ERP44 (endoplasmic reticulum protein 44) - Rat Genome Database

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Gene: ERP44 (endoplasmic reticulum protein 44) Canis lupus familiaris
Analyze
Symbol: ERP44
Name: endoplasmic reticulum protein 44
RGD ID: 12326306
Description: ENCODES a protein that exhibits protein disulfide isomerase activity (inferred); INVOLVED IN glycoprotein metabolic process (inferred); protein folding (inferred); response to endoplasmic reticulum stress (inferred); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); congenital myasthenic syndrome 14 (ortholog); FOUND IN cell surface (inferred); endoplasmic reticulum lumen (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endoplasmic reticulum resident protein 44; LOC606772; TXNDC4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,957,064 - 57,039,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,958,817 - 57,039,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,389,180 - 55,483,471 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01158,066,652 - 58,161,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1158,065,994 - 58,160,997 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11156,570,877 - 56,665,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01156,595,729 - 56,690,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,295,165 - 57,389,544 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
ERP44
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,957,064 - 57,039,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,958,817 - 57,039,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1155,389,180 - 55,483,471 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01158,066,652 - 58,161,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1158,065,994 - 58,160,997 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11156,570,877 - 56,665,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01156,595,729 - 56,690,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01157,295,165 - 57,389,544 (-)NCBIUU_Cfam_GSD_1.0
ERP44
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,979,185 - 100,099,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,979,185 - 100,099,052 (-)EnsemblGRCh38hg38GRCh38
GRCh379102,741,467 - 102,861,282 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369101,781,282 - 101,901,151 (-)NCBINCBI36Build 36hg18NCBI36
Celera973,254,858 - 73,374,731 (-)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef972,340,490 - 72,460,508 (-)NCBIHuRef
CHM1_19102,887,925 - 103,007,771 (-)NCBICHM1_1
T2T-CHM13v2.09112,150,810 - 112,270,620 (-)NCBIT2T-CHM13v2.0
Erp44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39448,190,711 - 48,279,635 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl448,193,323 - 48,279,558 (-)EnsemblGRCm39 Ensembl
GRCm38448,190,711 - 48,279,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl448,193,323 - 48,279,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37448,206,203 - 48,292,461 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36448,215,467 - 48,300,658 (-)NCBIMGSCv36mm8
Celera448,215,114 - 48,301,229 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.09NCBI
Erp44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8567,313,245 - 67,406,207 (-)NCBIGRCr8
mRatBN7.2562,516,550 - 62,610,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl562,516,551 - 62,610,761 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx564,492,222 - 64,585,236 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0566,311,515 - 66,404,538 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0566,280,980 - 66,374,000 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,937,866 - 64,030,827 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,937,784 - 64,030,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0568,455,221 - 68,548,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4564,869,536 - 64,962,569 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1564,874,574 - 64,967,608 (-)NCBI
Celera564,984,853 - 65,077,468 (+)NCBICelera
Cytogenetic Map5q22NCBI
Erp44
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541925,584,404 - 25,665,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541925,584,404 - 25,665,590 (+)NCBIChiLan1.0ChiLan1.0
ERP44
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21139,362,223 - 39,481,896 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1939,364,594 - 39,484,267 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0971,062,078 - 71,185,195 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1999,182,352 - 99,301,938 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl999,182,352 - 99,301,938 (-)Ensemblpanpan1.1panPan2
Erp44
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,839,892 - 171,923,197 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365248,383,891 - 8,470,855 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365248,387,234 - 8,470,776 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERP44
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1241,785,146 - 241,897,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11241,788,801 - 241,897,432 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21270,077,943 - 270,216,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERP44
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11239,333,924 - 39,448,994 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1239,333,944 - 39,448,535 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660353,103,895 - 3,218,823 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erp44
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624825866,077 - 959,146 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624825865,901 - 962,661 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ERP44
568 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 20 5 5 5 6 10 8 10 6
Low 1 5 2 1 1 1 6 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022425023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038682274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000004017   ⟹   ENSCAFP00000003711
