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Gene: SLIT1 (slit guidance ligand 1) Canis lupus familiaris

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Symbol:

SLIT1

Name:

slit guidance ligand 1

RGD ID:

12325992

Description:

ENCODES a protein that exhibits heparan sulfate proteoglycan binding (ortholog); INVOLVED IN axon guidance (ortholog); axonogenesis (ortholog); chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration (ortholog); ASSOCIATED WITH Brain Injuries (ortholog); Monomelic Amyotrophy (ortholog); Spinal Cord Injuries (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

slit homolog 1 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLIT1 (slit guidance ligand 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slit1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Slit1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slit1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLIT1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slit1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLIT1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLIT1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slit1 (slit guidance ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLIT2 (slit guidance ligand 2)	HGNC	OrthoDB

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	10,351,758 - 10,519,322 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	10,351,821 - 10,519,313 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	10,535,122 - 10,702,300 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	10,673,425 - 10,840,914 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	10,673,458 - 10,840,953 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	10,335,078 - 10,502,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	10,395,529 - 10,563,416 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	10,536,093 - 10,703,522 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain Injuries (ISO)

Monomelic Amyotrophy (ISO)

Spinal Cord Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon extension involved in axon guidance (IEA)

axon guidance (IEA,ISO)

axonogenesis (IEA,ISO)

cell differentiation (IEA)

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration (ISO)

dorsal/ventral axon guidance (IEA,ISO)

motor neuron axon guidance (IEA)

negative chemotaxis (IBA,IEA,ISO)

negative regulation of axon extension involved in axon guidance (ISO)

nervous system development (IEA)

neuron projection morphogenesis (IEA,ISO)

nuclear migration (IEA,ISO)

olfactory bulb development (IEA,ISO)

retinal ganglion cell axon guidance (IEA,ISO)

spinal cord development (ISO)

tangential migration from the subventricular zone to the olfactory bulb (IEA,ISO)

telencephalon cell migration (IEA,ISO)

Cellular Component

extracellular space (IBA,IEA,ISO)

Molecular Function

calcium ion binding (IEA)

heparan sulfate proteoglycan binding (ISO)

heparin binding (IBA)

protein binding (ISO)

Roundabout binding (IBA,IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SLIT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	10,351,758 - 10,519,322 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	10,351,821 - 10,519,313 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	10,535,122 - 10,702,300 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	10,673,425 - 10,840,914 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	10,673,458 - 10,840,953 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	10,335,078 - 10,502,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	10,395,529 - 10,563,416 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	10,536,093 - 10,703,522 (-)	NCBI		UU_Cfam_GSD_1.0

SLIT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	96,998,038 - 97,185,959 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	96,998,038 - 97,185,959 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	98,757,795 - 98,945,716 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	98,750,601 - 98,935,653 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	98,750,600 - 98,935,653	NCBI
Celera	10	92,499,394 - 92,687,283 (-)	NCBI		Celera
Cytogenetic Map	10	q24.1	NCBI
HuRef	10	92,385,891 - 92,573,726 (-)	NCBI		HuRef
CHM1_1	10	99,040,092 - 99,227,937 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	97,878,923 - 98,066,822 (-)	NCBI		T2T-CHM13v2.0

Slit1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	41,586,263 - 41,735,714 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	41,588,696 - 41,732,104 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	41,597,824 - 41,747,275 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	41,600,257 - 41,743,665 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	41,674,747 - 41,818,346 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	41,653,570 - 41,797,167 (-)	NCBI		MGSCv36	mm8
Celera	19	42,398,288 - 42,542,154 (-)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	34.99	NCBI

Slit1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	250,358,917 - 250,507,476 (-)	NCBI		GRCr8
mRatBN7.2	1	240,409,559 - 240,558,127 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	240,409,561 - 240,558,127 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	248,552,721 - 248,697,784 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	255,249,868 - 255,394,935 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	247,902,887 - 248,047,946 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	260,843,481 - 260,992,366 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	260,843,483 - 260,992,366 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	268,298,678 - 268,445,090 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	246,813,909 - 246,964,408 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	246,928,385 - 247,078,883 (-)	NCBI
Celera	1	236,249,200 - 236,395,640 (-)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

