PRSS37 (serine protease 37) - Rat Genome Database

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Gene: PRSS37 (serine protease 37) Canis lupus familiaris
Analyze
Symbol: PRSS37
Name: serine protease 37
RGD ID: 12321843
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); germ cell migration (ortholog); protein maturation (ortholog); ASSOCIATED WITH Hereditary Pancreatitis (ortholog); RASopathy (ortholog); Sengers syndrome (ortholog); FOUND IN acrosomal vesicle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: probable inactive serine protease 37; protease, serine 37
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,379,344 - 7,385,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,379,830 - 7,385,159 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,224,008 - 8,229,814 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,300,896 - 7,306,702 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,300,899 - 7,306,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,254,225 - 7,260,030 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,096,603 - 7,102,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,164,356 - 7,170,162 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRSS37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,379,344 - 7,385,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,379,830 - 7,385,159 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,224,008 - 8,229,814 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,300,896 - 7,306,702 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,300,899 - 7,306,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,254,225 - 7,260,030 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,096,603 - 7,102,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,164,356 - 7,170,162 (+)NCBIUU_Cfam_GSD_1.0
PRSS37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387141,836,278 - 141,841,485 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7141,836,300 - 141,841,487 (-)EnsemblGRCh38hg38GRCh38
GRCh377141,536,078 - 141,541,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,182,555 - 141,187,690 (-)NCBINCBI36Build 36hg18NCBI36
Celera7136,257,527 - 136,262,670 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7135,832,747 - 135,837,890 (-)NCBIHuRef
CHM1_17141,470,427 - 141,475,570 (-)NCBICHM1_1
T2T-CHM13v2.07143,152,100 - 143,157,307 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)NCBI
Prss37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,491,757 - 40,496,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,491,758 - 40,496,442 (-)EnsemblGRCm39 Ensembl
GRCm38640,514,820 - 40,519,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,464,823 - 40,469,507 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,444,431 - 40,449,113 (-)NCBIMGSCv36mm8
Celera640,502,240 - 40,506,924 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
Prss37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,289,678 - 70,301,259 (-)NCBIGRCr8
mRatBN7.2469,322,977 - 69,334,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,322,977 - 69,334,555 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx474,251,277 - 74,262,855 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0470,172,430 - 70,184,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0468,590,926 - 68,602,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0468,337,498 - 68,349,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl468,337,480 - 68,349,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,126,537 - 133,140,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4468,086,470 - 68,101,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1468,362,599 - 68,377,199 (-)NCBI
Celera464,325,342 - 64,336,751 (-)NCBICelera
Cytogenetic Map4q23NCBI
Prss37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,744,044 - 1,747,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,742,104 - 1,747,310 (+)NCBIChiLan1.0ChiLan1.0
PRSS37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26178,624,886 - 178,630,383 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1730,635,141 - 30,640,638 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07133,767,802 - 133,773,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17146,236,906 - 146,242,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,236,906 - 146,242,157 (-)Ensemblpanpan1.1panPan2
Prss37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,537,705 - 13,542,968 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365925,676,944 - 5,680,479 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365925,676,944 - 5,681,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,111,692 - 8,118,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,112,288 - 8,119,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,207,603 - 8,214,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,583,991 - 110,588,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21110,584,109 - 110,588,046 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660727,262,134 - 7,266,660 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476521,837,894 - 21,844,400 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476521,838,292 - 21,844,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRSS37
43 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 22 19 13 3 6 3 5 29 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006238   ⟹   ENSCAFP00000005778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl167,379,830 - 7,385,159 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845054940   ⟹   ENSCAFP00845043205
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl167,300,899 - 7,306,701 (+)Ensembl
RefSeq Acc Id: XM_038497036   ⟹   XP_038352964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1167,254,225 - 7,260,030 (+)NCBI
RefSeq Acc Id: XM_038559375   ⟹   XP_038415303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0167,164,356 - 7,170,162 (+)NCBI
RefSeq Acc Id: XM_038623355   ⟹   XP_038479283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0167,096,603 - 7,102,409 (+)NCBI
RefSeq Acc Id: XM_038689073   ⟹   XP_038545001
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0167,300,896 - 7,306,702 (+)NCBI
RefSeq Acc Id: XM_539877   ⟹   XP_539877
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1167,379,344 - 7,385,160 (+)NCBI
Dog10K_Boxer_Tasha168,224,008 - 8,229,814 (+)NCBI
Sequence:
RefSeq Acc Id: XP_539877   ⟸   XM_539877
- UniProtKB: A0A8C0L6H5 (UniProtKB/TrEMBL),   A0A8C0L4S7 (UniProtKB/TrEMBL),   A0A8C0QPA8 (UniProtKB/TrEMBL),   A0A8I3Q844 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000005778   ⟸   ENSCAFT00000006238
RefSeq Acc Id: XP_038352964   ⟸   XM_038497036
RefSeq Acc Id: XP_038479283   ⟸   XM_038623355
RefSeq Acc Id: XP_038545001   ⟸   XM_038689073
- UniProtKB: A0A8C0L6H5 (UniProtKB/TrEMBL),   A0A8C0L4S7 (UniProtKB/TrEMBL),   A0A8C0QPA8 (UniProtKB/TrEMBL),   A0A8I3Q844 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415303   ⟸   XM_038559375
- UniProtKB: A0A8C0L4S7 (UniProtKB/TrEMBL),   A0A8C0L6H5 (UniProtKB/TrEMBL),   A0A8C0QPA8 (UniProtKB/TrEMBL),   A0A8I3Q844 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845043205   ⟸   ENSCAFT00845054940
Protein Domains
Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003881 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007229 UniProtKB/TrEMBL
  ENSCAFG00040006912 UniProtKB/TrEMBL
  ENSCAFG00845030911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006238.5 UniProtKB/TrEMBL
  ENSCAFT00030013303.1 UniProtKB/TrEMBL
  ENSCAFT00040012847.1 UniProtKB/TrEMBL
  ENSCAFT00845054940 ENTREZGENE
  ENSCAFT00845054940.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
KEGG Report cfa:482761 UniProtKB/TrEMBL
NCBI Gene PRSS37 ENTREZGENE
PANTHER INACTIVE SERINE PROTEASE 37-RELATED UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A8C0L4S7 ENTREZGENE
  A0A8C0L6H5 ENTREZGENE
  A0A8C0QPA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q844 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45068 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-24 PRSS37  serine protease 37    protease, serine 37  Symbol and/or name change 5135510 APPROVED