DNAH12 (dynein axonemal heavy chain 12) - Rat Genome Database

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Gene: DNAH12 (dynein axonemal heavy chain 12) Canis lupus familiaris
Analyze
Symbol: DNAH12
Name: dynein axonemal heavy chain 12
RGD ID: 12317831
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); dynein intermediate chain binding (inferred); INVOLVED IN microtubule-based movement (inferred); ASSOCIATED WITH genetic disease (ortholog); megacolon (ortholog); Pyruvate Dehydrogenase E1-Beta Deficiency (ortholog); FOUND IN axoneme (inferred); cilium (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dynein heavy chain 12, axonemal; dynein heavy chain 12, axonemal-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,899,264 - 33,109,582 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,900,142 - 33,110,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,828,346 - 33,037,215 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,171,720 - 33,382,027 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,172,797 - 33,382,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,627,485 - 32,831,085 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,985,599 - 33,189,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,157,634 - 33,360,612 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axoneme  (IEA)
cilium  (IEA)
cytoplasm  (IEA)
cytoskeleton  (IEA)
dynein complex  (IEA)
microtubule  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DNAH12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,899,264 - 33,109,582 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,900,142 - 33,110,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,828,346 - 33,037,215 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,171,720 - 33,382,027 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,172,797 - 33,382,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,627,485 - 32,831,085 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,985,599 - 33,189,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,157,634 - 33,360,612 (+)NCBIUU_Cfam_GSD_1.0
DNAH12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,293,700 - 57,556,034 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,293,699 - 57,544,344 (-)EnsemblGRCh38hg38GRCh38
GRCh37357,327,728 - 57,530,071 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,302,817 - 57,361,293 (-)NCBINCBI36Build 36hg18NCBI36
Build 34357,406,977 - 57,415,584NCBI
Celera357,293,347 - 57,543,862 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,376,936 - 57,627,630 (-)NCBIHuRef
CHM1_1357,277,865 - 57,480,169 (-)NCBICHM1_1
T2T-CHM13v2.0357,333,985 - 57,596,408 (-)NCBIT2T-CHM13v2.0
Dnah12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,412,709 - 26,614,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,414,429 - 26,613,660 (+)EnsemblGRCm39 Ensembl
GRCm381426,691,554 - 26,892,719 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,693,274 - 26,891,703 (+)EnsemblGRCm38mm10GRCm38
MGSCv371427,512,760 - 27,558,864 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361425,584,088 - 25,718,518 (+)NCBIMGSCv36mm8
Celera1422,935,309 - 23,130,260 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Dnah12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,932,776 - 2,099,391 (+)NCBIGRCr8
mRatBN7.2161,936,354 - 2,092,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,937,817 - 2,092,664 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0162,377,218 - 2,534,130 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,379,480 - 2,534,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,355,464 - 2,509,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,997,847 - 2,153,633 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,028,121 - 2,029,172 (+)NCBI
Celera161,904,410 - 2,060,580 (+)NCBICelera
Cytogenetic Map16p16NCBI
Dnah12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554307,039,070 - 7,272,927 (-)NCBIChiLan1.0ChiLan1.0
DNAH12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,261,620 - 57,524,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,266,514 - 57,529,137 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,226,665 - 57,478,575 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,435,528 - 58,685,061 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,435,528 - 58,683,585 (-)Ensemblpanpan1.1panPan2
Dnah12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,495,402 - 174,755,420 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364737,634,024 - 7,893,943 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAH12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,148,377 - 39,384,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,148,160 - 39,395,266 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21342,997,377 - 43,200,073 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAH12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,613,937 - 18,860,856 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,614,309 - 18,820,007 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041148,008,671 - 148,256,305 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnah12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482121,611 - 305,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DNAH12
2600 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 1 1 4
Below cutoff 5 5 20 5 6 5 6 5 11 6 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014122374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038427425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038503140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038566103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038630250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002616764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005297893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005341087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005408854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000047961   ⟹   ENSCAFP00000038295
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2032,900,142 - 33,110,339 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040145   ⟹   ENSCAFP00845031441