Slit1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	3,201,556 - 3,365,471 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955507	3,204,135 - 3,365,319 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLIT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	108,910,729 - 109,098,440 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	108,916,049 - 109,103,762 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	93,618,550 - 93,806,263 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	97,116,073 - 97,303,406 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	97,119,133 - 97,303,095 (-)	Ensembl	panpan1.1		panPan2

Slit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	36,388,622 - 36,543,449 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936636	2,427,736 - 2,582,578 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936636	2,427,738 - 2,582,565 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLIT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	108,446,004 - 108,624,302 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	108,446,003 - 108,624,508 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	118,083,559 - 118,149,597 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLIT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	90,166,710 - 90,357,983 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	90,172,578 - 90,237,256 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	51,061,333 - 51,250,208 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slit1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	8,460,508 - 8,632,302 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	8,458,444 - 8,632,316 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SLIT1
2056 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005637583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022411625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038440163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038514776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038578405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038642571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000014303 ⟹ ENSCAFP00000013226

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	10,351,821 - 10,519,313 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000085689 ⟹ ENSCAFP00000054472

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	10,399,728 - 10,519,313 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000091774 ⟹ ENSCAFP00000064564

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	10,352,469 - 10,519,313 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845049432 ⟹ ENSCAFP00845038784

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	10,673,458 - 10,840,953 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845049678 ⟹ ENSCAFP00845038962

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	10,673,458 - 10,840,953 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845049829 ⟹ ENSCAFP00845039078

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	10,673,458 - 10,840,953 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050072 ⟹ ENSCAFP00845039260

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	10,674,127 - 10,840,953 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845050310 ⟹ ENSCAFP00845039441

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	10,721,422 - 10,840,953 (-)	Ensembl

RefSeq Acc Id:

XM_005637583 ⟹ XP_005637640

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	28	10,351,758 - 10,519,319 (-)	NCBI
Dog10K_Boxer_Tasha	28	10,535,122 - 10,702,300 (-)	NCBI

Sequence:

