PRKX (protein kinase X-linked) - Rat Genome Database

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Gene: PRKX (protein kinase X-linked) Canis lupus familiaris
Analyze
Symbol: PRKX
Name: protein kinase X-linked
RGD ID: 12324334
Description: ENCODES a protein that exhibits ATP binding (inferred); cAMP-dependent protein kinase activity (inferred); protein kinase activity (inferred); INVOLVED IN angiogenesis (ortholog); cell adhesion (ortholog); cell-substrate adhesion (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-dependent protein kinase catalytic subunit PRKX; serine/threonine-protein kinase PRKX
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X1,938,205 - 2,007,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX1,945,379 - 2,014,661 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX1,888,783 - 1,962,819 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X1,864,516 - 1,938,512 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X1,856,007 - 1,929,869 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X1,871,602 - 1,945,594 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X1,899,988 - 1,973,995 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PRKX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X1,938,205 - 2,007,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX1,945,379 - 2,014,661 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX1,888,783 - 1,962,819 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X1,864,516 - 1,938,512 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X1,856,007 - 1,929,869 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X1,871,602 - 1,945,594 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X1,899,988 - 1,973,995 (-)NCBIUU_Cfam_GSD_1.0
PRKX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X3,604,340 - 3,713,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX3,604,340 - 3,713,649 (-)EnsemblGRCh38hg38GRCh38
GRCh37X3,522,381 - 3,631,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X3,532,411 - 3,641,661 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X3,515,771 - 3,625,010NCBI
CeleraX7,803,269 - 7,912,726 (-)NCBICelera
Cytogenetic MapXp22.33NCBI
HuRefX1,474,445 - 1,580,609 (-)NCBIHuRef
CHM1_1X3,552,929 - 3,661,974 (-)NCBICHM1_1
T2T-CHM13v2.0X3,218,669 - 3,333,048 (-)NCBIT2T-CHM13v2.0
Prkx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X76,804,578 - 76,839,545 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX76,805,017 - 76,839,884 (-)EnsemblGRCm39 Ensembl
GRCm38X77,760,972 - 77,796,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX77,761,411 - 77,796,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X75,007,362 - 75,041,299 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X74,014,742 - 74,048,679 (-)NCBIMGSCv36mm8
CeleraX69,092,716 - 69,127,190 (-)NCBICelera
Cytogenetic MapXBNCBI
cM MapX38.32NCBI
Prkx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X45,701,747 - 45,745,210 (-)NCBIGRCr8
mRatBN7.2X41,823,349 - 41,866,844 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX41,823,355 - 41,866,669 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX43,124,049 - 43,167,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X46,591,399 - 46,634,728 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,256,128 - 44,299,460 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,080,963 - 45,125,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,080,963 - 45,124,270 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X45,378,196 - 45,420,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X63,484,553 - 63,533,858 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX42,479,703 - 42,521,299 (-)NCBICelera
Cytogenetic MapXq21NCBI
Prkx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554992,167,252 - 2,211,911 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554992,167,252 - 2,227,510 (-)NCBIChiLan1.0ChiLan1.0
PRKX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X5,247,944 - 5,352,705 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X5,246,143 - 5,356,363 (-)NCBINHGRI_mPanPan1
PanPan1.1X3,548,503 - 3,654,289 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX3,547,985 - 3,654,322 (-)Ensemblpanpan1.1panPan2
Prkx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049531,946,323 - 2,053,408 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366442,406,926 - 2,430,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366442,407,142 - 2,430,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX657,621 - 753,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X657,421 - 753,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X144,027,915 - 144,169,591 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X1,849,302 - 2,005,033 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660563,709,688 - 3,823,000 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248341,691,765 - 1,745,938 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKX
1798 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 1 5 1 6 1 6 9
Low 2 4 17 5 5 6 12 8 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017781   ⟹   ENSCAFP00000016461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX1,945,379 - 1,983,449 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083457   ⟹   ENSCAFP00000056029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX1,945,379 - 1,972,048 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088795   ⟹   ENSCAFP00000049387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX1,945,379 - 2,014,661 (-)Ensembl
RefSeq Acc Id: XM_038449307   ⟹   XP_038305235
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X1,864,516 - 1,938,512 (-)NCBI
RefSeq Acc Id: XM_038449308   ⟹   XP_038305236
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X1,864,516 - 1,898,820 (-)NCBI
RefSeq Acc Id: XM_038464476   ⟹   XP_038320404
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX1,888,783 - 1,962,819 (-)NCBI
RefSeq Acc Id: XM_038464477   ⟹   XP_038320405
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX1,888,783 - 1,923,078 (-)NCBI
RefSeq Acc Id: XM_038522741   ⟹   XP_038378669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X1,856,007 - 1,929,869 (-)NCBI
RefSeq Acc Id: XM_038522742   ⟹   XP_038378670
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X1,856,007 - 1,890,093 (-)NCBI
RefSeq Acc Id: XM_038586737   ⟹   XP_038442665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X1,899,988 - 1,973,995 (-)NCBI
RefSeq Acc Id: XM_038651249   ⟹   XP_038507177
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X1,871,602 - 1,945,594 (-)NCBI
RefSeq Acc Id: XM_038651250   ⟹   XP_038507178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X1,871,602 - 1,905,844 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000049387   ⟸   ENSCAFT00000088795
RefSeq Acc Id: ENSCAFP00000056029   ⟸   ENSCAFT00000083457
RefSeq Acc Id: ENSCAFP00000016461   ⟸   ENSCAFT00000017781
RefSeq Acc Id: XP_038378669   ⟸   XM_038522741
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038378670   ⟸   XM_038522742
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038507177   ⟸   XM_038651249
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038507178   ⟸   XM_038651250
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038305235   ⟸   XM_038449307
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JKD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038305236   ⟸   XM_038449308
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038320404   ⟸   XM_038464476
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JKD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038320405   ⟸   XM_038464477
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038442665   ⟸   XM_038586737
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JKD5 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011187 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010566 UniProtKB/TrEMBL
  ENSCAFG00040012902 UniProtKB/TrEMBL
  ENSCAFG00845024116 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000088795.2 UniProtKB/TrEMBL
  ENSCAFT00000097710.1 UniProtKB/TrEMBL
  ENSCAFT00030019670.1 UniProtKB/TrEMBL
  ENSCAFT00040023916.1 UniProtKB/TrEMBL
  ENSCAFT00845042572.1 UniProtKB/TrEMBL
  ENSCAFT00845042657.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PRKX ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0JKD5 ENTREZGENE
  A0A8C0SFM5_CANLF UniProtKB/TrEMBL
  A0A8I3PGQ3_CANLF UniProtKB/TrEMBL
  A0A8I3Q055_CANLF UniProtKB/TrEMBL
  A0A8P0PLI2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54833 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 PRKX  protein kinase X-linked    protein kinase, X-linked  Symbol and/or name change 5135510 APPROVED