WASHC1 (WASH complex subunit 1) - Rat Genome Database

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Gene: WASHC1 (WASH complex subunit 1) Canis lupus familiaris
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Symbol: WASHC1
Name: WASH complex subunit 1
RGD ID: 12310247
Description: ENCODES a protein that exhibits phosphatidylinositol 3-kinase inhibitor activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); dendritic cell antigen processing and presentation (ortholog); early endosome to late endosome transport (ortholog); PARTICIPATES IN retromer-mediated pathway; ASSOCIATED WITH chromosome 9p deletion syndrome (ortholog); schizophrenia (ortholog); FOUND IN autophagosome (ortholog); BLOC-1 complex (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC486746; WAS protein family homolog 1; WASH1
RGD Orthologs
Human
Mouse
Rat
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,102,694 - 42,118,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,099,886 - 42,116,339 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,564,689 - 4,581,124 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02742,461,263 - 42,477,702 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,461,240 - 42,477,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,402,542 - 42,419,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,372,199 - 42,388,638 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,924,862 - 3,941,306 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WASHC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,102,694 - 42,118,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,099,886 - 42,116,339 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,564,689 - 4,581,124 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02742,461,263 - 42,477,702 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,461,240 - 42,477,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,402,542 - 42,419,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,372,199 - 42,388,638 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,924,862 - 3,941,306 (+)NCBIUU_Cfam_GSD_1.0
WASHC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38914,513 - 30,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl914,475 - 73,865 (-)EnsemblGRCh38hg38GRCh38
GRCh37914,513 - 29,739 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y57,764,816 - 57,767,433 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map9p24.3NCBI
CHM1_1914,312 - 29,934 (-)NCBICHM1_1
T2T-CHM13v2.098,314 - 23,877 (-)NCBIT2T-CHM13v2.0
Washc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,418,524 - 66,427,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,418,540 - 66,427,498 (+)EnsemblGRCm39 Ensembl
GRCm381766,111,529 - 66,120,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1766,111,545 - 66,120,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371766,460,886 - 66,469,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361766,011,089 - 66,020,046 (+)NCBIMGSCv36mm8
Celera1770,419,820 - 70,428,779 (+)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1735.26NCBI
Washc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89113,169,730 - 113,179,829 (+)NCBIGRCr8
mRatBN7.29105,722,779 - 105,830,836 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,722,899 - 105,733,009 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9114,131,463 - 114,141,570 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,241,477 - 119,251,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,597,316 - 117,607,423 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,918,914 - 113,936,861 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,918,858 - 113,936,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09113,443,351 - 113,459,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49104,885,755 - 104,896,516 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19105,095,204 - 105,105,650 (+)NCBI
Celera9103,300,490 - 103,302,995 (-)NCBICelera
Cytogenetic Map9q37NCBI
Washc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945108,955,066 - 108,974,812 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936606209,289 - 228,986 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASHC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl567,394,875 - 67,412,431 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1567,395,737 - 67,412,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2569,630,618 - 69,644,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WASHC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,075 - 27,633 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,116 - 22,842 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660638,319,471 - 8,337,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Washc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624828249,994 - 269,347 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WASHC1
114 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000024933   ⟹   ENSCAFP00000023134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2742,102,713 - 42,116,339 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000078699   ⟹   ENSCAFP00000045959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2742,099,886 - 42,116,339 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845046865   ⟹   ENSCAFP00845036755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2742,461,240 - 42,477,688 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845046937   ⟹   ENSCAFP00845036821
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2742,461,265 - 42,477,376 (-)Ensembl
RefSeq Acc Id: XM_038439355   ⟹   XP_038295283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02742,461,263 - 42,477,702 (-)NCBI
RefSeq Acc Id: XM_038459664   ⟹   XP_038315592
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha274,564,689 - 4,581,124 (+)NCBI
RefSeq Acc Id: XM_038514015   ⟹   XP_038369943
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12742,402,542 - 42,419,383 (-)NCBI
RefSeq Acc Id: XM_038576431   ⟹   XP_038432359
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0273,924,862 - 3,941,306 (+)NCBI
RefSeq Acc Id: XM_038641864   ⟹   XP_038497792
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02742,372,199 - 42,388,638 (-)NCBI
Ensembl Acc Id: ENSCAFP00000045959   ⟸   ENSCAFT00000078699
Ensembl Acc Id: ENSCAFP00000023134   ⟸   ENSCAFT00000024933
RefSeq Acc Id: XP_038369943   ⟸   XM_038514015
RefSeq Acc Id: XP_038497792   ⟸   XM_038641864
RefSeq Acc Id: XP_038295283   ⟸   XM_038439355
- UniProtKB: A0A8I3PQ08 (UniProtKB/TrEMBL),   A0A8P0NH26 (UniProtKB/TrEMBL),   A0A8C0PHX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315592   ⟸   XM_038459664
- UniProtKB: A0A8I3PQ08 (UniProtKB/TrEMBL),   A0A8P0NH26 (UniProtKB/TrEMBL),   A0A8C0PHX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432359   ⟸   XM_038576431
- UniProtKB: A0A8C0PHX7 (UniProtKB/TrEMBL),   A0A8I3PQ08 (UniProtKB/TrEMBL),   A0A8P0NH26 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845036821   ⟸   ENSCAFT00845046937
Ensembl Acc Id: ENSCAFP00845036755   ⟸   ENSCAFT00845046865
Protein Domains
WH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015743 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030026001 UniProtKB/TrEMBL
  ENSCAFG00845026599 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024933.5 UniProtKB/TrEMBL
  ENSCAFT00030048047.1 UniProtKB/TrEMBL
  ENSCAFT00845046865.1 UniProtKB/TrEMBL
  ENSCAFT00845046937 ENTREZGENE
  ENSCAFT00845046937.1 UniProtKB/TrEMBL
InterPro WASH1 UniProtKB/TrEMBL
  WASH1_WAHD UniProtKB/TrEMBL
  WH2_dom UniProtKB/TrEMBL
NCBI Gene LOC486746 ENTREZGENE
PANTHER PTHR23331 UniProtKB/TrEMBL
  WAS PROTEIN FAMILY HOMOLOG 2-RELATED UniProtKB/TrEMBL
Pfam WASH_WAHD UniProtKB/TrEMBL
PROSITE WH2 UniProtKB/TrEMBL
UniProt A0A8C0PHX7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PQ08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PYM9_CANLF UniProtKB/TrEMBL
  A0A8P0NH26 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 WASHC1  WASH complex subunit 1  LOC486746  WAS protein family homolog 1  Symbol and/or name change 5135510 APPROVED