show sequence

GGATGACTGCTGGGTGAGAGCGAGCGTGCGGGTGTGAGTGTGTGGTTGCGCGTGTGTGCGCGGG
GTGCGTGCGCGCGCGGGGCCTGCCCATTTTCCTCCTCGCAGCAGTCAGTTGGGAGCTGGAGGGA
GGGAGAGCGGGAGACGCCGCCGGCGAGGAGCCGAGGAGGAGCCAGCGCCCTCCGCCAAGGCGCC
CTCGCTCGGTCCGCGCACGGACGCCGTCGCTCGGGGGAGCAGGGCGCCTCCCAGCCCCTAAGGG
CGGCGCTGCCCGGGCTGCACCTGGAGGCCCCCGGGCGGGGATGGTCAGCGGCTGCCGCGGGCCG
GCGCACGAGCGGACGCGGCGAGGGCACCATGGCGCTGGCGCCCCGGAGGGGGCCCCCGGCGCGG
CGCGTCCGGCCCGAGCTCTGGCTGCTGCTGTGGGCGGCCGCGTGGCGCCTGGGTGCCACGGCGT
GCCCCGCGCTCTGCACCTGCACGGGCGCCACGGTGGACTGCCACGGCGCGGGGCTGCAGGCCAT
CCCGAAGAACATCCCGCGGAGCACCGAGCGCCTGGAACTCAATGGCAACAACATCACTCGGATC
CACAAAAATGACTTCGTGGGGCTCAAGCAGCTGCGAGTGCTGCAGCTGATGGAGAACCAGATTG
GAGTGGTGGAACGGGGGGCTTTTGACGACATGAAGGAGCTGGAGCGGCTACGACTGAACCGGAA
CCAGCTCCACACGTTGCCAGAACTGCTGTTCCAGAATAACCAGGCTCTTTCGAGACTGGACCTG
AGTGAGAACACAATCCAGGCCATCCCCAGAAAAGCTTTTCGTGGAGCTACAGACCTCAAAAATT
TACAGCTGGACAAGAACCAGATTAGCTGCATCGAGGAAGGAGCCTTCCGGGCTCTGCGGGGGCT
GGAGGTGCTGACCCTGAACAACAACAACATCACCACCATCCCTGTGTCCAGCTTCAACCACATG
CCCAAGCTGCGGACCTTCCGCCTGCACTCCAACCATCTGTTCTGCGACTGCCACCTGGCCTGGC
TCTCACAGTGGCTGAGGCAGCGGCCAACCATCGGGCTCTTCACCCAGTGCTCAGGCCCCGCCAG
CCTGCGTGGCCTCAACGTGGCTGAGGTCCAGAAGAGTGAGTTCAGCTGCTCAGGCCAAGGGGAG
GCGGGGCGAGTGCCTTCCTGCACCCTTTCCTCTGGCTCCTGCCCGGCCATGTGCTCCTGCAGCA
ACGGCATTGTGGACTGTCGCGGCAAAGGCCTCACCGCCATCCCCGCCAACCTGCCTGAGACCAT
GACGGAGATACGCCTGGAGCTCAATGGGATCAAGTCCATCCCCCCAGGAGCCTTCTCTCCCTAC
AGAAAGCTGCGGAGGATAGACCTGAGCAACAACCAGATTGCAGAAATCGCGCCCGATGCCTTCC
AGGGCCTCCGCTCCCTGAACTCGCTGGTCCTGTATGGGAACAAGATCACAGACCTCCCCCGGGG
TGTGTTTGGAGGCTTGTACACCCTACAGCTCCTGCTCTTGAACGCCAACAAGATCAACTGTGTC
CGGCCCGATGCCTTCCAGGATCTGCAGAACCTCTCACTTCTCTCCCTGTATGACAACAAGATCC
AGAGCCTTGCCAAGGGCACCTTCACCTCCCTGAGGGCTATCCAAACCCTGCATCTGGCCCAGAA
CCCTTTCATCTGTGACTGTAACCTCAAGTGGCTGGCGGACTTCCTGCGCACCAACCCCATCGAG
ACGAGCGGGGCCCGCTGTGCCAGCCCTCGACGCCTTGCCAACAAGCGCATCGGGCAGATCAAGA
GCAAGAAGTTCCGGTGCTCAGCCAAAGAGCAGTACTTCATTCCAGGCACAGAGGACTACCAGCT
GAACAGCGAGTGCAACAGCGACGCAGTCTGTCCCCACAAGTGCCGCTGTGAGGCCAGCCTGGCC
GAGTGCTCCAGCCTGAAGCTCACCAAGATCCCAGAGCGCATCCCCCAGTCCACGGCTGAGCTAC
GATTAAACAACAATGAGATTTCCATCCTGGAGGCCACTGGGATATTTAAAAAACTCACTCATCT
GAAGAAGATCAATCTGAGCAACAACAAGGTGTCGGAAATCGAAGATGGGGCCTTCGAGGGCGCC
GCCTCTGTGAGCGAGCTGCACCTGACGGCCAACCAGCTGGAGTCCATCCGGAGCGGCATGTTCC
GGGGCCTGGACGGCTTGAGGACCCTGATGCTGAGGAACAACCGTATTAGCTGCATCCACAACGA
CAGCTTCACAGGCCTGCGCAACGTCCGCCTCCTCTCGCTCTATGACAACCAGATCGCCACCATC
TCCCCCGGGGCCTTCGACACCCTGCAGGCCCTGTCCACGCTAAACCTCCTGGCCAACCCTTTCA
ACTGCAACTGCCAGCTGGCCTGGCTTGGCGACTGGCTGCGGAGGAGGAAGATCGTGACAGGGAA
CCCACGGTGCCAGAACCCAGATTTCTTGAGGCAGATCCCCCTGCAGGACGTGGCCTTCCCTGAC
