COMP (cartilage oligomeric matrix protein) - Rat Genome Database

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Gene: COMP (cartilage oligomeric matrix protein) Canis lupus familiaris
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Symbol: COMP
Name: cartilage oligomeric matrix protein
RGD ID: 12333559
Description: ENCODES a protein that exhibits extracellular matrix structural constituent (ortholog); fibronectin binding (ortholog); vitamin D binding (ortholog); INVOLVED IN apoptotic process (ortholog); artery morphogenesis (ortholog); blood coagulation (ortholog); ASSOCIATED WITH carpal tunnel syndrome 2 (ortholog); connective tissue disease (ortholog); genetic disease (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,306,813 - 44,314,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,306,859 - 44,314,625 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,221,457 - 44,229,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02044,793,007 - 44,800,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,793,063 - 44,800,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,030,270 - 44,038,042 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,440,677 - 44,448,355 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02044,715,955 - 44,723,648 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:17669022   PMID:20042950   PMID:22301074   PMID:22440362  


Genomics

Comparative Map Data
COMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,306,813 - 44,314,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,306,859 - 44,314,625 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,221,457 - 44,229,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02044,793,007 - 44,800,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,793,063 - 44,800,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,030,270 - 44,038,042 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,440,677 - 44,448,355 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02044,715,955 - 44,723,648 (+)NCBIUU_Cfam_GSD_1.0
COMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,782,773 - 18,791,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,782,773 - 18,791,305 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,893,583 - 18,902,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,754,583 - 18,763,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,754,583 - 18,763,114NCBI
Celera1918,798,378 - 18,806,909 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,458,025 - 18,466,569 (-)NCBIHuRef
CHM1_11918,893,587 - 18,902,107 (-)NCBICHM1_1
T2T-CHM13v2.01918,918,369 - 18,926,902 (-)NCBIT2T-CHM13v2.0
Comp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,826,186 - 70,834,721 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl870,826,208 - 70,834,716 (+)EnsemblGRCm39 Ensembl
GRCm38870,373,548 - 70,382,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,373,558 - 70,382,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,897,447 - 72,905,965 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,302,547 - 73,311,055 (+)NCBIMGSCv36mm8
Celera872,929,973 - 72,938,489 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Comp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,081,172 - 19,089,548 (-)NCBIGRCr8
mRatBN7.21619,047,206 - 19,055,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,047,207 - 19,055,845 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1619,086,958 - 19,095,161 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,219,417 - 20,227,820 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01619,139,921 - 19,148,124 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,798,437 - 20,807,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,798,437 - 20,807,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,647,382 - 20,657,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1619,237,609 - 19,245,998 (-)NCBICelera
Cytogenetic Map16p14NCBI
COMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,643,332 - 23,652,510 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,651,519 - 22,661,150 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01918,222,270 - 18,230,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11919,229,420 - 19,238,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,229,562 - 19,238,008 (-)Ensemblpanpan1.1panPan2
Comp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,995,236 - 203,002,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,544,389 - 2,551,164 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,544,389 - 2,551,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,061,426 - 59,069,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,061,409 - 59,068,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,815,756 - 58,823,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,246,617 - 17,255,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl617,246,762 - 17,255,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,070,833 - 2,079,420 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Comp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,871,002 - 1,877,369 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,870,975 - 1,877,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COMP
46 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023228   ⟹   ENSCAFP00000021570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2044,306,859 - 44,314,507 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000077038   ⟹   ENSCAFP00000049903
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2044,306,859 - 44,314,507 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000082068   ⟹   ENSCAFP00000055935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2044,306,859 - 44,314,625 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845035299   ⟹   ENSCAFP00845027630
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2044,793,063 - 44,800,711 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845035455   ⟹   ENSCAFP00845027747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2044,793,063 - 44,800,711 (+)Ensembl
RefSeq Acc Id: XM_038428109   ⟹   XP_038284037
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02044,793,007 - 44,800,779 (+)NCBI
RefSeq Acc Id: XM_038503767   ⟹   XP_038359695
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12044,030,270 - 44,038,042 (+)NCBI
RefSeq Acc Id: XM_038566792   ⟹   XP_038422720
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02044,715,955 - 44,723,648 (+)NCBI
RefSeq Acc Id: XM_038630933   ⟹   XP_038486861
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02044,440,677 - 44,448,355 (+)NCBI
RefSeq Acc Id: XM_533869   ⟹   XP_533869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12044,306,813 - 44,314,575 (+)NCBI
Dog10K_Boxer_Tasha2044,221,457 - 44,229,145 (+)NCBI
Sequence:
RefSeq Acc Id: XP_533869   ⟸   XM_533869
- UniProtKB: A0A8C0TLZ8 (UniProtKB/TrEMBL),   A0A8I3P787 (UniProtKB/TrEMBL),   A0A8C0NSG9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000049903   ⟸   ENSCAFT00000077038
Ensembl Acc Id: ENSCAFP00000021570   ⟸   ENSCAFT00000023228
Ensembl Acc Id: ENSCAFP00000055935   ⟸   ENSCAFT00000082068
RefSeq Acc Id: XP_038359695   ⟸   XM_038503767
RefSeq Acc Id: XP_038486861   ⟸   XM_038630933
RefSeq Acc Id: XP_038284037   ⟸   XM_038428109
- UniProtKB: A0A8C0TLZ8 (UniProtKB/TrEMBL),   A0A8I3P787 (UniProtKB/TrEMBL),   A0A8C0NSG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038422720   ⟸   XM_038566792
- UniProtKB: A0A8C0NSG9 (UniProtKB/TrEMBL),   A0A8C0TLZ8 (UniProtKB/TrEMBL),   A0A8I3P787 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845027747   ⟸   ENSCAFT00845035455
Ensembl Acc Id: ENSCAFP00845027630   ⟸   ENSCAFT00845035299
Protein Domains
EGF-like   TSP C-terminal

