ABCG8 (ATP binding cassette subfamily G member 8) - Rat Genome Database

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Gene: ABCG8 (ATP binding cassette subfamily G member 8) Canis lupus familiaris
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Symbol: ABCG8
Name: ATP binding cassette subfamily G member 8
RGD ID: 12306322
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); cholesterol transfer activity (ortholog); INVOLVED IN bile acid signaling pathway (ortholog); cholesterol homeostasis (ortholog); phospholipid transport (ortholog); PARTICIPATES IN bile acid signaling pathway; ASSOCIATED WITH arteriosclerosis (ortholog); cholestasis (ortholog); congenital hemolytic anemia (ortholog); FOUND IN apical plasma membrane (inferred); ATP-binding cassette (ABC) transporter complex (inferred); integral component of membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,300,142 - 46,319,592 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,300,165 - 46,319,229 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,161,869 - 46,181,385 (+)NCBI
ROS_Cfam_1.01047,178,745 - 47,198,241 (+)NCBI
ROS_Cfam_1.0 Ensembl1047,178,832 - 47,197,878 (+)Ensembl
UMICH_Zoey_3.11046,887,146 - 46,906,668 (+)NCBI
UNSW_CanFamBas_1.01047,176,806 - 47,196,259 (+)NCBI
UU_Cfam_GSD_1.01047,360,439 - 47,379,994 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
ABCG8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,300,142 - 46,319,592 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,300,165 - 46,319,229 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,161,869 - 46,181,385 (+)NCBI
ROS_Cfam_1.01047,178,745 - 47,198,241 (+)NCBI
ROS_Cfam_1.0 Ensembl1047,178,832 - 47,197,878 (+)Ensembl
UMICH_Zoey_3.11046,887,146 - 46,906,668 (+)NCBI
UNSW_CanFamBas_1.01047,176,806 - 47,196,259 (+)NCBI
UU_Cfam_GSD_1.01047,360,439 - 47,379,994 (+)NCBI
ABCG8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38243,838,971 - 43,882,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl243,831,942 - 43,882,988 (+)EnsemblGRCh38hg38GRCh38
GRCh37244,066,110 - 44,110,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,919,607 - 43,959,109 (+)NCBINCBI36hg18NCBI36
Build 34243,977,753 - 44,017,255NCBI
Celera243,904,835 - 43,944,326 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef243,802,799 - 43,841,930 (+)NCBIHuRef
CHM1_1243,995,502 - 44,035,021 (+)NCBICHM1_1
T2T-CHM13v2.0243,844,302 - 43,888,321 (+)NCBI
Abcg8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,983,730 - 85,007,761 (+)NCBIGRCm39mm39
GRCm39 Ensembl1784,983,730 - 85,007,761 (+)Ensembl
GRCm381784,676,302 - 84,700,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,676,302 - 84,700,333 (+)EnsemblGRCm38mm10GRCm38
MGSCv371785,082,471 - 85,099,673 (+)NCBIGRCm37mm9NCBIm37
MGSCv361784,591,457 - 84,608,659 (+)NCBImm8
Celera1789,050,583 - 89,068,069 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
Abcg8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,945,629 - 9,964,912 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl69,945,629 - 9,964,912 (-)Ensembl
Rnor_6.067,961,413 - 7,980,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,961,413 - 7,980,708 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.067,897,005 - 7,916,593 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,064,631 - 8,083,271 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,064,630 - 8,083,271 (+)NCBI
Celera69,667,270 - 9,686,500 (-)NCBICelera
Cytogenetic Map6q12NCBI
Abcg8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,982,307 - 11,009,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,982,307 - 11,004,789 (+)NCBIChiLan1.0ChiLan1.0
ABCG8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A44,771,247 - 44,905,375 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,771,247 - 44,904,830 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A43,922,787 - 43,966,678 (+)NCBIMhudiblu_PPA_v0panPan3
Abcg8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,645,685 - 36,664,967 (-)NCBI
SpeTri2.0NW_0049365088,074,697 - 8,093,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCG8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,596,531 - 96,616,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,596,975 - 96,616,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,751,981 - 102,768,385 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,389,817 - 63,420,048 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,390,433 - 63,413,906 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604548,472,611 - 48,497,995 (+)NCBIVero_WHO_p1.0
Abcg8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,310,917 - 25,329,595 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473825,310,740 - 25,330,097 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 5 8
Low 1 1 1
Below cutoff 4 4 11 5 6 4 11 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003971   ⟹   ENSCAFP00000003668
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1046,300,165 - 46,319,229 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088829   ⟹   ENSCAFP00000056452
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1046,310,470 - 46,319,229 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845045765   ⟹   ENSCAFP00845035919
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1047,178,832 - 47,197,878 (+)Ensembl
RefSeq Acc Id: XM_038489160   ⟹   XP_038345088
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11046,887,146 - 46,906,668 (+)NCBI
RefSeq Acc Id: XM_038551160   ⟹   XP_038407088
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01047,360,439 - 47,379,994 (+)NCBI
RefSeq Acc Id: XM_038615063   ⟹   XP_038470991
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01047,176,806 - 47,196,259 (+)NCBI
RefSeq Acc Id: XM_038680447   ⟹   XP_038536375
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01047,178,745 - 47,198,241 (+)NCBI
RefSeq Acc Id: XM_531799   ⟹   XP_531799
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11046,300,142 - 46,319,592 (+)NCBI
Dog10K_Boxer_Tasha1046,161,869 - 46,181,385 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038345088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038407088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038470991 (Get FASTA)   NCBI Sequence Viewer  
  XP_038536375 (Get FASTA)   NCBI Sequence Viewer  
  XP_531799 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_531799   ⟸   XM_531799
- UniProtKB: F1PS83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000056452   ⟸   ENSCAFT00000088829
RefSeq Acc Id: ENSCAFP00000003668   ⟸   ENSCAFT00000003971
RefSeq Acc Id: XP_038345088   ⟸   XM_038489160
RefSeq Acc Id: XP_038470991   ⟸   XM_038615063
RefSeq Acc Id: XP_038536375   ⟸   XM_038680447
RefSeq Acc Id: XP_038407088   ⟸   XM_038551160
RefSeq Acc Id: ENSCAFP00845035919   ⟸   ENSCAFT00845045765
Protein Domains
ABC transporter

Promoters
RGD ID:13685051
Promoter ID:EPDNEW_C3118
Type:initiation region
Name:ABCG8_1
Description:ATP binding cassette subfamily G member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11046,300,079 - 46,300,139EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
10 46310929 46310930 G A snv Portuguese Wolf (SRS661492)
10 46314548 46314549 C T snv Eurasier (EU035), Kunming Dog (KM10), Mixed Breed (MI016), Kunming Dog (KM9), Leonberger (LB111), Leonberger (LB1919), Malinois (MA094), Eurasier (EU008), Kunming Dog (KM8)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002518 Ensembl
  ENSCAFG00030013872 UniProtKB/TrEMBL
  ENSCAFG00845025922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030022446.1 UniProtKB/TrEMBL
  ENSCAFP00845035919 ENTREZGENE
  ENSCAFP00845035919.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030025706.1 UniProtKB/TrEMBL
  ENSCAFT00845045765 ENTREZGENE
  ENSCAFT00845045765.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ABC_2_trans UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCG_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene ABCG8 ENTREZGENE
Pfam ABC2_membrane UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0N9U1_CANLF UniProtKB/TrEMBL
  A0A8I3PWN5_CANLF UniProtKB/TrEMBL
  F1PS83 ENTREZGENE
VGNC ID VGNC:37455 ENTREZGENE