TTCAGGTGCGAGGAAGGCCAGGAAGAGGGGAGCTGCCTGCCCCGCCCACAGTGCCCCCAGGAAT
GTGCCTGCCTGGACACCGTGGTCCGATGCAGCAACAAGCACCTCCACGTCCTGCCCAAGGGCAT
CCCCAAGAATGTCACAGAACTCTACTTGGACGGGAACCAGTTCACACTGGTTCCGGGACAGCTG
TCCACCTTCAAGTACCTGCAGCTTGTGGACTTGAGTAACAACAAGATCAGCTCCTTAAGCAATT
CCTCCTTCACCAACATGAGCCAGCTGACCACTCTGATCCTCAGCTACAATGCCCTCCAGTGTAT
CCCTCCTCTGGCCTTCCAGGGGCTGCGCTCCCTGCGTCTGCTGTCCCTGCATGGCAATGACATC
TCCACCCTCCGAGAGGGCATCTTCACAGACGTGACCTCCCTGTCTCACCTGGCCATTGGCGCCA
ACCCTCTGTACTGTGACTGCCATCTCCGCTGGCTGTCCAGCTGGGTGAAGACAGGCTATAAGGA
GCCAGGCATTGCCCGCTGTGTGGGGCCCCCAGACATGGAGGGCAAGCTGCTCCTCACCACACCT
GCCAAGAAGTTTGAATGCCAAGGTCCCCCCACCCTGGCTGTCCAGGCCAAGTGCGATCCCTGCT
TATCCAGCCCGTGCCGGAACCAGGGCACCTGCCATAACGACCCCCTGGAGGTGTACAGGTGTGT
CTGCTCCAGTGGCTATAAGGGCCGAGACTGCGAAGTATCCCTGGATGGCTGTTCCAGCAGCCCC
TGTGGAAATGGAGGGACCTGCCGCCCACAGGAGGGCGGGGACGCCGGGTTCACGTGTTCCTGTC
CCCCCGGCTTTGAAGGCCCAACCTGTGAGGTGAATACGGATGACTGTGTGGAGCACACATGCGC
CAATGGGGGTATCTGTGTGGATGGTGTGGGCAACTACACCTGCCAGTGCCCCCTACAGTACACG
GGAAGGGGCTGTGAGCAGCTGGTGGACTTCTGCTCCTCAGATTTGAACCCGTGTCAGCACGAGG
CCCAGTGTGTGGGTACTCCAGATGGGCCCAGGTGTGAGTGTGCACCAGGTTACGTGGGTGACAA
CTGCAGTGAGAACCAGGATGACTGCAGGGATCACCGCTGCCAGCATGGGGCCCAGTGTGTGGAT
GAAGTCAACAGCTACTCCTGCCTCTGTGCTGAGGGCTACAGCGGGCAGTTCTGTGAGGCCCCTC
CCCGCCCTCCTGCCCCCAGAAGCCCCTGCGAGGGGACAGAGTGCCAGAATGGGGCCAACTGTGT
GGACCAGGGCAGTGGGCCTGTGTGCCAGTGCCTCCCAGGCTTCGGCGGCCCCGAGTGTGAGAAG
TTGCTCAGTGTCAACTTTGTGGATCGGGACACCTACCTGCAGTTCACTGACCTGCAGAATTGGC
CCCGGGCCAACATCACGCTGCAGGTCTCCACGGCAGAGGACAATGGGATCTTGCTGTACAATGG
AGACAATGACCACATGGCAGTGGAGCTGTACCAGGGTCACGTGCGTGTCAGCTATGACCCGGGC
AGCTACCCCAGCTCGGCCATCTACAGTGCCGAGACGATCAATGATGGACAGTTCCACACCGTTG
AGCTGGTCACCTTTGACCAGATGGTGAATCTCTCCATTGATGGAGGCAGTCCCATGACCATGGA
CAATTTTGGCAAACACTACACACTAAACAGCGAAGCTCCCCTCTACGTGGGAGGGATGCCAGTG
GATGTGAACTCAGCCGCCTTCCGCCTGTGGCAGATCCTCAACGGCACCAGCTTCCACGGTTGCA
TCCGAAACCTATACATCAACAATGAGCTGCAGGACTTCACTAAGACGCGGATGAAGCCAGGCGT
GGTGCCAGGCTGTGAGCCCTGCCGAAAGCTCTACTGCCTGCATGGCATCTGCCAGCCCAATGCC
ACCCCGGGGCCTGTGTGCCATTGTGAGGCCGGCTGGGGGGGCCTACACTGTGACCAGCCAGCCG
ATGGCCCCTGCCATGGCCACAAGTGTGTCCACGGAAAATGTGTGCCCCTCGACGCTCTTTCCTA
CAGCTGCCAGTGCCAGGATGGGTACTCGGGGGCTTTGTGCAACCAGGCGAGGGCACCTGCAGAT
CCTTGTGGGGGCCTGCAGTGCCTACATGGCCACTGCCAGGTCTTGGCCACCAAGGGGGCACACT
GTGTGTGTGACCCCGGTTTTTCGGGCGAGCTGTGTGAGCAAGAGTCCGAGTGCCGGGGGGACCC
TGTCCGGGACTTTCACCAGGTCCAGAGGGGCTATGCCATCTGCCAGACCACGCGCCCGCTGTCG
TGGGTGGAGTGCCGGGGCTCCTGCCCAGGTCAGGGCTGCTGCCAGGGCCTGCGGCTGAAGCGGA
GGAAGCTCACCTTTGAGTGCAGCGACGGGACCTCTTTTGCCGAGGAGGTGGAGAAGCCCACCAA
GTGCGGCTGCGCCGTCTGCGCCTAGCGCCGGGCTGGACGGGGAGGGGTGAGGCGGGCACGGGGC
ACGGCTGCGGGGCTGCGGGTCGGT