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1156,958,817 - 57,039,741 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014213   ⟹   ENSCAFP00845011019
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1158,065,994 - 58,160,997 (-)Ensembl
RefSeq Acc Id: XM_038490812   ⟹   XP_038346740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11156,570,877 - 56,665,156 (-)NCBI
RefSeq Acc Id: XM_038490813   ⟹   XP_038346741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11156,570,877 - 56,664,867 (-)NCBI
RefSeq Acc Id: XM_038490814   ⟹   XP_038346742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11156,570,877 - 56,649,487 (-)NCBI
RefSeq Acc Id: XM_038490815   ⟹   XP_038346743
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11156,571,920 - 56,664,402 (-)NCBI
RefSeq Acc Id: XM_038552933   ⟹   XP_038408861
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01157,295,165 - 57,389,544 (-)NCBI
RefSeq Acc Id: XM_038552934   ⟹   XP_038408862
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01157,295,165 - 57,389,255 (-)NCBI
RefSeq Acc Id: XM_038552935   ⟹   XP_038408863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01157,295,165 - 57,373,855 (-)NCBI
RefSeq Acc Id: XM_038552936   ⟹   XP_038408864
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01157,296,208 - 57,388,790 (-)NCBI
RefSeq Acc Id: XM_038616810   ⟹   XP_038472738
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01156,595,729 - 56,690,009 (-)NCBI
RefSeq Acc Id: XM_038616812   ⟹   XP_038472740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01156,595,729 - 56,689,720 (-)NCBI
RefSeq Acc Id: XM_038616813   ⟹   XP_038472741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01156,595,729 - 56,674,289 (-)NCBI
RefSeq Acc Id: XM_038616814   ⟹   XP_038472742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01156,596,772 - 56,689,255 (-)NCBI
RefSeq Acc Id: XM_038667515   ⟹   XP_038523443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1155,389,180 - 55,483,471 (-)NCBI
RefSeq Acc Id: XM_038667523   ⟹   XP_038523451
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1155,389,180 - 55,483,182 (-)NCBI
RefSeq Acc Id: XM_038667529   ⟹   XP_038523457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1155,389,180 - 55,467,787 (-)NCBI
RefSeq Acc Id: XM_038667534   ⟹   XP_038523462
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1155,390,223 - 55,482,717 (-)NCBI
RefSeq Acc Id: XM_038682271   ⟹   XP_038538199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01158,066,652 - 58,161,012 (-)NCBI
RefSeq Acc Id: XM_038682272   ⟹   XP_038538200
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01158,066,652 - 58,160,723 (-)NCBI
RefSeq Acc Id: XM_038682273   ⟹   XP_038538201
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01158,066,652 - 58,145,244 (-)NCBI
RefSeq Acc Id: XM_038682274   ⟹   XP_038538202
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01158,067,695 - 58,160,258 (-)NCBI
RefSeq Acc Id: ENSCAFP00000003711   ⟸   ENSCAFT00000004017
RefSeq Acc Id: XP_038346740   ⟸   XM_038490812
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038346741   ⟸   XM_038490813
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038346742   ⟸   XM_038490814
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038346743   ⟸   XM_038490815
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038472738   ⟸   XM_038616810
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038472740   ⟸   XM_038616812
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038472741   ⟸   XM_038616813
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038472742   ⟸   XM_038616814
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038538199   ⟸   XM_038682271
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P2G7 (UniProtKB/TrEMBL),   A0A8C0R3W8 (UniProtKB/TrEMBL),   A0A8I3N2H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538200   ⟸   XM_038682272
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038538201   ⟸   XM_038682273
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038538202   ⟸   XM_038682274
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038523443   ⟸   XM_038667515
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P2G7 (UniProtKB/TrEMBL),   A0A8C0R3W8 (UniProtKB/TrEMBL),   A0A8I3N2H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038523451   ⟸   XM_038667523
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038523457   ⟸   XM_038667529
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038523462   ⟸   XM_038667534
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038408861   ⟸   XM_038552933
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P2G7 (UniProtKB/TrEMBL),   A0A8C0R3W8 (UniProtKB/TrEMBL),   A0A8I3N2H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408862   ⟸   XM_038552934
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038408863   ⟸   XM_038552935
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038408864   ⟸   XM_038552936
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCAFP00845011019   ⟸   ENSCAFT00845014213
Protein Domains
Thioredoxin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002542 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019114 UniProtKB/TrEMBL
  ENSCAFG00040020380 UniProtKB/TrEMBL
  ENSCAFG00845008068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004017.6 UniProtKB/TrEMBL
  ENSCAFT00030035153.1 UniProtKB/TrEMBL
  ENSCAFT00040037711.1 UniProtKB/TrEMBL
  ENSCAFT00845014213 ENTREZGENE
  ENSCAFT00845014213.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro ERp44_PDI_b UniProtKB/TrEMBL
  ERp44_PDI_b UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
NCBI Gene ERP44 ENTREZGENE
PANTHER ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 UniProtKB/TrEMBL
  ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
  Thioredoxin_6 UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0P2G7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R3W8 ENTREZGENE
  A0A8I3N2H6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:51716 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 ERP44  endoplasmic reticulum protein 44  LOC606772  endoplasmic reticulum resident protein 44  Data merged from RGD:12314983 737654 PROVISIONAL