BMPR1A (bone morphogenetic protein receptor type 1A) - Rat Genome Database

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Gene: BMPR1A (bone morphogenetic protein receptor type 1A) Canis lupus familiaris
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Symbol: BMPR1A
Name: bone morphogenetic protein receptor type 1A
RGD ID: 12311334
Description: ENCODES a protein that exhibits ATP binding (inferred); BMP binding (inferred); BMP receptor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); atrioventricular valve development (ortholog); BMP signaling pathway (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1 (ortholog); bone development disease (ortholog); breast cancer (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: INFERRED
Also known as: bone morphogenetic protein receptor type-1A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,499,898 - 34,582,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,508,865 - 34,570,053 (+)NCBI
ROS_Cfam_1.0434,801,402 - 34,942,941 (+)NCBI
UMICH_Zoey_3.1434,723,326 - 34,784,614 (+)NCBI
UNSW_CanFamBas_1.0434,892,537 - 34,953,583 (+)NCBI
UU_Cfam_GSD_1.0435,397,828 - 35,459,419 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
atrioventricular node cell development  (IEA)
atrioventricular valve development  (ISO)
BMP signaling pathway  (IBA,ISO)
BMP signaling pathway involved in heart development  (IEA)
cardiac conduction system development  (ISO)
cardiac right ventricle morphogenesis  (IEA)
cartilage development  (ISO)
cell differentiation  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
chondrocyte differentiation  (IEA)
developmental growth  (IEA,ISO)
dorsal aorta morphogenesis  (IEA)
dorsal/ventral axis specification  (IEA,ISO)
dorsal/ventral pattern formation  (IBA,ISO)
ectoderm development  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic morphogenesis  (ISO)
embryonic organ development  (IEA,ISO)
endocardial cushion formation  (IEA,ISO)
endocardial cushion morphogenesis  (ISO)
endoderm development  (ISO)
fibrous ring of heart morphogenesis  (IEA)
heart development  (ISO)
heart formation  (IEA,ISO)
heart morphogenesis  (ISO)
hindlimb morphogenesis  (IEA,ISO)
immune response  (IEA)
in utero embryonic development  (IEA,ISO)
lateral mesoderm development  (IEA,ISO)
lung development  (IEA,ISO)
mesendoderm development  (IEA,ISO)
mesoderm formation  (IEA,ISO)
mitral valve morphogenesis  (IEA)
Mullerian duct regression  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of muscle cell differentiation  (IEA)
negative regulation of neurogenesis  (IEA,ISO)
negative regulation of smooth muscle cell migration  (IEA)
nervous system development  (ISO)
neural crest cell development  (IEA,ISO)
neural plate mediolateral regionalization  (IEA,ISO)
neural plate pattern specification  (ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEA)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA)
paraxial mesoderm development  (ISO)
paraxial mesoderm structural organization  (IEA,ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (IEA)
pituitary gland development  (IEA,ISO)
positive regulation of bone mineralization  (IEA)
positive regulation of cardiac muscle cell proliferation  (IEA)
positive regulation of cardiac ventricle development  (IEA)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta2 production  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
protein phosphorylation  (IBA)
regulation of cardiac muscle cell apoptotic process  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of cellular senescence  (IEA,ISO)
regulation of endothelial cell differentiation  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of lateral mesodermal cell fate specification  (IEA,ISO)
regulation of neural crest cell differentiation  (ISO)
regulation of neural crest cell fate specification  (ISO)
roof of mouth development  (IEA,ISO)
somitogenesis  (IEA,ISO)
stem cell population maintenance  (IEA,ISO)
tricuspid valve morphogenesis  (IEA)
ventricular compact myocardium morphogenesis  (IEA)
ventricular septum morphogenesis  (IEA)
ventricular trabecula myocardium morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
BMPR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,499,898 - 34,582,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,508,865 - 34,570,053 (+)NCBI
ROS_Cfam_1.0434,801,402 - 34,942,941 (+)NCBI
UMICH_Zoey_3.1434,723,326 - 34,784,614 (+)NCBI
UNSW_CanFamBas_1.0434,892,537 - 34,953,583 (+)NCBI
UU_Cfam_GSD_1.0435,397,828 - 35,459,419 (+)NCBI
BMPR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1086,756,601 - 86,932,825 (+)EnsemblGRCh38hg38GRCh38
GRCh381086,755,786 - 86,927,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371088,516,376 - 88,687,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,506,376 - 88,674,925 (+)NCBINCBI36hg18NCBI36
Build 341088,506,375 - 88,674,924NCBI
Celera1082,519,484 - 82,687,979 (+)NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,370,811 - 82,538,774 (+)NCBIHuRef
CHM1_11088,798,078 - 88,966,382 (+)NCBICHM1_1
Bmpr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,133,018 - 34,225,335 (-)NCBIGRCm39mm39
GRCm39 Ensembl1434,132,691 - 34,225,298 (-)Ensembl
GRCm381434,411,061 - 34,503,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,410,734 - 34,503,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371435,224,254 - 35,315,732 (-)NCBIGRCm37mm9NCBIm37
MGSCv361433,240,160 - 33,331,638 (-)NCBImm8
Celera1430,676,409 - 30,725,958 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
Bmpr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2169,736,390 - 9,829,825 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl169,736,630 - 9,780,616 (-)Ensembl
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
Bmpr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBIChiLan1.0ChiLan1.0
BMPR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11086,742,248 - 86,912,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,837,469 - 86,912,912 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01083,185,040 - 83,353,239 (+)NCBIMhudiblu_PPA_v0panPan3
Bmpr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,941,218 - 44,004,913 (-)NCBI
SpeTri2.0NW_00493680452,435 - 115,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,742,459 - 87,891,793 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,743,270 - 87,891,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,239,745 - 95,280,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,944,463 - 45,108,832 (-)NCBI
ChlSab1.1 Ensembl944,941,460 - 45,027,275 (-)Ensembl
Vero_WHO_p1.0NW_0236660485,049,884 - 5,217,543 (-)NCBI
Bmpr1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624841218,642 - 304,744 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 1 6 1 6 5 11 10 6
Low 6 5 5 1 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025524   ⟹   ENSCAFP00000023698
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)Ensembl
RefSeq Acc Id: NM_001145150   ⟹   NP_001138622
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1434,517,536 - 34,578,560 (+)NCBI
Dog10K_Boxer_Tasha434,508,865 - 34,570,053 (+)NCBI
ROS_Cfam_1.0434,877,599 - 34,938,995 (+)NCBI
UMICH_Zoey_3.1434,723,326 - 34,784,614 (+)NCBI
UNSW_CanFamBas_1.0434,892,537 - 34,953,583 (+)NCBI
UU_Cfam_GSD_1.0435,397,828 - 35,459,419 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005618880   ⟹   XP_005618937
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1434,499,898 - 34,582,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038662301   ⟹   XP_038518229
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0434,801,402 - 34,942,941 (+)NCBI
RefSeq Acc Id: XM_038662302   ⟹   XP_038518230
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0434,801,468 - 34,942,941 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001138622 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518229 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518230 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005618937   ⟸   XM_005618880
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001138622   ⟸   NM_001145150
- UniProtKB: E2QW66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023698   ⟸   ENSCAFT00000025524
RefSeq Acc Id: XP_038518229   ⟸   XM_038662301
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038518230   ⟸   XM_038662302
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016077 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000023698 ENTREZGENE
Ensembl Transcript ENSCAFT00000025524 ENTREZGENE
NCBI Gene BMPR1A ENTREZGENE
UniProt E2QW66 ENTREZGENE
VGNC ID VGNC:38484 ENTREZGENE