DHX58 (DExH-box helicase 58) - Rat Genome Database

Name: DHX58
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: DHX58 (DExH-box helicase 58) Canis lupus familiaris

Analyze

Symbol:

DHX58

Name:

DExH-box helicase 58

RGD ID:

12305506

Description:

ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); DNA binding (inferred); INVOLVED IN response to bacterium (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

probable ATP-dependent RNA helicase DHX58

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DHX58 (DExH-box helicase 58)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dhx58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Dhx58 (DEXH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dhx58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DHX58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dhx58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DHX58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DHX58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dhx58 (DExH-box helicase 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,787,470 - 20,795,593 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,787,541 - 20,795,361 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	20,248,380 - 20,256,796 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	21,506,211 - 21,514,628 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	21,506,251 - 21,514,678 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	20,291,486 - 20,299,903 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,558,608 - 20,567,025 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,661,655 - 20,670,075 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (IEA)

cytoplasmic pattern recognition receptor signaling pathway (IEA)

innate immune response (IEA)

negative regulation of innate immune response (IEA)

negative regulation of MDA-5 signaling pathway (IEA)

negative regulation of RIG-I signaling pathway (IEA)

negative regulation of type I interferon production (IEA)

positive regulation of MDA-5 signaling pathway (IEA)

positive regulation of RIG-I signaling pathway (IEA)

positive regulation of type I interferon production (IEA)

regulation of innate immune response (IEA)

response to bacterium (IEA,ISO)

response to virus (IEA)

Cellular Component

cytoplasm (IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

DNA binding (IEA)

double-stranded RNA binding (IEA)

helicase activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

RNA binding (IEA)

RNA helicase activity (IEA)

single-stranded RNA binding (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DHX58
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,787,470 - 20,795,593 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,787,541 - 20,795,361 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	20,248,380 - 20,256,796 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	21,506,211 - 21,514,628 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	21,506,251 - 21,514,678 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	20,291,486 - 20,299,903 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,558,608 - 20,567,025 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,661,655 - 20,670,075 (+)	NCBI		UU_Cfam_GSD_1.0

DHX58
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,101,411 - 42,112,714 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,101,404 - 42,112,714 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	40,253,429 - 40,264,732 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	37,506,948 - 37,518,277 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	36,908,460 - 36,919,789 (-)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	36,018,500 - 36,029,831 (-)	NCBI		HuRef
CHM1_1	17	40,489,197 - 40,500,526 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	42,957,915 - 42,969,232 (-)	NCBI		T2T-CHM13v2.0

Dhx58
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	100,585,710 - 100,595,165 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	100,585,710 - 100,595,097 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	100,694,884 - 100,704,271 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	100,694,884 - 100,704,271 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	100,556,198 - 100,565,585 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	100,510,974 - 100,520,361 (-)	NCBI		MGSCv36	mm8
Celera	11	111,311,383 - 111,320,770 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	63.52	NCBI

Dhx58
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,120,677 - 86,132,095 (-)	NCBI		GRCr8
mRatBN7.2	10	85,620,352 - 85,631,776 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	85,620,357 - 85,631,525 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	90,656,819 - 90,667,976 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,135,311 - 90,146,556 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	85,528,601 - 85,539,768 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	88,599,722 - 88,611,562 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	88,599,680 - 88,611,105 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,393,935 - 88,405,328 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	89,630,145 - 89,641,311 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	89,644,843 - 89,655,680 (-)	NCBI
Celera	10	84,336,054 - 84,347,209 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Dhx58
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,185,510 - 16,191,719 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	16,186,263 - 16,191,928 (-)	NCBI	ChiLan1.0	ChiLan1.0

DHX58
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	22,871,281 - 22,882,643 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	24,761,402 - 24,772,741 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	15,203,216 - 15,214,559 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	15,424,444 - 15,435,588 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	15,424,437 - 15,435,582 (+)	Ensembl	panpan1.1		panPan2

