4,469,562 (+)Ensembl
Vero_WHO_p1.0NW_023666058519,221 - 596,979 (-)NCBI
Sardh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247602,030,835 - 2,070,517 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 6 2 5 9 2
Low 5 6 6 4 3 7 8 1 4
Below cutoff 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005625152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038486998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038548838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038548840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038612773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038612774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038678069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_548398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002630198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005331129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005364815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005399247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005432589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000031482   ⟹   ENSCAFP00000029306
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000075276   ⟹   ENSCAFP00000061785
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081464   ⟹   ENSCAFP00000049003
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl950,033,775 - 50,091,553 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090422   ⟹   ENSCAFP00000064202
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl950,031,183 - 50,091,553 (-)Ensembl
RefSeq Acc Id: XM_005625152   ⟹   XP_005625209
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1950,030,397 - 50,093,554 (-)NCBI
Dog10K_Boxer_Tasha949,310,923 - 49,374,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038486997   ⟹   XP_038342925
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1949,665,765 - 49,728,988 (-)NCBI
RefSeq Acc Id: XM_038486998   ⟹   XP_038342926
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1949,665,765 - 49,728,988 (-)NCBI
RefSeq Acc Id: XM_038548838   ⟹   XP_038404766
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0950,086,168 - 50,149,417 (-)NCBI
RefSeq Acc Id: XM_038548840   ⟹   XP_038404768
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0950,086,168 - 50,149,417 (-)NCBI
RefSeq Acc Id: XM_038612773   ⟹   XP_038468701
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0950,007,753 - 50,071,559 (-)NCBI
RefSeq Acc Id: XM_038612774   ⟹   XP_038468702
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0950,007,753 - 50,071,559 (-)NCBI
RefSeq Acc Id: XM_038678068   ⟹   XP_038533996
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0950,904,459 - 50,967,624 (-)NCBI
RefSeq Acc Id: XM_038678069   ⟹   XP_038533997
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0950,904,459 - 50,967,623 (-)NCBI
RefSeq Acc Id: XM_548398   ⟹   XP_548398
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1950,030,397 - 50,093,553 (-)NCBI
Dog10K_Boxer_Tasha949,310,923 - 49,374,524 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002630198
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1950,032,787 - 50,093,556 (-)NCBI
Dog10K_Boxer_Tasha949,313,761 - 49,374,527 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005331129
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1949,668,601 - 49,728,991 (-)NCBI
RefSeq Acc Id: XR_005364815
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0950,089,006 - 50,149,420 (-)NCBI
RefSeq Acc Id: XR_005399247
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0950,010,610 - 50,071,562 (-)NCBI
RefSeq Acc Id: XR_005432589
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0950,907,281 - 50,967,629 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_548398   ⟸   XM_548398
- UniProtKB: E2R5G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005625209   ⟸   XM_005625152
- UniProtKB: E2R5G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000029306   ⟸   ENSCAFT00000031482
RefSeq Acc Id: ENSCAFP00000064202   ⟸   ENSCAFT00000090422
RefSeq Acc Id: ENSCAFP00000061785   ⟸   ENSCAFT00000075276
RefSeq Acc Id: ENSCAFP00000049003   ⟸   ENSCAFT00000081464
RefSeq Acc Id: XP_038342926   ⟸   XM_038486998
RefSeq Acc Id: XP_038342925   ⟸   XM_038486997
RefSeq Acc Id: XP_038468702   ⟸   XM_038612774
RefSeq Acc Id: XP_038468701   ⟸   XM_038612773
RefSeq Acc Id: XP_038533996   ⟸   XM_038678068
RefSeq Acc Id: XP_038533997   ⟸   XM_038678069
RefSeq Acc Id: XP_038404768   ⟸   XM_038548840
RefSeq Acc Id: XP_038404766   ⟸   XM_038548838
Protein Domains
DAO   FAO_M   GCV_T   GCV_T_C

Promoters
RGD ID:13684775
Promoter ID:EPDNEW_C2843
Type:multiple initiation site
Name:SARDH_1
Description:sarcosine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C2844  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1950,093,406 - 50,093,466EPDNEW
RGD ID:13684777
Promoter ID:EPDNEW_C2844
Type:single initiation site
Name:SARDH_2
Description:sarcosine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C2843  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1950,093,583 - 50,093,643EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019794 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000029306 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000049003 UniProtKB/TrEMBL
  ENSCAFP00000061785 UniProtKB/TrEMBL
  ENSCAFP00000064202 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031482 UniProtKB/TrEMBL
  ENSCAFT00000075276 UniProtKB/TrEMBL
  ENSCAFT00000081464 UniProtKB/TrEMBL
  ENSCAFT00000090422 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.120 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro FAD-dep_OxRdtase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAO_M UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
  GCV_T_N UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/TrEMBL
KEGG Report cfa:491277 UniProtKB/TrEMBL
NCBI Gene SARDH ENTREZGENE
Pfam DAO UniProtKB/TrEMBL
  FAO_M UniProtKB/TrEMBL
  GCV_T UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
Superfamily-SCOP SSF101790 UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A5F4C478_CANLF UniProtKB/TrEMBL
  A0A5F4DAD5_CANLF UniProtKB/TrEMBL
  A0A5F4DBS7_CANLF UniProtKB/TrEMBL
  E2R5G7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45867 ENTREZGENE