PLA2G2E (phospholipase A2 group IIE) - Rat Genome Database

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Gene: PLA2G2E (phospholipase A2 group IIE) Canis lupus familiaris
Analyze
Symbol: PLA2G2E
Name: phospholipase A2 group IIE
RGD ID: 12311309
Description: ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent phospholipase A2 activity (inferred); hydrolase activity (inferred); INVOLVED IN low-density lipoprotein particle remodeling (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); chromosome 1p36 deletion syndrome (ortholog); congenital disorder of glycosylation Ir (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: group IIE secretory phospholipase A2; LOC487399; phospholipase A2, group IIE
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,834,820 - 78,838,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,831,309 - 78,841,821 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,348,378 - 75,351,277 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,401,692 - 79,404,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,401,692 - 79,405,786 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,220,563 - 76,223,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,227,501 - 77,230,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,298,456 - 78,301,338 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLA2G2E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,834,820 - 78,838,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,831,309 - 78,841,821 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,348,378 - 75,351,277 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,401,692 - 79,404,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,401,692 - 79,405,786 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,220,563 - 76,223,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,227,501 - 77,230,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,298,456 - 78,301,338 (+)NCBIUU_Cfam_GSD_1.0
PLA2G2E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,920,009 - 19,923,617 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,920,009 - 19,923,617 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,246,502 - 20,250,110 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,119,387 - 20,122,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 34119,992,105 - 19,995,416NCBI
Celera118,573,636 - 18,576,946 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef118,492,424 - 18,495,734 (-)NCBIHuRef
CHM1_1120,356,341 - 20,359,651 (-)NCBICHM1_1
T2T-CHM13v2.0119,743,391 - 19,746,999 (-)NCBIT2T-CHM13v2.0
Pla2g2e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,605,253 - 138,610,125 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,605,253 - 138,610,128 (+)EnsemblGRCm39 Ensembl
GRCm384138,877,911 - 138,882,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,877,942 - 138,882,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,433,857 - 138,438,729 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,150,018 - 138,154,890 (+)NCBIMGSCv36mm8
Celera4140,664,246 - 140,669,119 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.57NCBI
Pla2g2e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,404,639 - 156,410,421 (+)NCBIGRCr8
mRatBN7.25151,121,363 - 151,127,147 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,121,439 - 151,126,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,818,819 - 153,824,204 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,593,127 - 155,598,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,575,036 - 155,580,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,327,657 - 157,333,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,327,657 - 157,333,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,068,641 - 161,074,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,699,794 - 157,705,176 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,694,981 - 157,715,203 (+)NCBI
Celera5149,507,214 - 149,512,594 (+)NCBICelera
Cytogenetic Map5q36NCBI
Pla2g2e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955452520,361 - 525,846 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955452522,314 - 526,095 (-)NCBIChiLan1.0ChiLan1.0
PLA2G2E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,195,771 - 207,202,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,312,620 - 206,316,256 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,874,301 - 18,878,218 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,918,391 - 19,921,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,918,391 - 19,921,639 (-)Ensemblpanpan1.1panPan2
PLA2G2E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,278,284 - 78,282,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,278,080 - 78,282,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLA2G2E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,632,404 - 112,636,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,632,759 - 112,635,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660333,543,895 - 3,548,096 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g2e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,985,688 - 4,988,818 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247644,984,021 - 4,989,315 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G2E
81 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
1 14 6 1 6 2 1 8 6

Sequence


Ensembl Acc Id: ENSCAFT00000023955   ⟹   ENSCAFP00000022239
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl278,831,309 - 78,841,821 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845005509   ⟹   ENSCAFP00845004374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl279,401,692 - 79,405,786 (+)Ensembl
RefSeq Acc Id: XM_038468929   ⟹   XP_038324857
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1276,220,563 - 76,223,447 (+)NCBI
RefSeq Acc Id: XM_038529649   ⟹   XP_038385577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0278,298,456 - 78,301,338 (+)NCBI
RefSeq Acc Id: XM_038593885   ⟹   XP_038449813
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0277,227,501 - 77,230,383 (+)NCBI
RefSeq Acc Id: XM_038657964   ⟹   XP_038513892
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0279,401,692 - 79,404,574 (+)NCBI
RefSeq Acc Id: XM_544525   ⟹   XP_544525
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1278,834,820 - 78,838,058 (+)NCBI
Dog10K_Boxer_Tasha275,348,378 - 75,351,277 (+)NCBI
Sequence:
RefSeq Acc Id: XP_544525   ⟸   XM_544525
- UniProtKB: A0A8P0PGG4 (UniProtKB/TrEMBL),   A0A8C0Q7A4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000022239   ⟸   ENSCAFT00000023955
RefSeq Acc Id: XP_038324857   ⟸   XM_038468929
RefSeq Acc Id: XP_038449813   ⟸   XM_038593885
RefSeq Acc Id: XP_038513892   ⟸   XM_038657964
- UniProtKB: A0A8C0K679 (UniProtKB/TrEMBL),   A0A8C0RES7 (UniProtKB/TrEMBL),   A0A8I3MQ33 (UniProtKB/TrEMBL),   A0A8C0Q7A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038385577   ⟸   XM_038529649
- UniProtKB: A0A8C0K679 (UniProtKB/TrEMBL),   A0A8C0Q7A4 (UniProtKB/TrEMBL),   A0A8C0RES7 (UniProtKB/TrEMBL),   A0A8I3MQ33 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845004374   ⟸   ENSCAFT00845005509
Protein Domains
Phospholipase A2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023233 Ensembl
  ENSCAFG00000059201 UniProtKB/TrEMBL
  ENSCAFG00030007523 UniProtKB/TrEMBL
  ENSCAFG00040005934 UniProtKB/TrEMBL
  ENSCAFG00845003130 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000101317.1 UniProtKB/TrEMBL
  ENSCAFT00030013803.1 UniProtKB/TrEMBL
  ENSCAFT00040011089.1 UniProtKB/TrEMBL
  ENSCAFT00845005509 ENTREZGENE
  ENSCAFT00845005509.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
KEGG Report cfa:487399 UniProtKB/TrEMBL
NCBI Gene LOC487399 ENTREZGENE
PANTHER GROUP IIE SECRETORY PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_HIS UniProtKB/TrEMBL
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A8C0K679 ENTREZGENE
  A0A8C0Q7A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RES7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQ33 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PGG4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:103648 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-11 PLA2G2E  phospholipase A2 group IIE  LOC487399  group IIE secretory phospholipase A2  Symbol and/or name change 19259463 PROVISIONAL