GP1BB (glycoprotein Ib platelet subunit beta)

Gene: GP1BB (glycoprotein Ib platelet subunit beta) Canis lupus familiaris

Analyze

Symbol:

GP1BB

Name:

glycoprotein Ib platelet subunit beta

RGD ID:

12338828

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN blood coagulation, intrinsic pathway (ortholog); megakaryocyte development (ortholog); positive regulation of platelet activation (ortholog); PARTICIPATES IN platelet aggregation pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); Bernard-Soulier syndrome (ortholog); FOUND IN glycoprotein Ib-IX-V complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glycoprotein Ib (platelet), beta polypeptide; glycoprotein Ib platelet beta subunit; platelet glycoprotein Ib beta chain

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

NCBI Annotation Information:

Annotation category: not annotated on reference assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	29,567,437 - 29,568,627 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	29,528,366 - 29,568,522 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	29,524,678 - 29,525,676 (-)	NCBI		Dog10K_Boxer_Tasha

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

Bernard-Soulier syndrome (ISO)

Bernard-Soulier Syndrome, Type B (ISO)

carotid artery thrombosis (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

chromosome 22q11.2 microduplication syndrome (ISO)

congenital heart disease (ISO)

Craniofacial Abnormalities (ISO)

DiGeorge syndrome (ISO)

epilepsy (ISO)

genetic disease (ISO)

hemorrhagic disease (ISO)

immunodeficiency 51 (ISO)

intellectual disability (ISO)

juvenile rheumatoid arthritis (ISO)

megacolon (ISO)

Mesenteric Ischemia (ISO)

Neurodevelopmental Disorders (ISO)

Polyarteritis Nodosa, Childhood-Onset (ISO)

polycystic ovary syndrome (ISO)

primary immunodeficiency disease (ISO)

schizophrenia (ISO)

thrombocytopenia (ISO)

Thromboembolism (ISO)

velocardiofacial syndrome (ISO)

Venous Thrombosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

blood coagulation, intrinsic pathway (ISO)

hemostasis (IEA)

megakaryocyte development (ISO)

positive regulation of platelet activation (ISO)

release of sequestered calcium ion into cytosol (ISO)

Cellular Component

glycoprotein Ib-IX-V complex (ISO)

membrane (IEA)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

platelet aggregation pathway (ISO)

References

Genomics

Comparative Map Data

GP1BB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	29,567,437 - 29,568,627 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	29,528,366 - 29,568,522 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	29,524,678 - 29,525,676 (-)	NCBI		Dog10K_Boxer_Tasha

GP1BB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	19,723,539 - 19,724,771 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	19,723,539 - 19,724,771 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	19,711,062 - 19,712,294 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	18,091,066 - 18,092,297 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	18,085,619 - 18,086,848	NCBI
Celera	22	3,563,179 - 3,564,410 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21	ENTREZGENE
HuRef	22	3,331,052 - 3,332,283 (+)	NCBI		HuRef
CHM1_1	22	19,710,630 - 19,711,861 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	20,100,330 - 20,101,562 (+)	NCBI		T2T-CHM13v2.0

Gp1bb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	18,439,069 - 18,441,153 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	18,439,067 - 18,441,153 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	18,620,319 - 18,622,403 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	18,620,317 - 18,622,403 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	18,620,412 - 18,622,496 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	18,533,882 - 18,535,966 (-)	NCBI		MGSCv36	mm8
Celera	16	19,194,412 - 19,196,496 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	11.53	NCBI

Gp1bb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	95,882,561 - 95,883,738 (+)	NCBI		GRCr8
mRatBN7.2	11	82,378,216 - 82,379,393 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	82,378,199 - 82,379,392 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	91,107,863 - 91,109,040 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	83,769,069 - 83,770,246 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	82,822,585 - 82,823,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	86,520,992 - 86,522,169 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	86,520,992 - 86,522,169 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	89,620,984 - 89,622,161 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	84,369,795 - 84,370,972 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	84,405,789 - 84,411,568 (+)	NCBI
Celera	11	81,154,033 - 81,155,210 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

Gp1bb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	18,359,664 - 18,360,979 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	18,359,664 - 18,360,979 (-)	NCBI	ChiLan1.0	ChiLan1.0

GP1BB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	29,351,021 - 29,352,346 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	31,898,748 - 31,900,073 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	2,485,350 - 2,486,688 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

Gp1bb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	139,124,933 - 139,126,427 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	3,627,999 - 3,628,859 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	3,627,649 - 3,629,129 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GP1BB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	51,260,963 - 51,262,114 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	51,261,097 - 51,261,903 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	54,900,394 - 54,901,102 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GP1BB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	6,020,618 - 6,021,646 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666085	904,704 - 906,255 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gp1bb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	352,165 - 354,170 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	352,129 - 354,173 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GP1BB
23 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium					1
Low					3
Below cutoff	4	5	13	2	2	2	6	2	12	5	6	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005636588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000049323 ⟹ ENSCAFP00000036500

