PSMC3 (proteasome 26S subunit, ATPase 3) - Rat Genome Database

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Gene: PSMC3 (proteasome 26S subunit, ATPase 3) Canis lupus familiaris
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Symbol: PSMC3
Name: proteasome 26S subunit, ATPase 3
RGD ID: 12311134
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN blastocyst development (ortholog); modulation by host of viral transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH cataract (ortholog); congenital disorder of glycosylation type IIc (ortholog); DEAFNESS, CATARACT, IMPAIRED INTELLECTUAL DEVELOPMENT, AND POLYNEUROPATHY (ortholog); FOUND IN P-body (ortholog); perinuclear region of cytoplasm (ortholog); proteasome accessory complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 26S protease regulatory subunit 6A; 26S proteasome regulatory subunit 6A; proteasome (prosome, macropain) 26S subunit, ATPase, 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,212,083 - 42,218,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,942,640 - 40,949,498 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,867,799 - 42,874,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,867,947 - 42,874,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,354,412 - 42,361,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,909,294 - 41,916,243 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,638,826 - 42,645,702 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PSMC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,212,083 - 42,218,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,942,640 - 40,949,498 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,867,799 - 42,874,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,867,947 - 42,874,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,354,412 - 42,361,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,909,294 - 41,916,243 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,638,826 - 42,645,702 (+)NCBIUU_Cfam_GSD_1.0
PSMC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,418,775 - 47,426,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,418,769 - 47,426,473 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,440,326 - 47,447,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,396,896 - 47,404,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,396,895 - 47,404,565NCBI
Celera1147,582,015 - 47,589,718 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,139,662 - 47,147,028 (-)NCBIHuRef
CHM1_11147,439,552 - 47,447,251 (-)NCBICHM1_1
T2T-CHM13v2.01147,577,679 - 47,585,336 (-)NCBIT2T-CHM13v2.0
Psmc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,884,361 - 90,889,783 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,884,354 - 90,896,714 (+)EnsemblGRCm39 Ensembl
GRCm38291,054,016 - 91,059,438 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,054,009 - 91,066,369 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,894,173 - 90,899,595 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,854,921 - 90,860,267 (+)NCBIMGSCv36mm8
Celera292,438,480 - 92,443,912 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Psmc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,487,643 - 97,493,025 (+)NCBIGRCr8
mRatBN7.2377,031,825 - 77,037,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,510,318 - 80,515,699 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,109,333 - 89,114,714 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,960,503 - 86,965,883 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,876,938 - 79,882,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,585,691 - 86,591,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,413,567 - 75,418,948 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,309,938 - 75,315,317 (+)NCBI
Celera376,240,531 - 76,245,912 (+)NCBICelera
Cytogenetic Map3q24NCBI
Psmc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422837,573 - 845,341 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422837,934 - 843,161 (+)NCBIChiLan1.0ChiLan1.0
PSMC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,621,734 - 49,629,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,641,522 - 49,649,232 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,366,986 - 47,374,677 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,920,295 - 47,927,654 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,920,295 - 47,927,654 (-)Ensemblpanpan1.1panPan2
Psmc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,699,233 - 19,705,397 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,810,864 - 1,823,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,810,883 - 1,817,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,166,306 - 15,193,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,185,482 - 15,191,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,392,149 - 16,397,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,881,844 - 17,896,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038115,190,816 - 115,198,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,362,132 - 1,372,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,361,970 - 1,367,282 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PSMC3
86 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00845037639   ⟹   ENSCAFP00845029490
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1842,867,947 - 42,874,677 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845037723   ⟹   ENSCAFP00845029558
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1842,867,947 - 42,874,677 (+)Ensembl
RefSeq Acc Id: XM_038424370   ⟹   XP_038280298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01842,867,799 - 42,874,682 (+)NCBI
RefSeq Acc Id: XM_038500711   ⟹   XP_038356639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11842,354,412 - 42,361,285 (+)NCBI
RefSeq Acc Id: XM_038563302   ⟹   XP_038419230
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01842,638,826 - 42,645,702 (+)NCBI
RefSeq Acc Id: XM_038627424   ⟹   XP_038483352
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01841,909,294 - 41,916,243 (+)NCBI
RefSeq Acc Id: XM_533187   ⟹   XP_533187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11842,212,083 - 42,218,958 (+)NCBI
Dog10K_Boxer_Tasha1840,942,640 - 40,949,498 (+)NCBI
Sequence:
RefSeq Acc Id: XP_533187   ⟸   XM_533187
- UniProtKB: A0A8C0MGW5 (UniProtKB/TrEMBL),   A0A8I3PF55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038356639   ⟸   XM_038500711
RefSeq Acc Id: XP_038483352   ⟸   XM_038627424
RefSeq Acc Id: XP_038280298   ⟸   XM_038424370
- UniProtKB: A0A8C0MGW5 (UniProtKB/TrEMBL),   A0A8I3PF55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419230   ⟸   XM_038563302
- UniProtKB: A0A8C0MGW5 (UniProtKB/TrEMBL),   A0A8I3PF55 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845029490   ⟸   ENSCAFT00845037639
RefSeq Acc Id: ENSCAFP00845029558   ⟸   ENSCAFT00845037723
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008701 UniProtKB/TrEMBL
  ENSCAFG00030004159 UniProtKB/TrEMBL
  ENSCAFG00040008238 UniProtKB/TrEMBL
  ENSCAFG00845021252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013842.5 UniProtKB/TrEMBL
  ENSCAFT00030007859.1 UniProtKB/TrEMBL
  ENSCAFT00040015588.1 UniProtKB/TrEMBL
  ENSCAFT00845037639 ENTREZGENE
  ENSCAFT00845037639.1 UniProtKB/TrEMBL
  ENSCAFT00845037723.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_ATP_ID_OB_C UniProtKB/TrEMBL
NCBI Gene PSMC3 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/TrEMBL
  26S PROTEASOME REGULATORY SUBUNIT 6A UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
PROSITE AAA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0MGW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PF55 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PGM5_CANLF UniProtKB/TrEMBL