Dhx58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	20,125,092 - 20,134,409 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	16,940,540 - 16,950,085 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	16,940,776 - 16,949,836 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DHX58
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	20,647,699 - 20,656,683 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	20,647,698 - 20,656,691 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	20,937,850 - 20,946,843 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DHX58
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	64,154,832 - 64,166,480 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	64,154,984 - 64,166,500 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,971,770 - 34,983,754 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dhx58
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	1,787,958 - 1,794,692 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	1,787,958 - 1,793,475 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in DHX58
87 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			11		2		2		5		9
Low	5	5	11	6	4	6	4	2	7		1	6
Below cutoff								4		8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014116565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014116566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038485548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038485549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038485550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038547305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038547306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038547307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038602926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038611275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038611276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038611277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038676483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038676484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038676485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001316861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005330635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005330636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005394792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005394795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005398796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005398797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005432128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005432129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000024900 ⟹ ENSCAFP00000023103

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	20,787,541 - 20,795,361 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845018265 ⟹ ENSCAFP00845014250

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	21,506,251 - 21,514,678 (+)	Ensembl

RefSeq Acc Id:

XM_014116565 ⟹ XP_013972040

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	20,787,470 - 20,795,593 (+)	NCBI
Dog10K_Boxer_Tasha	9	20,248,380 - 20,256,796 (+)	NCBI

Sequence:

show sequence

GATTAAGGAGGAATTCTGCCGGTGCTGGCTCCTCCCTCAGTTTCAGTTTCTGTTTCTCGGCATA
GCCCCAGCCCGGTAACACCAGGCACCAGGGCTAAGCTGAGCGGCCACCCTCAGCACCTCAGTGC
CTCAGCACCTAGGCAGGTGTTGCAGATAAGAACCCACGGGGCAAAGATGTGTTGGGGAAGTCTC
TGAACCAGACTGGGCCGGCCAGGAGTCTGACTCTCTTTCCATTGTCAGAATGGAGCTGCGACCC
TACCAGTGGGAGGTGATCATGCCTGCCCTGGAGGGCAAGAATATCATCGTGTGGCTGCCCACTG
GAGCTGGGAAAACCCGGGCTGCTGCTTATGTGGCCAAGAGGCATCTAGAGACTGTGGACCAAGC
CAAGGTGGTTGTACTGGTCAACAGGGTGCACCTGGTGACCCAGCATTGTGAGGAGTTCAGCCGC
ATGCTGGGCAAACGCTGGGCCATTATAACCCTGAGTGGGGACATGGGGCCACGAGCTGGCTTTG
GCCACCTGGCCAGGAGCCATGACCTGATCATCTGCACAGCTGAGCTGCTACAGATGGCGCTGAC
CAGCCCGGAGGAGGAGGAGCACGTGGAGCTCAATGCCTTCTCCCTGCTCGTGGTGGATGAGTGT
CACCACACGCACAAAGACACTGTCTACAACCTCATCCTGAGCCGGTACCTAGAGCATAAACTCC
AGAGGACACGGCCGCTGCCCCAGGTGCTGGGTCTCACAGCCTCCCCGGGCACTGGCGGGGCCTC
CACGCTCGATGGAGCAATTGACCACATCCTACAGCTCTGTGCCAACCTGGACACGTGGCACATC
ATGTCACCGGAGAACCATCGCCCCCAGCTGCAGGAACACAGTGCTCAGCCATGCAAACAGTACA
GTCTCTGCCATAGGCGCAGCCAGGACCCATTTGGGGACATGCTGAAGAAGCTCATGGACCGAAT
CCACAACCGCCTGGAGATGCCCGCGTTAAACCGCGACTTTGGGACACAGACTTATGAGCAGCAG
GTGGTGGAGCTGAGCCAGGATGCGGCCCAGGCCGGACTCCAGCAGCGCCGGGTATACGCTCTTC
ACCTGCGGCGCTACAATGATGCGCTGCTCATCCACGACACGGTCCGCGCTGTGGACGCCCTGAA
GTCGCTGGGAGATTTCTACGACAGGGAGCGCGCCACGAAGACCCAGGTCCTGCAGGCTGAGCGC
TGGCTGCTGGCACTGTTCGATGATTACAAGAATGAGCTGGCCCACCTGGCAACACAGACCCCAG
AGAACCCAAAACTGGAGATGCTAGAACAGATCCTGCGGGAGCAGTTTGGGCATTCCGACAGCCC
CAGGGGCATCATCTTCACCCAGACCCGCCAGAGCACTCACTCCCTCCTACTCTGGCTCCAGCAG
CAGCCAGGCCTGCAGACAGTGGACATTAGGGCTGACCTGCTGATTGGGGCTGGAAATAGTAGCC
AAAACACCCATATGACCCAGAGAGACCAGCAAGAAGTGATCCGAAAGTTCCGGGTTGGCACTCT
GAACCTCCTGGTGGCCACAAGTGTGGCAGAAGAGGGGCTGGACATCCCCCAGTGCAATGTGGTG
GTACGTTACGGGCTCCTGTCCAACGAGATCTCCATGGTCCAGGCAAGGGGCCGGGCCCGGGCTG
GTCGGAGCATATACTCATTTGTGGCAACCCAAGGCAGTCGGGAGCTACGACGGGAGCTGATAAA
CGAGGTGCTGGAGACTTTGATGGAGCGGGCCGTGGCTGCTGTGCAGAAGATGGACCAGGCTGAG
TACCAGGCCAAGATCCGAGATCTGCAGCAGGCAGCCCTGGTCAAGAGGGCAGTCCAGGCAGCCC
AGCGGGACAACCAGCGGCAGCAGTTCCTGGCCGAGCAGGTGCAGCTCCTCTGTGTCAACTGCAT
GGTGGCTGTGGGCCACGGGAGTGACCTGCGGAAGGTGGAGGGCGCTCACCACGTCAATGTGAAC
CCCAACTTCTCGATCTACTACAATGTCTCCCGGGGGCCGGTGGTCATTGACAGAACCTTCAAGG
ACTGGAGGCCTGGGGGTACCATTCACTGCAGGAACTGTGGGGAGGCCTGGGGCCTGCAGATGAT
CTACAAGTCAGTGAAGCTGCCGGCACTCAAAGTCCGCAGCATGCTTCTAGAGACACCCCGAGGG
AGAGTCCAGGCCAAGAAGTGGTCCCGTGTGCCCTTCCCCGTGCCTGACTTCGACTACCTGCAGC
ACTGTGCCCAGAACCTGGCGGACCTCTCCCTGGACTGAGCACCTCATCACTGCAGTGCCCACCT
CAGGCTGCAGGGGGCGGGACAATCCACAGCAGCCACCACCTTGGGGGGGGGGGCCAAGTCCCTC
CTGCCTGAGTCACCAGTTGGGGCACCATGCTGACCAGCCACAGAGGAAACCAGGGCGTCCAGGC
TGGCTCAGACTGTCATGCTGCGGAAGCACCTCTGAGGGCCACAGCTTAGCCCCAGAGCTCCCCT
CATACCACAGACAT

hide sequence

RefSeq Acc Id:

XM_014116566 ⟹ XP_013972041

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	20,787,470 - 20,795,593 (+)	NCBI
Dog10K_Boxer_Tasha	9	20,248,383 - 20,256,796 (+)	NCBI

Sequence:

