KLRB1 (killer cell lectin like receptor B1) - Rat Genome Database

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Gene: KLRB1 (killer cell lectin like receptor B1) Canis lupus familiaris
Analyze
Symbol: KLRB1
Name: killer cell lectin like receptor B1
RGD ID: 12332082
Description: ENCODES a protein that exhibits signaling receptor activity (inferred); INVOLVED IN regulation of natural killer cell mediated cytotoxicity (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); melanoma (ortholog); FOUND IN cell surface (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,355,917 - 36,376,172 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2736,355,986 - 36,376,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,241,214 - 10,263,747 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,707,314 - 36,729,874 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,707,374 - 36,729,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,606,421 - 36,612,015 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,617,769 - 36,640,369 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,773,520 - 9,788,771 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)
genetic disease  (ISO)
melanoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
KLRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,355,917 - 36,376,172 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2736,355,986 - 36,376,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,241,214 - 10,263,747 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,707,314 - 36,729,874 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,707,374 - 36,729,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,606,421 - 36,612,015 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,617,769 - 36,640,369 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,773,520 - 9,788,771 (-)NCBIUU_Cfam_GSD_1.0
KLRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,594,551 - 9,607,916 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,594,551 - 9,607,916 (-)EnsemblGRCh38hg38GRCh38
GRCh37129,747,147 - 9,760,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,639,137 - 9,651,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 34129,639,137 - 9,651,764NCBI
Celera1214,909,231 - 14,921,909 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,490,635 - 9,503,276 (-)NCBIHuRef
CHM1_1129,716,848 - 9,729,496 (-)NCBICHM1_1
T2T-CHM13v2.0129,480,754 - 9,494,170 (-)NCBIT2T-CHM13v2.0
Klrb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,586,190 - 128,599,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,586,190 - 128,600,496 (-)EnsemblGRCm39 Ensembl
GRCm386128,609,227 - 128,622,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,609,227 - 128,623,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv376128,559,245 - 128,572,952 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366128,574,846 - 128,588,444 (-)NCBIMGSCv36mm8
Celera6130,286,421 - 130,300,140 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.06NCBI
Klrb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,576,672 - 163,590,201 (-)NCBIGRCr8
mRatBN7.24161,890,577 - 161,904,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,890,577 - 161,961,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4168,125,617 - 168,139,099 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04163,908,558 - 163,922,040 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,542,599 - 162,556,083 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04161,950,270 - 161,966,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,949,817 - 162,025,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,150,602 - 227,167,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,637,478 - 165,654,188 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,591,734 - 150,605,311 (-)NCBICelera
Cytogenetic Map4q42NCBI
KLRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,087,022 - 15,098,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,083,781 - 15,095,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0129,644,078 - 9,656,303 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,892,986 - 9,905,255 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,892,986 - 9,905,255 (-)Ensemblpanpan1.1panPan2
LOC101962075
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,065,021 - 98,076,420 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936870702,606 - 706,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,244,713 - 62,257,694 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,244,787 - 62,257,691 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,081,320 - 65,094,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,471,914 - 9,516,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,481,275 - 9,494,310 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660891,550,332 - 1,563,208 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in KLRB1
327 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 7 6 6 6 2 1 5 1
Below cutoff 5 4 15 4 3 7 4 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021572   ⟹   ENSCAFP00000020030
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2736,355,986 - 36,376,501 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049656   ⟹   ENSCAFP00845038949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2736,707,374 - 36,729,870 (+)Ensembl
RefSeq Acc Id: XM_005637170   ⟹   XP_005637227
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12736,355,917 - 36,376,172 (+)NCBI
Dog10K_Boxer_Tasha2710,241,214 - 10,263,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038437908   ⟹   XP_038293836
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02736,707,314 - 36,729,874 (+)NCBI
RefSeq Acc Id: XM_038514317   ⟹   XP_038370245
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12736,606,421 - 36,612,015 (+)NCBI
RefSeq Acc Id: XM_038576122   ⟹   XP_038432050
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0279,773,520 - 9,788,771 (-)NCBI
RefSeq Acc Id: XM_038640363   ⟹   XP_038496291
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02736,617,769 - 36,640,369 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005637227   ⟸   XM_005637170
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NY39 (UniProtKB/TrEMBL),   A0A8I3SBB8 (UniProtKB/TrEMBL),   A0A8C0QWA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000020030   ⟸   ENSCAFT00000021572
RefSeq Acc Id: XP_038370245   ⟸   XM_038514317
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038496291   ⟸   XM_038640363
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293836   ⟸   XM_038437908
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NY39 (UniProtKB/TrEMBL),   A0A8I3SBB8 (UniProtKB/TrEMBL),   A0A8C0QWA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432050   ⟸   XM_038576122
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NY39 (UniProtKB/TrEMBL),   A0A8C0QWA3 (UniProtKB/TrEMBL),   A0A8I3SBB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038949   ⟸   ENSCAFT00845049656
Protein Domains
C-type lectin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013612 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021259 UniProtKB/TrEMBL
  ENSCAFG00845028140 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021572.5 UniProtKB/TrEMBL
  ENSCAFT00030039051.1 UniProtKB/TrEMBL
  ENSCAFT00845049656 ENTREZGENE
  ENSCAFT00845049656.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/TrEMBL
KEGG Report cfa:100684789 UniProtKB/TrEMBL
NCBI Gene KLRB1 ENTREZGENE
PANTHER KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/TrEMBL
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/TrEMBL
UniProt A0A8C0NY39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QWA3 ENTREZGENE
  A0A8I3SBB8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42485 ENTREZGENE