MRI1 (methylthioribose-1-phosphate isomerase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MRI1 (methylthioribose-1-phosphate isomerase 1) Canis lupus familiaris
Analyze
Symbol: MRI1
Name: methylthioribose-1-phosphate isomerase 1
RGD ID: 12337881
Description: ENCODES a protein that exhibits identical protein binding (inferred); isomerase activity (inferred); S-methyl-5-thioribose-1-phosphate isomerase activity (inferred); INVOLVED IN L-methionine salvage from methylthioadenosine (inferred); methionine biosynthetic process (inferred); ASSOCIATED WITH neurodegenerative disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); fibrillar center (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methylthioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,648,987 - 48,658,231 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,653,152 - 48,658,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,522,944 - 48,532,179 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,167,118 - 49,176,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,171,006 - 49,176,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,377,542 - 48,386,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,804,655 - 48,813,684 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,047,748 - 49,056,780 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
fibrillar center  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MRI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,648,987 - 48,658,231 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,653,152 - 48,658,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,522,944 - 48,532,179 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,167,118 - 49,176,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,171,006 - 49,176,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,377,542 - 48,386,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,804,655 - 48,813,684 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,047,748 - 49,056,780 (-)NCBIUU_Cfam_GSD_1.0
MRI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,764,522 - 13,774,282 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,764,522 - 13,774,282 (+)EnsemblGRCh38hg38GRCh38
GRCh371913,875,336 - 13,885,096 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,736,337 - 13,746,096 (+)NCBINCBI36Build 36hg18NCBI36
Celera1913,769,122 - 13,778,884 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1913,447,016 - 13,456,733 (+)NCBIHuRef
CHM1_11913,875,880 - 13,885,599 (+)NCBICHM1_1
T2T-CHM13v2.01913,890,747 - 13,900,482 (+)NCBIT2T-CHM13v2.0
Mri1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,977,205 - 84,983,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,976,535 - 84,983,955 (-)EnsemblGRCm39 Ensembl
GRCm38884,250,576 - 84,257,324 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,249,906 - 84,257,326 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,774,475 - 86,781,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,140,011 - 87,147,431 (-)NCBIMGSCv36mm8
Celera888,552,772 - 88,559,465 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.74NCBI
Mri1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,812,114 - 40,819,846 (+)NCBIGRCr8
mRatBN7.21923,907,327 - 23,913,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,907,335 - 23,913,320 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,728,393 - 30,734,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,382,802 - 31,389,195 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,605,548 - 33,611,943 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,360,299 - 25,366,283 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,360,164 - 25,366,806 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,336,487 - 36,342,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,591,115 - 25,597,099 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,595,940 - 25,601,925 (+)NCBI
Celera1923,456,210 - 23,462,198 (+)NCBICelera
Cytogenetic Map19q11NCBI
Mri1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,585,756 - 32,589,261 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,585,714 - 32,589,343 (+)NCBIChiLan1.0ChiLan1.0
MRI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22018,694,501 - 18,703,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11917,695,420 - 17,704,140 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,327,569 - 13,336,286 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,060,777 - 14,067,521 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,060,859 - 14,067,222 (+)Ensemblpanpan1.1panPan2
Mri1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,822,219 - 207,827,836 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,527,472 - 2,532,416 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,526,274 - 2,532,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,348,006 - 65,355,118 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,348,609 - 65,354,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,675,853 - 65,682,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,424,835 - 12,431,911 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl612,425,052 - 12,431,844 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660747,254,693 - 7,263,317 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mri1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,106,059 - 1,109,931 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249011,105,763 - 1,110,281 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MRI1
140 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026335   ⟹   ENSCAFP00000024457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2048,653,152 - 48,658,160 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047896   ⟹   ENSCAFP00845037573
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2049,171,006 - 49,176,338 (-)Ensembl
RefSeq Acc Id: XM_022406981   ⟹   XP_022262689
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12048,648,987 - 48,658,231 (-)NCBI
Dog10K_Boxer_Tasha2048,522,944 - 48,532,179 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038428416   ⟹   XP_038284344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02049,167,118 - 49,176,373 (-)NCBI
RefSeq Acc Id: XM_038504060   ⟹   XP_038359988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12048,377,542 - 48,386,796 (-)NCBI
RefSeq Acc Id: XM_038567085   ⟹   XP_038423013
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02049,047,748 - 49,056,780 (-)NCBI
RefSeq Acc Id: XM_038631229   ⟹   XP_038487157
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02048,804,655 - 48,813,684 (-)NCBI
RefSeq Acc Id: XP_022262689   ⟸   XM_022406981
- UniProtKB: A0A8C0JYK6 (UniProtKB/TrEMBL),   A0A8I3PVF4 (UniProtKB/TrEMBL),   A0A8P0NHY9 (UniProtKB/TrEMBL),   A0A8C0MVW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000024457   ⟸   ENSCAFT00000026335
RefSeq Acc Id: XP_038359988   ⟸   XM_038504060
RefSeq Acc Id: XP_038487157   ⟸   XM_038631229
RefSeq Acc Id: XP_038284344   ⟸   XM_038428416
- UniProtKB: A0A8C0JYK6 (UniProtKB/TrEMBL),   A0A8I3PVF4 (UniProtKB/TrEMBL),   A0A8P0NHY9 (UniProtKB/TrEMBL),   A0A8C0MVW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423013   ⟸   XM_038567085
- UniProtKB: A0A8C0MVW3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845037573   ⟸   ENSCAFT00845047896

Promoters
RGD ID:13686996
Promoter ID:EPDNEW_C5064
Type:initiation region
Name:MRI1_1
Description:methylthioribose-1-phosphate isomerase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12048,658,217 - 48,658,277EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016615 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010979 UniProtKB/TrEMBL
  ENSCAFG00040020733 UniProtKB/TrEMBL
  ENSCAFG00845027181 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026335.5 UniProtKB/TrEMBL
  ENSCAFT00030020313.1 UniProtKB/TrEMBL
  ENSCAFT00040038375.1 UniProtKB/TrEMBL
  ENSCAFT00845047896 ENTREZGENE
  ENSCAFT00845047896.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.420 UniProtKB/TrEMBL
InterPro IF-2B-related UniProtKB/TrEMBL
  IF-M1Pi UniProtKB/TrEMBL
  IF_2B-like_C UniProtKB/TrEMBL
  Initiation_fac_2B_a/b/d UniProtKB/TrEMBL
  M1Pi_N UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
NCBI Gene MRI1 ENTREZGENE
PANTHER METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE UniProtKB/TrEMBL
  METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE UniProtKB/TrEMBL
Pfam IF-2B UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/TrEMBL
UniProt A0A8C0JYK6 ENTREZGENE
  A0A8C0MVW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PVF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NHY9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43365 ENTREZGENE