MOGS (mannosyl-oligosaccharide glucosidase) - Rat Genome Database

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Gene: MOGS (mannosyl-oligosaccharide glucosidase) Canis lupus familiaris
Analyze
Symbol: MOGS
Name: mannosyl-oligosaccharide glucosidase
RGD ID: 12317801
Description: ENCODES a protein that exhibits Glc3Man9GlcNAc2 oligosaccharide glucosidase activity (inferred); hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN carbohydrate metabolic process (inferred); oligosaccharide metabolic process (inferred); protein N-linked glycosylation (inferred); ASSOCIATED WITH congenital disorder of glycosylation type IIb (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,666,220 - 48,670,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,667,224 - 48,670,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,309,013 - 48,312,735 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,526,369 - 49,530,091 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,522,868 - 49,530,078 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,543,489 - 48,547,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,610,253 - 48,613,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,167,959 - 49,171,681 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MOGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,666,220 - 48,670,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,667,224 - 48,670,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,309,013 - 48,312,735 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,526,369 - 49,530,091 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,522,868 - 49,530,078 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,543,489 - 48,547,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,610,253 - 48,613,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,167,959 - 49,171,681 (+)NCBIUU_Cfam_GSD_1.0
MOGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,461,057 - 74,465,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,461,057 - 74,465,410 (-)EnsemblGRCh38hg38GRCh38
GRCh37274,688,184 - 74,692,509 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,541,692 - 74,546,045 (-)NCBINCBI36Build 36hg18NCBI36
Build 34274,599,850 - 74,604,161NCBI
Celera274,519,373 - 74,523,726 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,424,479 - 74,428,832 (-)NCBIHuRef
CHM1_1274,617,601 - 74,621,954 (-)NCBICHM1_1
T2T-CHM13v2.0274,469,624 - 74,473,950 (-)NCBIT2T-CHM13v2.0
Mogs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,092,477 - 83,095,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,092,477 - 83,095,879 (+)EnsemblGRCm39 Ensembl
GRCm38683,115,506 - 83,118,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,115,496 - 83,118,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,065,500 - 83,068,892 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,081,164 - 83,084,556 (+)NCBIMGSCv36mm8
Celera685,098,207 - 85,101,599 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Mogs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,179,335 - 117,182,738 (+)NCBIGRCr8
mRatBN7.24115,621,623 - 115,625,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,621,623 - 115,625,032 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,098,230 - 121,101,633 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,873,422 - 116,876,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,487,997 - 115,491,399 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,948,328 - 113,951,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,948,514 - 113,951,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,633,399 - 178,636,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,327,609 - 117,331,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,572,089 - 117,575,493 (+)NCBI
Celera4104,615,822 - 104,619,225 (+)NCBICelera
Cytogenetic Map4q34NCBI
Mogs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,290,849 - 11,324,464 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,317,605 - 11,321,192 (+)NCBIChiLan1.0ChiLan1.0
MOGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,923,246 - 51,928,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,925,983 - 51,930,912 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,527,710 - 74,532,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,033,692 - 76,038,561 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,033,692 - 76,038,561 (-)Ensemblpanpan1.1panPan2