hide sequence

RefSeq Acc Id:

XM_038440163 ⟹ XP_038296091

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	28	10,673,425 - 10,840,914 (-)	NCBI

RefSeq Acc Id:

XM_038514776 ⟹ XP_038370704

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	28	10,335,078 - 10,502,567 (-)	NCBI

RefSeq Acc Id:

XM_038578405 ⟹ XP_038434333

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	28	10,536,093 - 10,703,522 (-)	NCBI

RefSeq Acc Id:

XM_038642571 ⟹ XP_038498499

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	28	10,395,529 - 10,563,416 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005637640	(Get FASTA)	NCBI Sequence Viewer
	XP_038296091	(Get FASTA)	NCBI Sequence Viewer
	XP_038370704	(Get FASTA)	NCBI Sequence Viewer
	XP_038434333	(Get FASTA)	NCBI Sequence Viewer
	XP_038498499	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000013226.3
	ENSCAFP00000054472.1
	ENSCAFP00000064564.1
	ENSCAFP00030037919.1
	ENSCAFP00040040866.1
	ENSCAFP00040040920.1
	ENSCAFP00040040970.1
	ENSCAFP00845038784
	ENSCAFP00845038784.1
	ENSCAFP00845038962.1
	ENSCAFP00845039078.1
	ENSCAFP00845039260.1
	ENSCAFP00845039441.1

RefSeq Acc Id:

XP_005637640 ⟸ XM_005637583

- UniProtKB:

A0A8C0TQL4 (UniProtKB/TrEMBL), A0A8I3PVG4 (UniProtKB/TrEMBL), A0A8C0TV04 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALAPRRGPPARRVRPELWLLLWAAAWRLGATACPALCTCTGATVDCHGAGLQAIPKNIPRSTE
RLELNGNNITRIHKNDFVGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNQLHTLPELL
FQNNQALSRLDLSENTIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNN
ITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEV
QKSEFSCSGQGEAGRVPSCTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNG
IKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQ
LLLLNANKINCVRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLK
WLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDAV
CPHKCRCEASLAECSSLKLTKIPERIPQSTAELRLNNNEISILEATGIFKKLTHLKKINLSNNK
VSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVR
LLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRRRKIVTGNPRCQNPDFL
RQIPLQDVAFPDFRCEEGQEEGSCLPRPQCPQECACLDTVVRCSNKHLHVLPKGIPKNVTELYL
DGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLR
SLRLLSLHGNDISTLREGIFTDVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCVGP
PDMEGKLLLTTPAKKFECQGPPTLAVQAKCDPCLSSPCRNQGTCHNDPLEVYRCVCSSGYKGRD
CEVSLDGCSSSPCGNGGTCRPQEGGDAGFTCSCPPGFEGPTCEVNTDDCVEHTCANGGICVDGV
GNYTCQCPLQYTGRGCEQLVDFCSSDLNPCQHEAQCVGTPDGPRCECAPGYVGDNCSENQDDCR
DHRCQHGAQCVDEVNSYSCLCAEGYSGQFCEAPPRPPAPRSPCEGTECQNGANCVDQGSGPVCQ
CLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHMAVEL
YQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLN
SEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTRMKPGVVPGCEPCRK
LYCLHGICQPNATPGPVCHCEAGWGGLHCDQPADGPCHGHKCVHGKCVPLDALSYSCQCQDGYS
GALCNQARAPADPCGGLQCLHGHCQVLATKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQR
GYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAVCA

hide sequence

Ensembl Acc Id:

ENSCAFP00000013226 ⟸ ENSCAFT00000014303

Ensembl Acc Id:

ENSCAFP00000064564 ⟸ ENSCAFT00000091774

Ensembl Acc Id:

ENSCAFP00000054472 ⟸ ENSCAFT00000085689

RefSeq Acc Id:

XP_038370704 ⟸ XM_038514776

RefSeq Acc Id:

XP_038498499 ⟸ XM_038642571

RefSeq Acc Id:	XP_038296091 ⟸ XM_038440163
- UniProtKB:	A0A8C0TQL4 (UniProtKB/TrEMBL), A0A8I3PVG4 (UniProtKB/TrEMBL), A0A8C0TV04 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038434333 ⟸ XM_038578405
- UniProtKB:	A0A8C0TQL4 (UniProtKB/TrEMBL), A0A8C0TV04 (UniProtKB/TrEMBL), A0A8I3PVG4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845038962 ⟸ ENSCAFT00845049678

Ensembl Acc Id:

ENSCAFP00845038784 ⟸ ENSCAFT00845049432

Ensembl Acc Id:

ENSCAFP00845039078 ⟸ ENSCAFT00845049829

Ensembl Acc Id:

ENSCAFP00845039260 ⟸ ENSCAFT00845050072

Ensembl Acc Id:

ENSCAFP00845039441 ⟸ ENSCAFT00845050310

Protein Domains

CTCK EGF-like Laminin G LRRCT LRRNT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000008945	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030023618	UniProtKB/TrEMBL
	ENSCAFG00040025102	UniProtKB/TrEMBL
	ENSCAFG00845027970	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000014303.5	UniProtKB/TrEMBL
	ENSCAFT00000085689.2	UniProtKB/TrEMBL
	ENSCAFT00000091774.2	UniProtKB/TrEMBL
	ENSCAFT00030043436.1	UniProtKB/TrEMBL
	ENSCAFT00040046816.1	UniProtKB/TrEMBL
	ENSCAFT00040046879.1	UniProtKB/TrEMBL
	ENSCAFT00040046931.1	UniProtKB/TrEMBL
	ENSCAFT00845049432	ENTREZGENE
	ENSCAFT00845049432.1	UniProtKB/TrEMBL
	ENSCAFT00845049678.1	UniProtKB/TrEMBL
	ENSCAFT00845049829.1	UniProtKB/TrEMBL
	ENSCAFT00845050072.1	UniProtKB/TrEMBL
	ENSCAFT00845050310.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/TrEMBL
	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	Cys_knot_C	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_CS	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Fol_N	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	Laminin_G	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	LRR_TM_domain-containing	UniProtKB/TrEMBL
	LRRNT	UniProtKB/TrEMBL
	Neurexin-related_CASP	UniProtKB/TrEMBL
	Notch/Slit_guidance	UniProtKB/TrEMBL
KEGG Report	cfa:486818	UniProtKB/TrEMBL
NCBI Gene	SLIT1	ENTREZGENE
PANTHER	ANTIGEN BSP, PUTATIVE-RELATED	UniProtKB/TrEMBL
	KON-TIKI, ISOFORM B	UniProtKB/TrEMBL
	LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE	UniProtKB/TrEMBL
	PIKACHURIN-LIKE PROTEIN	UniProtKB/TrEMBL
	SLIT HOMOLOG	UniProtKB/TrEMBL
	SLIT HOMOLOG 1 PROTEIN	UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/TrEMBL
	hEGF	UniProtKB/TrEMBL
	Laminin_G_2	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
	LRRNT	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	CTCK_1	UniProtKB/TrEMBL
	CTCK_2	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LAM_G_DOMAIN	UniProtKB/TrEMBL
	LRR	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	FOLN	UniProtKB/TrEMBL
	LamG	UniProtKB/TrEMBL
	LRR_SD22	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
	LRRNT	UniProtKB/TrEMBL
	SM00041	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	L domain-like	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A8C0TQL4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0TV04	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0Z6V1_CANLF	UniProtKB/TrEMBL
	A0A8I3PVB3_CANLF	UniProtKB/TrEMBL
	A0A8I3PVG4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3Q3V6_CANLF	UniProtKB/TrEMBL
	A0A8I3QGC0_CANLF	UniProtKB/TrEMBL
	A0A8I3S6L3_CANLF	UniProtKB/TrEMBL
	A0A8P0P417_CANLF	UniProtKB/TrEMBL
	Q59I58_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:53014	ENTREZGENE

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar