PTPN21 (protein tyrosine phosphatase non-receptor type 21) - Rat Genome Database

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Gene: PTPN21 (protein tyrosine phosphatase non-receptor type 21) Canis lupus familiaris
Analyze
Symbol: PTPN21
Name: protein tyrosine phosphatase non-receptor type 21
RGD ID: 12313664
Description: ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); genetic disease (ortholog); Leber congenital amaurosis 3 (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,707,192 - 59,783,185 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha859,285,172 - 59,364,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0859,976,521 - 60,056,056 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,655,290 - 59,735,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,701,218 - 59,780,673 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0860,034,791 - 60,114,624 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPN21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,707,192 - 59,783,185 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha859,285,172 - 59,364,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0859,976,521 - 60,056,056 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,655,290 - 59,735,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,701,218 - 59,780,673 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0860,034,791 - 60,114,624 (-)NCBIUU_Cfam_GSD_1.0
PTPN21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381488,465,778 - 88,555,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1488,465,778 - 88,555,007 (-)EnsemblGRCh38hg38GRCh38
GRCh371488,932,122 - 89,021,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361488,001,875 - 88,090,876 (-)NCBINCBI36Build 36hg18NCBI36
Build 341488,003,869 - 88,090,876NCBI
Celera1468,977,718 - 69,066,716 (-)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1469,102,423 - 69,191,405 (-)NCBIHuRef
CHM1_11488,869,992 - 88,958,966 (-)NCBICHM1_1
T2T-CHM13v2.01482,686,590 - 82,775,829 (-)NCBIT2T-CHM13v2.0
Ptpn21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,643,000 - 98,703,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,643,000 - 98,703,664 (-)EnsemblGRCm39 Ensembl
GRCm381298,676,741 - 98,737,613 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,676,741 - 98,737,405 (-)EnsemblGRCm38mm10GRCm38
MGSCv371299,914,951 - 99,975,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361299,077,792 - 99,135,644 (-)NCBIMGSCv36mm8
Celera1299,901,870 - 99,962,936 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.88NCBI
Ptpn21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,662,783 - 123,727,809 (-)NCBIGRCr8
mRatBN7.26117,933,066 - 117,998,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,933,066 - 117,998,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6118,083,639 - 118,148,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06118,380,435 - 118,445,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,715,307 - 117,780,330 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,656,500 - 122,721,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,656,500 - 122,721,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06131,870,742 - 131,942,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46122,840,062 - 122,910,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16122,843,808 - 122,914,686 (-)NCBI
Celera6115,494,945 - 115,557,718 (-)NCBICelera
Cytogenetic Map6q32NCBI
Ptpn21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543811,090,044 - 11,153,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543811,087,906 - 11,162,592 (-)NCBIChiLan1.0ChiLan1.0
PTPN21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,612,293 - 89,706,427 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,828,800 - 88,917,631 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01469,085,843 - 69,174,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11488,444,261 - 88,528,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1488,444,261 - 88,528,951 (-)Ensemblpanpan1.1panPan2
Ptpn21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,072,021 - 16,147,382 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,923,833 - 15,995,142 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,922,624 - 15,996,997 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7110,373,530 - 110,453,812 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17110,374,915 - 110,453,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,869,832 - 116,952,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12466,102,081 - 66,191,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2466,101,788 - 66,187,987 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605353,464,502 - 53,552,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473413,802,165 - 13,863,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473413,801,739 - 13,866,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPN21
917 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 16 6 6 6 12 8 10 6
Low 1 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027536   ⟹   ENSCAFP00000025608
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062816   ⟹   ENSCAFP00000065063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081639   ⟹   ENSCAFP00000050910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018302   ⟹   ENSCAFP00845014282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018419   ⟹   ENSCAFP00845014381
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845018502   ⟹   ENSCAFP00845014434
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)Ensembl
RefSeq Acc Id: XM_038484006   ⟹   XP_038339934
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1859,655,290 - 59,735,083 (-)NCBI
RefSeq Acc Id: XM_038484007   ⟹   XP_038339935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1859,655,290 - 59,731,629 (-)NCBI
RefSeq Acc Id: XM_038545501   ⟹   XP_038401429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0860,034,791 - 60,114,624 (-)NCBI
RefSeq Acc Id: XM_038545502   ⟹   XP_038401430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0860,034,791 - 60,111,147 (-)NCBI
RefSeq Acc Id: XM_038593568   ⟹   XP_038449496
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha859,285,172 - 59,364,633 (-)NCBI
RefSeq Acc Id: XM_038609593   ⟹   XP_038465521
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0859,701,218 - 59,780,673 (-)NCBI
RefSeq Acc Id: XM_038609594   ⟹   XP_038465522
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0859,701,218 - 59,777,229 (-)NCBI
RefSeq Acc Id: XM_038674411   ⟹   XP_038530339
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0859,976,521 - 60,056,056 (-)NCBI
RefSeq Acc Id: XM_547945   ⟹   XP_547945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1859,707,192 - 59,783,185 (-)NCBI
Dog10K_Boxer_Tasha859,285,172 - 59,361,193 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_547945   ⟸   XM_547945
- UniProtKB: A0A8C0KWH3 (UniProtKB/TrEMBL),   A0A8C0M4C4 (UniProtKB/TrEMBL),   A0A8P0SLM9 (UniProtKB/TrEMBL),   A0A8C0PPG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000025608   ⟸   ENSCAFT00000027536
RefSeq Acc Id: ENSCAFP00000065063   ⟸   ENSCAFT00000062816
RefSeq Acc Id: ENSCAFP00000050910   ⟸   ENSCAFT00000081639
RefSeq Acc Id: XP_038339934   ⟸   XM_038484006
RefSeq Acc Id: XP_038339935   ⟸   XM_038484007
RefSeq Acc Id: XP_038465521   ⟸   XM_038609593
RefSeq Acc Id: XP_038465522   ⟸   XM_038609594
RefSeq Acc Id: XP_038530339   ⟸   XM_038674411
- UniProtKB: A0A8I3NH16 (UniProtKB/TrEMBL),   A0A8C0PPG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038449496   ⟸   XM_038593568
- UniProtKB: A0A8C0KWH3 (UniProtKB/TrEMBL),   A0A8C0M4C4 (UniProtKB/TrEMBL),   A0A8P0SLM9 (UniProtKB/TrEMBL),   A0A8C0PPG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401429   ⟸   XM_038545501
- UniProtKB: A0A8C0KWH3 (UniProtKB/TrEMBL),   A0A8C0M4C4 (UniProtKB/TrEMBL),   A0A8C0PPG9 (UniProtKB/TrEMBL),   A0A8P0SLM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401430   ⟸   XM_038545502
- UniProtKB: A0A8C0KWH3 (UniProtKB/TrEMBL),   A0A8C0M4C4 (UniProtKB/TrEMBL),   A0A8C0PPG9 (UniProtKB/TrEMBL),   A0A8P0SLM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014282   ⟸   ENSCAFT00845018302
RefSeq Acc Id: ENSCAFP00845014434   ⟸   ENSCAFT00845018502
RefSeq Acc Id: ENSCAFP00845014381   ⟸   ENSCAFT00845018419
Protein Domains
FERM   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017377 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002839 UniProtKB/TrEMBL
  ENSCAFG00040001306 UniProtKB/TrEMBL
  ENSCAFG00845010389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027536.6 UniProtKB/TrEMBL
  ENSCAFT00000081639.2 UniProtKB/TrEMBL
  ENSCAFT00030005264.1 UniProtKB/TrEMBL
  ENSCAFT00030005303.1 UniProtKB/TrEMBL
  ENSCAFT00030005329.1 UniProtKB/TrEMBL
  ENSCAFT00040002453.1 UniProtKB/TrEMBL
  ENSCAFT00040002471.1 UniProtKB/TrEMBL
  ENSCAFT00040002497.1 UniProtKB/TrEMBL
  ENSCAFT00845018302 ENTREZGENE
  ENSCAFT00845018302.1 UniProtKB/TrEMBL
  ENSCAFT00845018419.1 UniProtKB/TrEMBL
  ENSCAFT00845018502.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  1.20.80.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_non-rcpt_14/21 UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  PTPN14/21_FERM_C UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene PTPN21 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr14 UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C0KWH3 ENTREZGENE
  A0A8C0M4C4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0M6S2_CANLF UniProtKB/TrEMBL
  A0A8C0PPF3_CANLF UniProtKB/TrEMBL
  A0A8C0PPG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NDI8_CANLF UniProtKB/TrEMBL
  A0A8I3NEW6_CANLF UniProtKB/TrEMBL
  A0A8I3NH16 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SLM9 ENTREZGENE
UniProt Secondary A0A8P0P0P4 UniProtKB/TrEMBL
  A0A8P0SLM9 UniProtKB/TrEMBL
VGNC ID VGNC:45174 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTPN21  protein tyrosine phosphatase non-receptor type 21    protein tyrosine phosphatase, non-receptor type 21  Symbol and/or name change 5135510 APPROVED