Mogs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,049,848 - 10,053,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556684,394 - 688,056 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556684,203 - 688,037 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,578,218 - 68,581,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,578,207 - 68,581,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,840,317 - 71,844,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MOGS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,812,318 - 32,816,358 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,812,065 - 32,820,175 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,354,282 - 79,358,588 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mogs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,040,983 - 29,048,918 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,041,631 - 29,045,407 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MOGS
30 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 1 4 8
Low 5 5 12 6 5 6 6 4 8 8 2 6
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000013448   ⟹   ENSCAFP00000012442
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1748,667,224 - 48,670,646 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000072598   ⟹   ENSCAFP00000045505
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1748,667,224 - 48,669,204 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033934   ⟹   ENSCAFP00845026556
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1749,522,868 - 49,528,447 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033998   ⟹   ENSCAFP00845026606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1749,526,422 - 49,530,078 (+)Ensembl
RefSeq Acc Id: XM_038499095   ⟹   XP_038355023
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11748,543,489 - 48,547,212 (+)NCBI
RefSeq Acc Id: XM_038561683   ⟹   XP_038417611
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01749,167,959 - 49,171,681 (+)NCBI
RefSeq Acc Id: XM_038625724   ⟹   XP_038481652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01748,610,253 - 48,613,972 (+)NCBI
RefSeq Acc Id: XM_038691652   ⟹   XP_038547580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01749,526,369 - 49,530,091 (+)NCBI
RefSeq Acc Id: XM_540220   ⟹   XP_540220
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11748,666,220 - 48,670,848 (+)NCBI
Dog10K_Boxer_Tasha1748,309,013 - 48,312,735 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_540220   ⟸   XM_540220
- UniProtKB: A0A8C0NZ98 (UniProtKB/TrEMBL),   A0A8P0NAL4 (UniProtKB/TrEMBL),   A0A8C0QHU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000012442   ⟸   ENSCAFT00000013448
RefSeq Acc Id: ENSCAFP00000045505   ⟸   ENSCAFT00000072598
RefSeq Acc Id: XP_038355023   ⟸   XM_038499095
RefSeq Acc Id: XP_038481652   ⟸   XM_038625724
RefSeq Acc Id: XP_038547580   ⟸   XM_038691652
- UniProtKB: A0A8C0KNJ1 (UniProtKB/TrEMBL),   A0A8I3P477 (UniProtKB/TrEMBL),   A0A8C0QHU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038417611   ⟸   XM_038561683
- UniProtKB: A0A8C0KNJ1 (UniProtKB/TrEMBL),   A0A8C0QHU4 (UniProtKB/TrEMBL),   A0A8I3P477 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026556   ⟸   ENSCAFT00845033934
RefSeq Acc Id: ENSCAFP00845026606   ⟸   ENSCAFT00845033998
Protein Domains
Glycosyl hydrolase family 63 C-terminal   Glycosyl hydrolase family 63 N-terminal

Promoters
RGD ID:13686310
Promoter ID:EPDNEW_C4377
Type:initiation region
Name:MOGS_1
Description:mannosyl-oligosaccharide glucosidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11748,667,208 - 48,667,268EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008478 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019672 UniProtKB/TrEMBL
  ENSCAFG00040008182 UniProtKB/TrEMBL
  ENSCAFG00845019226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013448.3 UniProtKB/TrEMBL
  ENSCAFT00000072598.2 UniProtKB/TrEMBL
  ENSCAFT00030036286.1 UniProtKB/TrEMBL
  ENSCAFT00040015451.1 UniProtKB/TrEMBL
  ENSCAFT00845033934.1 UniProtKB/TrEMBL
  ENSCAFT00845033998 ENTREZGENE
  ENSCAFT00845033998.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
  2.70.98.110 UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase_sf UniProtKB/TrEMBL
  6hp_glycosidase-like_sf UniProtKB/TrEMBL
  Glyco_hydro_63_C UniProtKB/TrEMBL
  Glyco_hydro_63N UniProtKB/TrEMBL
  Glyco_hydro_63N_sf UniProtKB/TrEMBL
  Glycoside_hydrolase_63 UniProtKB/TrEMBL
KEGG Report cfa:483104 UniProtKB/TrEMBL
NCBI Gene MOGS ENTREZGENE
PANTHER MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE UniProtKB/TrEMBL
  PTHR10412 UniProtKB/TrEMBL
Pfam Glyco_hydro_63 UniProtKB/TrEMBL
  Glyco_hydro_63N UniProtKB/TrEMBL
Superfamily-SCOP SSF48208 UniProtKB/TrEMBL
UniProt A0A8C0KNJ1 ENTREZGENE
  A0A8C0NZ98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QHU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P477 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P9K7_CANLF UniProtKB/TrEMBL
  A0A8P0NAL4 ENTREZGENE
  A0A8P0NVS6_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0NAL4 UniProtKB/TrEMBL
VGNC ID VGNC:43311 ENTREZGENE