OR6B1 (olfactory receptor family 6 subfamily B member 1) - Rat Genome Database

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Gene: OR6B1 (olfactory receptor family 6 subfamily B member 1) Canis lupus familiaris
Analyze
Symbol: OR6B1
Name: olfactory receptor family 6 subfamily B member 1
RGD ID: 12339101
Description: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: olfactory receptor 6B1; olfactory receptor OR0334; olfactory receptor, family 6, subfamily B, member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,884,765 - 5,885,780 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,884,854 - 5,885,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,931,577 - 6,932,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0165,737,935 - 5,738,861 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,737,935 - 5,738,861 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1165,679,240 - 5,680,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,536,052 - 5,536,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,605,251 - 5,606,177 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:21846747   PMID:22301074  


Genomics

Comparative Map Data
OR6B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,884,765 - 5,885,780 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,884,854 - 5,885,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,931,577 - 6,932,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0165,737,935 - 5,738,861 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,737,935 - 5,738,861 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1165,679,240 - 5,680,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,536,052 - 5,536,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,605,251 - 5,606,177 (-)NCBIUU_Cfam_GSD_1.0
OR6B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387144,000,320 - 144,008,793 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7144,000,320 - 144,008,793 (+)EnsemblGRCh38hg38GRCh38
GRCh377143,697,413 - 143,705,886 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,332,023 - 143,332,958 (+)NCBINCBI36Build 36hg18NCBI36
Build 347143,138,737 - 143,139,673NCBI
Celera7138,334,371 - 138,335,306 (+)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7137,900,558 - 137,901,493 (+)NCBIHuRef
CHM1_17143,638,436 - 143,639,371 (+)NCBICHM1_1
T2T-CHM13v2.07145,280,679 - 145,289,168 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27143,039,260 - 143,040,195 (+)NCBI
Or6b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,811,350 - 42,815,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,811,318 - 42,816,450 (+)EnsemblGRCm39 Ensembl
GRCm38642,834,416 - 42,838,882 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,834,384 - 42,839,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,787,882 - 42,788,817 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,767,490 - 42,768,425 (+)NCBIMGSCv36mm8
Celera642,783,845 - 42,784,780 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.93NCBI
Or6b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,800,004 - 72,800,939 (+)NCBIGRCr8
mRatBN7.2471,799,982 - 71,800,917 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,796,561 - 71,802,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,787,023 - 76,787,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0472,700,246 - 72,701,181 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0471,092,690 - 71,093,625 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0472,428,128 - 72,429,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,428,128 - 72,429,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,332,490 - 72,333,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,124,552 - 137,125,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,735,503 - 70,736,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1471,011,632 - 71,012,568 (+)NCBI
Celera466,749,969 - 66,750,904 (+)NCBICelera
Cytogenetic Map4q24NCBI
LOC102004170
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955491349,421 - 350,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955491349,180 - 350,455 (+)NCBIChiLan1.0ChiLan1.0
LOC100978153
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,715,742 - 180,724,213 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,725,999 - 32,734,470 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,860,879 - 135,861,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17148,350,201 - 148,351,235 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7148,350,263 - 148,351,216 (+)Ensemblpanpan1.1panPan2
LOC101966817
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511811,678,661 - 11,695,658 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365271,212,800 - 1,213,735 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365271,212,739 - 1,213,771 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110258605
(Sus scrofa - pig)		 No map positions available.
LOC103227150
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,750,372 - 112,751,887 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,750,546 - 112,751,481 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660729,519,305 - 9,520,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701679
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480010,985,545 - 10,986,480 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480010,985,545 - 10,986,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OR6B1
8 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000005658   ⟹   ENSCAFP00000005238
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl165,884,854 - 5,885,780 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845023999   ⟹   ENSCAFP00845018848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl165,737,935 - 5,738,861 (-)Ensembl
RefSeq Acc Id: NM_001388564   ⟹   NP_001375493
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha166,931,577 - 6,932,503 (-)NCBI
ROS_Cfam_1.0165,737,935 - 5,738,861 (-)NCBI
UMICH_Zoey_3.1165,679,240 - 5,680,166 (-)NCBI
UNSW_CanFamBas_1.0165,536,052 - 5,536,978 (-)NCBI
UU_Cfam_GSD_1.0165,605,251 - 5,606,177 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001375493 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEN80201 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000005238.3
  ENSCAFP00845018848
  ENSCAFP00845018848.1
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000005238   ⟸   ENSCAFT00000005658
RefSeq Acc Id: NP_001375493   ⟸   NM_001388564
- UniProtKB: G3FJA5 (UniProtKB/TrEMBL),   A0A8P0S9A9 (UniProtKB/TrEMBL),   F1PGN1 (UniProtKB/TrEMBL),   A0A8C0R4T8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845018848   ⟸   ENSCAFT00845023999
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003517 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845013477 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005658.4 UniProtKB/TrEMBL
  ENSCAFT00845023999 ENTREZGENE
  ENSCAFT00845023999.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene OR6B1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C0R4T8 ENTREZGENE
  A0A8P0S9A9 ENTREZGENE, UniProtKB/TrEMBL
  F1PGN1 ENTREZGENE, UniProtKB/TrEMBL
  G3FJA5 ENTREZGENE
UniProt Secondary G3FJA5 UniProtKB/TrEMBL
VGNC ID VGNC:96988 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-11 OR6B1  olfactory receptor family 6 subfamily B member 1  OR6B1  olfactory receptor, family 6, subfamily B, member 1  Symbol and/or name change 5135510 APPROVED