Promoters
RGD ID:13686933
Promoter ID:EPDNEW_C5001
Type:single initiation site
Name:COMP_1
Description:cartilage oligomeric matrix protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12044,306,772 - 44,306,832EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014616 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015319 UniProtKB/TrEMBL
  ENSCAFG00040022608 UniProtKB/TrEMBL
  ENSCAFG00845020025 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023228.5 UniProtKB/TrEMBL
  ENSCAFT00000077038.2 UniProtKB/TrEMBL
  ENSCAFT00030028255.1 UniProtKB/TrEMBL
  ENSCAFT00030028390.1 UniProtKB/TrEMBL
  ENSCAFT00030028585.1 UniProtKB/TrEMBL
  ENSCAFT00040041980.1 UniProtKB/TrEMBL
  ENSCAFT00040042056.1 UniProtKB/TrEMBL
  ENSCAFT00040042132.1 UniProtKB/TrEMBL
  ENSCAFT00845035299 ENTREZGENE
  ENSCAFT00845035299.1 UniProtKB/TrEMBL
  ENSCAFT00845035455.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  4.10.1080.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Thbs/COMP_coiled-coil UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/TrEMBL
  TSP-5_cc UniProtKB/TrEMBL
  TSP/COMP_coiled-coil_sf UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/TrEMBL
KEGG Report cfa:476665 UniProtKB/TrEMBL
NCBI Gene COMP ENTREZGENE
PANTHER PTHR10199:SF88 UniProtKB/TrEMBL
  THROMBOSPONDIN UniProtKB/TrEMBL
Pfam COMP UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP_3 UniProtKB/TrEMBL
  TSP_C UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP3 UniProtKB/TrEMBL
  TSP_CTER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP Assembly domain of cartilage oligomeric matrix protein UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  SSF103647 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A8C0NDA9_CANLF UniProtKB/TrEMBL
  A0A8C0NHI9_CANLF UniProtKB/TrEMBL
  A0A8C0NSG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TII3_CANLF UniProtKB/TrEMBL
  A0A8C0TKD4_CANLF UniProtKB/TrEMBL
  A0A8C0TLZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P787 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S498_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:39500 ENTREZGENE