ASTL (astacin like metalloendopeptidase) - Rat Genome Database

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Gene: ASTL (astacin like metalloendopeptidase) Canis lupus familiaris
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Symbol: ASTL
Name: astacin like metalloendopeptidase
RGD ID: 12336288
Description: ENCODES a protein that exhibits aspartic-type peptidase activity (inferred); glutamic-type peptidase activity (inferred); metal ion binding (inferred); INVOLVED IN cell adhesion (inferred); fertilization (inferred); negative regulation of binding of sperm to zona pellucida (inferred); ASSOCIATED WITH intellectual disability (ortholog); Oocyte/Zygote/Embryo Maturation Arrest 11 (ortholog); pheochromocytoma (ortholog); FOUND IN cortical granule (inferred); cytoplasm (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: astacin-like metallo-endopeptidase (M12 family); astacin-like metalloendopeptidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,594,701 - 34,608,708 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,594,026 - 34,607,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,363,562 - 34,378,272 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,365,149 - 35,379,752 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,365,007 - 35,379,047 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,494,438 - 34,509,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,562,766 - 34,577,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,769,924 - 34,784,663 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,594,701 - 34,608,708 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,594,026 - 34,607,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,363,562 - 34,378,272 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,365,149 - 35,379,752 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,365,007 - 35,379,047 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,494,438 - 34,509,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,562,766 - 34,577,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,769,924 - 34,784,663 (+)NCBIUU_Cfam_GSD_1.0
ASTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,122,818 - 96,138,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,122,818 - 96,138,502 (-)EnsemblGRCh38hg38GRCh38
GRCh37296,788,557 - 96,804,241 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,153,316 - 96,167,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 34296,211,462 - 96,226,049NCBI
Celera291,230,396 - 91,244,982 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,750,866 - 90,765,452 (-)NCBIHuRef
CHM1_1296,793,916 - 96,808,503 (-)NCBICHM1_1
T2T-CHM13v2.0296,629,422 - 96,645,168 (-)NCBIT2T-CHM13v2.0
Astl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,180,559 - 127,199,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,180,559 - 127,199,571 (+)EnsemblGRCm39 Ensembl
GRCm382127,338,639 - 127,357,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,338,639 - 127,357,651 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,164,375 - 127,183,387 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,030,080 - 127,049,092 (+)NCBIMGSCv36mm8
Celera2128,584,628 - 128,599,928 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.93NCBI
Astl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,016,444 - 135,032,177 (+)NCBIGRCr8
mRatBN7.23114,563,135 - 114,580,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,452,397 - 118,468,141 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,047,958 - 127,063,702 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,708,329 - 124,724,073 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,783,717 - 119,799,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,310,094 - 126,325,827 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,845,320 - 114,861,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3113,402,096 - 113,417,834 (+)NCBICelera
Cytogenetic Map3q36NCBI
Astl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,719,254 - 3,732,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,719,254 - 3,732,598 (-)NCBIChiLan1.0ChiLan1.0
ASTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,169,814 - 32,185,721 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,172,596 - 32,188,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,176,662 - 103,192,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,048,871 - 97,063,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A97,049,184 - 97,063,747 (-)Ensemblpanpan1.1panPan2
Astl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,005,750 - 83,015,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744259,188 - 268,928 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744259,188 - 268,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,059,040 - 47,070,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1347,058,104 - 47,071,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,198,467 - 49,211,812 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114568,071 - 577,182 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041167,978,725 - 167,994,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Astl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247492,241,511 - 2,254,640 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ASTL
283 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00000070566   ⟹   ENSCAFP00000045771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1734,594,026 - 34,607,961 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845011117   ⟹   ENSCAFP00845008674
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1735,365,007 - 35,379,047 (+)Ensembl
RefSeq Acc Id: XM_022404688   ⟹   XP_022260396
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11734,594,701 - 34,608,708 (+)NCBI
Dog10K_Boxer_Tasha1734,363,562 - 34,378,272 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038499903   ⟹   XP_038355831
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11734,494,438 - 34,509,160 (+)NCBI
RefSeq Acc Id: XM_038560593   ⟹   XP_038416521
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01734,769,924 - 34,784,663 (+)NCBI
RefSeq Acc Id: XM_038624621   ⟹   XP_038480549
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01734,562,766 - 34,577,482 (+)NCBI
RefSeq Acc Id: XM_038690533   ⟹   XP_038546461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01735,365,149 - 35,379,752 (+)NCBI
RefSeq Acc Id: XP_022260396   ⟸   XM_022404688
- UniProtKB: A0A8C0L2C8 (UniProtKB/TrEMBL),   A0A8I3N291 (UniProtKB/TrEMBL),   A0A8P0SYT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000045771   ⟸   ENSCAFT00000070566
RefSeq Acc Id: XP_038355831   ⟸   XM_038499903
RefSeq Acc Id: XP_038480549   ⟸   XM_038624621
RefSeq Acc Id: XP_038546461   ⟸   XM_038690533
- UniProtKB: A0A8C0L2C8 (UniProtKB/TrEMBL),   A0A8I3N291 (UniProtKB/TrEMBL),   A0A8P0SYT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416521   ⟸   XM_038560593
- UniProtKB: A0A8C0L2C8 (UniProtKB/TrEMBL),   A0A8I3N291 (UniProtKB/TrEMBL),   A0A8P0SYT9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845008674   ⟸   ENSCAFT00845011117
Protein Domains
Peptidase M12A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000046427 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845006271 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000070566.2 UniProtKB/TrEMBL
  ENSCAFT00845011117 ENTREZGENE
  ENSCAFT00845011117.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
NCBI Gene ASTL ENTREZGENE
PANTHER ASTACIN-LIKE METALLOENDOPEPTIDASE UniProtKB/TrEMBL
  DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
SMART ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8C0L2C8 ENTREZGENE
  A0A8I3N291 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SYT9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111351 ENTREZGENE