MESP1 (mesoderm posterior bHLH transcription factor 1) - Rat Genome Database

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Gene: MESP1 (mesoderm posterior bHLH transcription factor 1) Canis lupus familiaris
Analyze
Symbol: MESP1
Name: mesoderm posterior bHLH transcription factor 1
RGD ID: 12328102
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cardioblast migration (ortholog); gene expression (ortholog); heart morphogenesis (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); congenital heart disease (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mesoderm posterior 1 homolog; mesoderm posterior protein 1; MESP2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,738,333 - 52,739,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,738,366 - 52,739,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,372,284 - 55,373,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,155,122 - 53,156,692 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,155,145 - 53,156,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,676,925 - 52,678,493 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,886,866 - 52,888,431 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,227,220 - 53,228,790 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac atrium formation  (IEA)
cardiac cell fate determination  (IEA)
cardiac muscle cell differentiation  (IEA)
cardiac vascular smooth muscle cell differentiation  (IEA)
cardiac ventricle formation  (IEA)
cardioblast anterior-lateral migration  (IEA)
cardioblast migration  (IEA,ISO)
cardioblast migration to the midline involved in heart field formation  (IEA)
embryonic heart tube morphogenesis  (IEA)
endothelial cell differentiation  (IEA)
gastrulation  (IEA)
gene expression  (IEA,ISO)
growth involved in heart morphogenesis  (IEA)
heart induction  (IEA)
heart looping  (IEA)
heart morphogenesis  (IEA,ISO)
lateral mesoderm development  (IEA)
mesoderm formation  (IEA)
mesodermal cell migration  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of endodermal cell fate specification  (IEA)
negative regulation of mesodermal cell fate specification  (IEA)
neurogenesis  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of hepatocyte differentiation  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of striated muscle cell differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
secondary heart field specification  (IEA)
signal transduction involved in regulation of gene expression  (IEA,ISO)
sinoatrial node cell differentiation  (IEA)
sinus venosus morphogenesis  (IEA)
somite rostral/caudal axis specification  (IEA)

Cellular Component
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MESP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,738,333 - 52,739,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,738,366 - 52,739,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,372,284 - 55,373,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,155,122 - 53,156,692 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,155,145 - 53,156,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,676,925 - 52,678,493 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,886,866 - 52,888,431 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,227,220 - 53,228,790 (-)NCBIUU_Cfam_GSD_1.0
MESP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,732,446 - 89,751,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,749,875 - 89,751,249 (-)EnsemblGRCh38hg38GRCh38
GRCh371590,293,106 - 90,294,480 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,094,110 - 88,095,552 (-)NCBINCBI36Build 36hg18NCBI36
Celera1566,695,858 - 66,697,300 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,406,054 - 66,407,496 (-)NCBIHuRef
CHM1_11590,133,926 - 90,135,368 (-)NCBICHM1_1
T2T-CHM13v2.01587,488,329 - 87,507,126 (-)NCBIT2T-CHM13v2.0
Mesp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,441,989 - 79,443,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,441,989 - 79,443,536 (-)EnsemblGRCm39 Ensembl
GRCm38779,792,241 - 79,793,590 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,792,241 - 79,793,788 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,937,127 - 86,938,476 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,665,760 - 79,667,119 (-)NCBIMGSCv36mm8
Celera777,191,445 - 77,192,794 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.16NCBI
Mesp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,147,671 - 143,149,189 (-)NCBIGRCr8
mRatBN7.21133,738,357 - 133,739,875 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,738,357 - 133,739,875 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,647,506 - 141,649,024 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,816,911 - 148,818,429 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,734,607 - 141,736,125 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,532,390 - 141,533,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,532,390 - 141,533,908 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,493,452 - 142,494,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,571,777 - 135,573,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,650,456 - 135,651,437 (-)NCBI
Celera1125,801,663 - 125,803,181 (-)NCBICelera
Cytogenetic Map1q31NCBI
MESP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,296,679 - 79,298,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,001,684 - 83,003,058 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,440,626 - 68,441,935 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,645,768 - 87,647,210 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,645,768 - 87,647,210 (-)Ensemblpanpan1.1panPan2
Mesp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,799,944 - 130,801,262 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,533,522 - 15,534,576 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,533,264 - 15,534,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MESP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,322,274 - 55,323,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,322,016 - 55,327,600 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,211,078 - 60,218,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MESP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,286,551 - 8,288,777 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,286,828 - 8,287,918 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605938,523,729 - 38,525,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in MESP1
13 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 11
Low 5 8 2 1 8 10 6
Below cutoff 4 8 5 5 5 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000043787   ⟹   ENSCAFP00000040947
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl352,738,366 - 52,739,755 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000854   ⟹   ENSCAFP00845000642
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl353,155,145 - 53,156,534 (-)Ensembl
RefSeq Acc Id: XM_003638970   ⟹   XP_003639018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1352,738,333 - 52,739,962 (-)NCBI
Dog10K_Boxer_Tasha355,372,284 - 55,373,854 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038471175   ⟹   XP_038327103
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1352,676,925 - 52,678,493 (-)NCBI
RefSeq Acc Id: XM_038532092   ⟹   XP_038388020
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0353,227,220 - 53,228,790 (-)NCBI
RefSeq Acc Id: XM_038596351   ⟹   XP_038452279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0352,886,866 - 52,888,431 (-)NCBI
RefSeq Acc Id: XM_038660545   ⟹   XP_038516473
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0353,155,122 - 53,156,692 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003639018   ⟸   XM_003638970
- UniProtKB: A0A8C0L171 (UniProtKB/TrEMBL),   A0A8P0NS27 (UniProtKB/TrEMBL),   A0A8C0Q6K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000040947   ⟸   ENSCAFT00000043787
RefSeq Acc Id: XP_038327103   ⟸   XM_038471175
RefSeq Acc Id: XP_038452279   ⟸   XM_038596351
RefSeq Acc Id: XP_038516473   ⟸   XM_038660545
- UniProtKB: A0A8I3MI31 (UniProtKB/TrEMBL),   A0A8C0Q6K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038388020   ⟸   XM_038532092
- UniProtKB: A0A8C0L171 (UniProtKB/TrEMBL),   A0A8C0Q6K9 (UniProtKB/TrEMBL),   A0A8P0NS27 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000642   ⟸   ENSCAFT00845000854
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030023 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040001612 UniProtKB/TrEMBL
  ENSCAFG00845000532 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000043787.3 UniProtKB/TrEMBL
  ENSCAFT00040003075.1 UniProtKB/TrEMBL
  ENSCAFT00845000854 ENTREZGENE
  ENSCAFT00845000854.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Mesogenin/MesP UniProtKB/TrEMBL
KEGG Report cfa:100856667 UniProtKB/TrEMBL
NCBI Gene MESP1 ENTREZGENE
PANTHER MESODERM POSTERIOR PROTEIN 1 UniProtKB/TrEMBL
  PTHR20937 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A8C0L171 ENTREZGENE
  A0A8C0Q6K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MI31 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NS27 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43163 ENTREZGENE