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2033,172,797 - 33,382,029 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040599   ⟹   ENSCAFP00845031779
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2033,172,797 - 33,382,029 (+)Ensembl
RefSeq Acc Id: XM_014122374   ⟹   XP_013977849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12032,899,281 - 33,109,582 (+)NCBI
Dog10K_Boxer_Tasha2032,828,346 - 33,037,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038427422   ⟹   XP_038283350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02033,171,932 - 33,381,937 (+)NCBI
RefSeq Acc Id: XM_038427423   ⟹   XP_038283351
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02033,172,797 - 33,382,027 (+)NCBI
RefSeq Acc Id: XM_038427424   ⟹   XP_038283352
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02033,171,908 - 33,363,163 (+)NCBI
RefSeq Acc Id: XM_038427425   ⟹   XP_038283353
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02033,171,720 - 33,233,784 (+)NCBI
RefSeq Acc Id: XM_038503137   ⟹   XP_038359065
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,627,697 - 32,830,995 (+)NCBI
RefSeq Acc Id: XM_038503138   ⟹   XP_038359066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,628,562 - 32,831,085 (+)NCBI
RefSeq Acc Id: XM_038503139   ⟹   XP_038359067
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,627,673 - 32,812,239 (+)NCBI
RefSeq Acc Id: XM_038503140   ⟹   XP_038359068
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,627,485 - 32,689,391 (+)NCBI
RefSeq Acc Id: XM_038566103   ⟹   XP_038422031
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02033,157,634 - 33,360,612 (+)NCBI
RefSeq Acc Id: XM_038630247   ⟹   XP_038486175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02032,985,809 - 33,189,470 (+)NCBI
RefSeq Acc Id: XM_038630248   ⟹   XP_038486176
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02032,986,674 - 33,189,560 (+)NCBI
RefSeq Acc Id: XM_038630249   ⟹   XP_038486177
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02032,985,785 - 33,170,685 (+)NCBI
RefSeq Acc Id: XM_038630250   ⟹   XP_038486178
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02032,985,599 - 33,047,874 (+)NCBI
RefSeq Acc Id: XR_005297893
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02033,171,931 - 33,381,885 (+)NCBI
RefSeq Acc Id: XR_005341087
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12032,627,696 - 32,830,943 (+)NCBI
RefSeq Acc Id: XR_005408854
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02032,985,808 - 33,189,418 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013977849   ⟸   XM_014122374
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S5Y2 (UniProtKB/TrEMBL),   A0A8P0SSX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000038295   ⟸   ENSCAFT00000047961
RefSeq Acc Id: XP_038359068   ⟸   XM_038503140
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038359067   ⟸   XM_038503139
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038359065   ⟸   XM_038503137
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038359066   ⟸   XM_038503138
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038486178   ⟸   XM_038630250
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038486177   ⟸   XM_038630249
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038486175   ⟸   XM_038630247
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038486176   ⟸   XM_038630248
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038283353   ⟸   XM_038427425
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038283352   ⟸   XM_038427424
- Peptide Label: isoform X2
- UniProtKB: A0A8I3S5Y2 (UniProtKB/TrEMBL),   A0A8P0SSX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038283350   ⟸   XM_038427422
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S5Y2 (UniProtKB/TrEMBL),   A0A8P0SSX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038283351   ⟸   XM_038427423
- Peptide Label: isoform X1
- UniProtKB: A0A8I3S5Y2 (UniProtKB/TrEMBL),   A0A8P0SSX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038422031   ⟸   XM_038566103
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QWL4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845031779   ⟸   ENSCAFT00845040599
RefSeq Acc Id: ENSCAFP00845031441   ⟸   ENSCAFT00845040145
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007873 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845022260 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047961.4 UniProtKB/TrEMBL
  ENSCAFT00845040145 ENTREZGENE
  ENSCAFT00845040145.1 UniProtKB/TrEMBL
  ENSCAFT00845040599 ENTREZGENE
  ENSCAFT00845040599.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2620 UniProtKB/TrEMBL
  1.10.472.130 UniProtKB/TrEMBL
  1.10.8.1220 UniProtKB/TrEMBL
  1.10.8.710 UniProtKB/TrEMBL
  1.10.8.720 UniProtKB/TrEMBL
  1.20.1270.280 UniProtKB/TrEMBL
  1.20.140.100 UniProtKB/TrEMBL
  1.20.58.1120 UniProtKB/TrEMBL
  1.20.920.20 UniProtKB/TrEMBL
  1.20.920.30 UniProtKB/TrEMBL
  3.10.490.20 UniProtKB/TrEMBL
  3.20.180.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  6.10.140.1060 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_6 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  AAA_lid_11_sf UniProtKB/TrEMBL
  DHC_fam UniProtKB/TrEMBL
  DNAH3_AAA_lid_1 UniProtKB/TrEMBL
  Dynein_2_N UniProtKB/TrEMBL
  Dynein_AAA1S UniProtKB/TrEMBL
  Dynein_AAA5_ext UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_C_barrel UniProtKB/TrEMBL
  Dynein_HC_stalk UniProtKB/TrEMBL
  Dynein_heavy_chain_D4_dom UniProtKB/TrEMBL
  Dynein_heavy_D6_P-loop UniProtKB/TrEMBL
  Dynein_heavy_linker UniProtKB/TrEMBL
  Dynein_linker_3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene DNAH12 ENTREZGENE
PANTHER DYNEIN HEAVY CHAIN UniProtKB/TrEMBL
  DYNEIN HEAVY CHAIN UniProtKB/TrEMBL
Pfam AAA_6 UniProtKB/TrEMBL
  AAA_7 UniProtKB/TrEMBL
  AAA_8 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_1 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  DHC_N2 UniProtKB/TrEMBL
  Dynein_AAA_lid UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_heavy UniProtKB/TrEMBL
  PF12777 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0QWL4 ENTREZGENE
  A0A8I3S5Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S695_CANLF UniProtKB/TrEMBL
  A0A8P0SSX3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:81894 ENTREZGENE