TRAM1L1 (translocation associated membrane protein 1 like 1) - Rat Genome Database

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Gene: TRAM1L1 (translocation associated membrane protein 1 like 1) Canis lupus familiaris
Analyze
Symbol: TRAM1L1
Name: translocation associated membrane protein 1 like 1
RGD ID: 12336774
Description: INVOLVED IN protein insertion into ER membrane (inferred); protein transport (inferred); SRP-dependent cotranslational protein targeting to membrane, translocation (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: translocating chain-associated membrane protein 1-like 1; translocation associated membrane protein 1-like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13236,487,648 - 36,489,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3236,488,434 - 36,489,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha325,525,547 - 5,527,509 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03236,711,007 - 36,712,963 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3236,711,788 - 36,713,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13236,739,734 - 36,741,689 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03236,461,578 - 36,463,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0323,339,889 - 3,341,846 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TRAM1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13236,487,648 - 36,489,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3236,488,434 - 36,489,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha325,525,547 - 5,527,509 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03236,711,007 - 36,712,963 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3236,711,788 - 36,713,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13236,739,734 - 36,741,689 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03236,461,578 - 36,463,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0323,339,889 - 3,341,846 (+)NCBIUU_Cfam_GSD_1.0
TRAM1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384117,083,554 - 117,085,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4117,083,554 - 117,085,576 (-)EnsemblGRCh38hg38GRCh38
GRCh374118,004,710 - 118,006,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364118,224,158 - 118,226,184 (-)NCBINCBI36Build 36hg18NCBI36
Build 344118,362,312 - 118,364,335NCBI
Celera4115,296,907 - 115,298,933 (-)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4113,738,786 - 113,740,812 (-)NCBIHuRef
CHM1_14117,981,165 - 117,983,191 (-)NCBICHM1_1
T2T-CHM13v2.04120,385,256 - 120,387,278 (-)NCBIT2T-CHM13v2.0
Tram1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393124,114,686 - 124,116,909 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3124,114,504 - 124,118,392 (+)EnsemblGRCm39 Ensembl
GRCm383124,321,037 - 124,323,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3124,320,855 - 124,324,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv373124,023,955 - 124,026,178 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363124,313,131 - 124,315,282 (+)NCBIMGSCv36mm8
Celera3130,728,926 - 130,731,149 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map354.68NCBI
Tram1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82215,195,665 - 215,197,846 (+)NCBIGRCr8
mRatBN7.22212,511,130 - 212,513,311 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2220,195,443 - 220,197,626 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02218,095,335 - 218,097,518 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02212,949,548 - 212,951,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02228,544,418 - 228,546,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2228,544,418 - 228,546,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02247,895,258 - 247,897,439 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42221,093,369 - 221,095,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12221,079,931 - 221,081,152 (+)NCBI
Celera2204,909,606 - 204,911,787 (+)NCBICelera
Cytogenetic Map2q42NCBI
Tram1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542822,645,785 - 22,646,906 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542822,645,718 - 22,647,763 (+)NCBIChiLan1.0ChiLan1.0
TRAM1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23115,108,751 - 115,110,619 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14115,400,546 - 115,402,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04109,519,973 - 109,521,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14120,078,448 - 120,080,493 (-)NCBIpanpan1.1PanPan1.1panPan2
Tram1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053014,276,741 - 4,279,073 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493694284,816 - 85,934 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493694284,596 - 86,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAM1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8106,283,243 - 106,289,490 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18106,283,197 - 106,291,187 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28114,287,244 - 114,290,786 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRAM1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1764,875,697 - 64,878,020 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603743,701,884 - 43,705,319 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tram1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248674,075,090 - 4,076,199 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248674,074,379 - 4,076,346 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TRAM1L1
34 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 16 1 6 12 8 10 6
Low 5 1 6 6 5 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000045111   ⟹   ENSCAFP00000035953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3236,488,434 - 36,489,546 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845052139   ⟹   ENSCAFP00845040895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3236,711,788 - 36,713,131 (-)Ensembl
RefSeq Acc Id: XM_005639314   ⟹   XP_005639371
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13236,487,648 - 36,489,596 (-)NCBI
Dog10K_Boxer_Tasha325,525,547 - 5,527,509 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038444504   ⟹   XP_038300432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03236,711,007 - 36,712,963 (-)NCBI
RefSeq Acc Id: XM_038518900   ⟹   XP_038374828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13236,739,734 - 36,741,689 (-)NCBI
RefSeq Acc Id: XM_038581777   ⟹   XP_038437705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0323,339,889 - 3,341,846 (+)NCBI
RefSeq Acc Id: XM_038646839   ⟹   XP_038502767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03236,461,578 - 36,463,532 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005639371   ⟸   XM_005639314
- UniProtKB: A0A8P0NNB0 (UniProtKB/TrEMBL),   A0A8I3S761 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035953   ⟸   ENSCAFT00000045111
RefSeq Acc Id: XP_038374828   ⟸   XM_038518900
RefSeq Acc Id: XP_038502767   ⟸   XM_038646839
RefSeq Acc Id: XP_038300432   ⟸   XM_038444504
- UniProtKB: A0A8I3S761 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437705   ⟸   XM_038581777
- UniProtKB: A0A8I3S761 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845040895   ⟸   ENSCAFT00845052139
Protein Domains
TLC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030514 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845029459 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045111.2 UniProtKB/TrEMBL
  ENSCAFT00845052139 ENTREZGENE
  ENSCAFT00845052139.1 UniProtKB/TrEMBL
InterPro TLC-dom UniProtKB/TrEMBL
  Translocation_assoc_membrane UniProtKB/TrEMBL
KEGG Report cfa:487917 UniProtKB/TrEMBL
NCBI Gene TRAM1L1 ENTREZGENE
PANTHER PTHR12371 UniProtKB/TrEMBL
  TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 1-LIKE 1 UniProtKB/TrEMBL
Pfam TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PIRSF Translocation_assoc_membrane UniProtKB/TrEMBL
PROSITE TLC UniProtKB/TrEMBL
SMART TLC UniProtKB/TrEMBL
UniProt A0A8I3S761 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NNB0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49114 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 TRAM1L1  translocation associated membrane protein 1 like 1    translocation associated membrane protein 1-like 1  Symbol and/or name change 5135510 APPROVED