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	26	29,528,366 - 29,568,522 (-)	Ensembl

RefSeq Acc Id:

XM_005636588 ⟹ XP_005636645

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	26	29,567,437 - 29,568,627 (-)	NCBI
Dog10K_Boxer_Tasha	26	29,524,678 - 29,525,676 (-)	NCBI

Sequence:

show sequence

CTTGGCGGGCCCTGGGGCCTGGCAGGGGCGGGGCGGCCTTATCGCCTGGCTCTCCAGCCCAAGC
TTCGCGCTCCAGAGCCAGCCGGGTCACCATCCTCTCTCGCCATGGGCTCCGGGCCGCGCGGGGC
GCTGAGCCTGCTGCTCCTGCCGCTCCTGCTCCTGGCGCCGCCGGGCCGCCGGGCCGCGGGCTGC
CCCGCGCCGTGTGACTGCGCGGGGACGCGCGTGGATTGCGGGCGCCGCGGGCTGACGCGGGCCA
CGCTGCCCGCCGCCTTCCCGCCGGACACGACCGAGCTGGTGCTGACGGGCAACAATCTGACGGG
GCTGCCGCGCGGACTGCTGGACACGCTGCCCGCACTGCGCGCCGCTCACCTGGGCGCCAACCCC
TGGCGCTGCGACTGCCACCTGGTGCCGCTGCGCGCCTGGCTGGCCGGCCGGCCGGAGCGCGCGC
CCTACCGCGACCTGCGCTGCGCCGCGCCCCCCGCGCTGCGCGGCCGCCTGCTGCCCTACCTGGC
GGAGGAGGAGCTGCGCGCCGCCTGTCCGCCCGGCGCGCTCTGCTGGGGGGCGCTGGGGGCGCAG
CTGCTGCTGCTCGGCCTCGGGCTGCTGCACGCGCTGCTGCTGCTGCTGCTGCTGTGCCGGCTGC
GCAGACTCCGCGCCCGCGCCGCGCACCCCTCGCCGCTGAGCGCGCCGCTCGTGGGGCCCGGGAG
GAGTCCCGAGGAGCGCTGAGCCCCGCGGGCGCCGCCCCCCGACGGGACCCTGGGCCGAGGGGCC
CCCGGGCTCGACGTCCCTGCCCACGCCGCCCCCGCGGGCCCCCCACTAGCACTAGCGGGGCGAG
CCCGTGCCCGGGACGCGCAGGCGGGGCCAGGGGGGACCGCAGCCCGGCCCCTGCGAGGTCCCCC
GCGCCAAACTCCGGTGCACAATAAACCCTTCTCCCCGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005636645	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000036500.3
	ENSCAFP00030032935.1
	ENSCAFP00030032976.1
	ENSCAFP00040037185.1

RefSeq Acc Id:

XP_005636645 ⟸ XM_005636588

- UniProtKB:

A0A8C0TJH3 (UniProtKB/TrEMBL), A0A8P0NNK3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSGPRGALSLLLLPLLLLAPPGRRAAGCPAPCDCAGTRVDCGRRGLTRATLPAAFPPDTTELV
LTGNNLTGLPRGLLDTLPALRAAHLGANPWRCDCHLVPLRAWLAGRPERAPYRDLRCAAPPALR
GRLLPYLAEEELRAACPPGALCWGALGAQLLLLGLGLLHALLLLLLLCRLRRLRARAAHPSPLS
APLVGPGRSPEER

hide sequence

RefSeq Acc Id:

ENSCAFP00000036500 ⟸ ENSCAFT00000049323

Protein Domains

LRRCT LRRNT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000029230	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030020579	UniProtKB/TrEMBL
	ENSCAFG00040022924	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000049323.3	UniProtKB/TrEMBL
	ENSCAFT00030037746.1	UniProtKB/TrEMBL
	ENSCAFT00030037795.1	UniProtKB/TrEMBL
	ENSCAFT00040042625.1	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	LRRNT	UniProtKB/TrEMBL
KEGG Report	cfa:102155348	UniProtKB/TrEMBL
NCBI Gene	GP1BB	ENTREZGENE
PANTHER	GLYCOPROTEIN IB BETA	UniProtKB/TrEMBL
	PLATELET GLYCOPROTEIN IB BETA CHAIN	UniProtKB/TrEMBL
Pfam	LRRCT	UniProtKB/TrEMBL
	LRRNT	UniProtKB/TrEMBL
SMART	LRRCT	UniProtKB/TrEMBL
	LRRNT	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
UniProt	A0A8C0NYI4_CANLF	UniProtKB/TrEMBL
	A0A8C0TJH3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NNK3	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:41355	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	GP1BB	glycoprotein Ib platelet subunit beta		glycoprotein Ib platelet beta subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations