FBLN5 (fibulin 5) - Rat Genome Database

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Gene: FBLN5 (fibulin 5) Canis lupus familiaris
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Symbol: FBLN5
Name: fibulin 5
RGD ID: 12325358
Description: ENCODES a protein that exhibits integrin binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); intramembranous bone growth (ortholog); negative regulation of angiogenesis (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); adult respiratory distress syndrome (ortholog); age related macular degeneration (ortholog); FOUND IN elastic fiber (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fibulin-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,162,203 - 1,231,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,162,923 - 1,231,719 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,181,396 - 1,250,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,211,329 - 1,280,901 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,211,330 - 1,280,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,149,346 - 1,218,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,105,810 - 1,175,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,226,613 - 1,296,196 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
FBLN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,162,203 - 1,231,809 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,162,923 - 1,231,719 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,181,396 - 1,250,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,211,329 - 1,280,901 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,211,330 - 1,280,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,149,346 - 1,218,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,105,810 - 1,175,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,226,613 - 1,296,196 (-)NCBIUU_Cfam_GSD_1.0
FBLN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381491,869,411 - 91,947,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1491,869,411 - 91,947,987 (-)EnsemblGRCh38hg38GRCh38
GRCh371492,335,755 - 92,414,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,405,508 - 91,483,788 (-)NCBINCBI36Build 36hg18NCBI36
Build 341491,405,508 - 91,483,788NCBI
Celera1472,388,374 - 72,466,655 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,516,509 - 72,594,687 (-)NCBIHuRef
CHM1_11492,273,834 - 92,352,362 (-)NCBICHM1_1
T2T-CHM13v2.01486,098,901 - 86,177,154 (-)NCBIT2T-CHM13v2.0
Fbln5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912101,712,820 - 101,785,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12101,712,824 - 101,785,314 (-)EnsemblGRCm39 Ensembl
GRCm3812101,746,565 - 101,819,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12101,746,565 - 101,819,055 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712102,984,775 - 103,057,265 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,147,615 - 102,228,101 (-)NCBIMGSCv36mm8
Celera12102,955,562 - 103,028,678 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.29NCBI
Fbln5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,664,100 - 126,742,847 (-)NCBIGRCr8
mRatBN7.26120,899,219 - 120,977,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6120,899,224 - 120,977,755 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,049,874 - 121,128,342 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,346,562 - 121,425,038 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,681,448 - 120,759,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,644,797 - 125,723,957 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,644,804 - 125,723,944 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06134,856,694 - 134,935,853 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,018,541 - 126,098,234 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,022,288 - 126,102,052 (-)NCBI
Celera6118,399,373 - 118,476,665 (-)NCBICelera
Cytogenetic Map6q32NCBI
Fbln5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,071,410 - 14,145,070 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,073,927 - 14,144,644 (-)NCBIChiLan1.0ChiLan1.0
FBLN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,027,865 - 93,106,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,244,375 - 92,323,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,504,240 - 72,583,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11491,848,430 - 91,927,470 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1491,848,430 - 91,927,304 (-)Ensemblpanpan1.1panPan2
Fbln5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864013,257,820 - 13,330,662 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733137,207 - 209,473 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733136,374 - 200,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBLN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,423,632 - 113,512,198 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17113,423,629 - 113,526,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,031,698 - 120,120,256 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBLN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12469,626,498 - 69,703,146 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2469,626,339 - 69,703,108 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605356,876,363 - 56,952,959 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbln5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473410,768,751 - 10,843,654 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473410,768,920 - 10,840,740 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FBLN5
637 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 22 6 6 6 6 12 10 6
Low 1 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000017276   ⟹   ENSCAFP00000015987
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl81,162,923 - 1,228,476 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061833   ⟹   ENSCAFP00000050472
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl81,162,923 - 1,231,719 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034740   ⟹   ENSCAFP00845027207
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl81,211,330 - 1,280,859 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034871   ⟹   ENSCAFP00845027309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl81,211,330 - 1,278,481 (-)Ensembl
RefSeq Acc Id: XM_038482692   ⟹   XP_038338620
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.181,149,346 - 1,218,919 (-)NCBI
RefSeq Acc Id: XM_038544113   ⟹   XP_038400041
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.081,226,613 - 1,296,196 (-)NCBI
RefSeq Acc Id: XM_038608239   ⟹   XP_038464167
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.081,105,810 - 1,175,344 (-)NCBI
RefSeq Acc Id: XM_038673043   ⟹   XP_038528971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.081,211,329 - 1,280,901 (-)NCBI
RefSeq Acc Id: XM_537350   ⟹   XP_537350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.181,162,203 - 1,231,809 (-)NCBI
Dog10K_Boxer_Tasha81,181,396 - 1,250,913 (-)NCBI
Sequence:
RefSeq Acc Id: XP_537350   ⟸   XM_537350
- UniProtKB: A0A8C0M0J8 (UniProtKB/TrEMBL),   A0A8C0L7A7 (UniProtKB/TrEMBL),   A0A8I3NZL0 (UniProtKB/TrEMBL),   A0A8I3PA99 (UniProtKB/TrEMBL),   A0A8P0ND12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000015987   ⟸   ENSCAFT00000017276
RefSeq Acc Id: ENSCAFP00000050472   ⟸   ENSCAFT00000061833
RefSeq Acc Id: XP_038338620   ⟸   XM_038482692
RefSeq Acc Id: XP_038464167   ⟸   XM_038608239
RefSeq Acc Id: XP_038528971   ⟸   XM_038673043
- UniProtKB: A0A8C0M0J8 (UniProtKB/TrEMBL),   A0A8C0L7A7 (UniProtKB/TrEMBL),   A0A8I3NZL0 (UniProtKB/TrEMBL),   A0A8I3PA99 (UniProtKB/TrEMBL),   A0A8P0ND12 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400041   ⟸   XM_038544113
- UniProtKB: A0A8C0L7A7 (UniProtKB/TrEMBL),   A0A8C0M0J8 (UniProtKB/TrEMBL),   A0A8I3NZL0 (UniProtKB/TrEMBL),   A0A8I3PA99 (UniProtKB/TrEMBL),   A0A8P0ND12 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845027207   ⟸   ENSCAFT00845034740
RefSeq Acc Id: ENSCAFP00845027309   ⟸   ENSCAFT00845034871
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010853 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001391 UniProtKB/TrEMBL
  ENSCAFG00040016446 UniProtKB/TrEMBL
  ENSCAFG00845019694 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017276.5 UniProtKB/TrEMBL
  ENSCAFT00000061833.2 UniProtKB/TrEMBL
  ENSCAFT00030002491.1 UniProtKB/TrEMBL
  ENSCAFT00040030368.1 UniProtKB/TrEMBL
  ENSCAFT00845034740 ENTREZGENE
  ENSCAFT00845034740.1 UniProtKB/TrEMBL
  ENSCAFT00845034871.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro cEGF UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
NCBI Gene FBLN5 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam cEGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
PRINTS THRMBOMODULN UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0L7A7 ENTREZGENE
  A0A8C0M0J8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NZL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PA99 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0ND12 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40752 ENTREZGENE