show sequence

GATTAAGGAGGAATTCTGCCGGTGCTGGCTCCTCCCTCAGTTTCAGTTTCTGTTTCTCGGCATA
GCCCCAGCCCGGTAACACCAGGCACCAGGGCTAAGCTGAGCGGCCACCCTCAGCACCTCAGTGC
CTCAGCACCTAGGCAGGTGTTGCAGATAAGAACCCACGGGGCAAAGAATGGAGCTGCGACCCTA
CCAGTGGGAGGTGATCATGCCTGCCCTGGAGGGCAAGAATATCATCGTGTGGCTGCCCACTGGA
GCTGGGAAAACCCGGGCTGCTGCTTATGTGGCCAAGAGGCATCTAGAGACTGTGGACCAAGCCA
AGGTGGTTGTACTGGTCAACAGGGTGCACCTGGTGACCCAGCATTGTGAGGAGTTCAGCCGCAT
GCTGGGCAAACGCTGGGCCATTATAACCCTGAGTGGGGACATGGGGCCACGAGCTGGCTTTGGC
CACCTGGCCAGGAGCCATGACCTGATCATCTGCACAGCTGAGCTGCTACAGATGGCGCTGACCA
GCCCGGAGGAGGAGGAGCACGTGGAGCTCAATGCCTTCTCCCTGCTCGTGGTGGATGAGTGTCA
CCACACGCACAAAGACACTGTCTACAACCTCATCCTGAGCCGGTACCTAGAGCATAAACTCCAG
AGGACACGGCCGCTGCCCCAGGTGCTGGGTCTCACAGCCTCCCCGGGCACTGGCGGGGCCTCCA
CGCTCGATGGAGCAATTGACCACATCCTACAGCTCTGTGCCAACCTGGACACGTGGCACATCAT
GTCACCGGAGAACCATCGCCCCCAGCTGCAGGAACACAGTGCTCAGCCATGCAAACAGTACAGT
CTCTGCCATAGGCGCAGCCAGGACCCATTTGGGGACATGCTGAAGAAGCTCATGGACCGAATCC
ACAACCGCCTGGAGATGCCCGCGTTAAACCGCGACTTTGGGACACAGACTTATGAGCAGCAGGT
GGTGGAGCTGAGCCAGGATGCGGCCCAGGCCGGACTCCAGCAGCGCCGGGTATACGCTCTTCAC
CTGCGGCGCTACAATGATGCGCTGCTCATCCACGACACGGTCCGCGCTGTGGACGCCCTGAAGT
CGCTGGGAGATTTCTACGACAGGGAGCGCGCCACGAAGACCCAGGTCCTGCAGGCTGAGCGCTG
GCTGCTGGCACTGTTCGATGATTACAAGAATGAGCTGGCCCACCTGGCAACACAGACCCCAGAG
AACCCAAAACTGGAGATGCTAGAACAGATCCTGCGGGAGCAGTTTGGGCATTCCGACAGCCCCA
GGGGCATCATCTTCACCCAGACCCGCCAGAGCACTCACTCCCTCCTACTCTGGCTCCAGCAGCA
GCCAGGCCTGCAGACAGTGGACATTAGGGCTGACCTGCTGATTGGGGCTGGAAATAGTAGCCAA
AACACCCATATGACCCAGAGAGACCAGCAAGAAGTGATCCGAAAGTTCCGGGTTGGCACTCTGA
ACCTCCTGGTGGCCACAAGTGTGGCAGAAGAGGGGCTGGACATCCCCCAGTGCAATGTGGTGGT
ACGTTACGGGCTCCTGTCCAACGAGATCTCCATGGTCCAGGCAAGGGGCCGGGCCCGGGCTGGT
CGGAGCATATACTCATTTGTGGCAACCCAAGGCAGTCGGGAGCTACGACGGGAGCTGATAAACG
AGGTGCTGGAGACTTTGATGGAGCGGGCCGTGGCTGCTGTGCAGAAGATGGACCAGGCTGAGTA
CCAGGCCAAGATCCGAGATCTGCAGCAGGCAGCCCTGGTCAAGAGGGCAGTCCAGGCAGCCCAG
CGGGACAACCAGCGGCAGCAGTTCCTGGCCGAGCAGGTGCAGCTCCTCTGTGTCAACTGCATGG
TGGCTGTGGGCCACGGGAGTGACCTGCGGAAGGTGGAGGGCGCTCACCACGTCAATGTGAACCC
CAACTTCTCGATCTACTACAATGTCTCCCGGGGGCCGGTGGTCATTGACAGAACCTTCAAGGAC
TGGAGGCCTGGGGGTACCATTCACTGCAGGAACTGTGGGGAGGCCTGGGGCCTGCAGATGATCT
ACAAGTCAGTGAAGCTGCCGGCACTCAAAGTCCGCAGCATGCTTCTAGAGACACCCCGAGGGAG
AGTCCAGGCCAAGAAGTGGTCCCGTGTGCCCTTCCCCGTGCCTGACTTCGACTACCTGCAGCAC
TGTGCCCAGAACCTGGCGGACCTCTCCCTGGACTGAGCACCTCATCACTGCAGTGCCCACCTCA
GGCTGCAGGGGGCGGGACAATCCACAGCAGCCACCACCTTGGGGGGGGGGGCCAAGTCCCTCCT
GCCTGAGTCACCAGTTGGGGCACCATGCTGACCAGCCACAGAGGAAACCAGGGCGTCCAGGCTG
GCTCAGACTGTCATGCTGCGGAAGCACCTCTGAGGGCCACAGCTTAGCCCCAGAGCTCCCCTCA
TACCACAGACAT

hide sequence

RefSeq Acc Id:

XM_038485548 ⟹ XP_038341476

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	20,291,511 - 20,299,903 (+)	NCBI

RefSeq Acc Id:

XM_038485549 ⟹ XP_038341477

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	20,291,486 - 20,299,903 (+)	NCBI

RefSeq Acc Id:

XM_038485550 ⟹ XP_038341478

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	20,291,489 - 20,299,903 (+)	NCBI

RefSeq Acc Id:

XM_038547305 ⟹ XP_038403233

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	9	20,661,680 - 20,670,075 (+)	NCBI

RefSeq Acc Id:

XM_038547306 ⟹ XP_038403234

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	9	20,661,655 - 20,670,075 (+)	NCBI

RefSeq Acc Id:

XM_038547307 ⟹ XP_038403235

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	9	20,661,658 - 20,670,075 (+)	NCBI

RefSeq Acc Id:

XM_038602926 ⟹ XP_038458854

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	9	20,248,405 - 20,256,796 (+)	NCBI

RefSeq Acc Id:

XM_038611275 ⟹ XP_038467203

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	20,558,633 - 20,567,025 (+)	NCBI

RefSeq Acc Id:

XM_038611276 ⟹ XP_038467204

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	20,558,608 - 20,567,025 (+)	NCBI

RefSeq Acc Id:

XM_038611277 ⟹ XP_038467205

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	20,558,611 - 20,567,025 (+)	NCBI

RefSeq Acc Id:

XM_038676483 ⟹ XP_038532411

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	21,506,236 - 21,514,628 (+)	NCBI

RefSeq Acc Id:

XM_038676484 ⟹ XP_038532412

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	21,506,211 - 21,514,628 (+)	NCBI

RefSeq Acc Id:

XM_038676485 ⟹ XP_038532413

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	21,506,214 - 21,514,628 (+)	NCBI

RefSeq Acc Id:

XR_005330635

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	20,291,511 - 20,299,220 (+)	NCBI

RefSeq Acc Id:

XR_005330636

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	20,291,511 - 20,299,188 (+)	NCBI

RefSeq Acc Id:

XR_005394792

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	9	20,248,405 - 20,256,113 (+)	NCBI

RefSeq Acc Id:

XR_005394795

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	9	20,248,405 - 20,256,081 (+)	NCBI

RefSeq Acc Id:

XR_005398796

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	20,558,633 - 20,566,342 (+)	NCBI

RefSeq Acc Id:

XR_005398797

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	20,558,633 - 20,566,310 (+)	NCBI

RefSeq Acc Id:

XR_005432128

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	21,506,236 - 21,513,945 (+)	NCBI

RefSeq Acc Id:

XR_005432129

Type:

NON-CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	21,506,236 - 21,513,913 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_013972040	(Get FASTA)	NCBI Sequence Viewer
	XP_013972041	(Get FASTA)	NCBI Sequence Viewer
	XP_038341476	(Get FASTA)	NCBI Sequence Viewer
	XP_038341477	(Get FASTA)	NCBI Sequence Viewer
	XP_038341478	(Get FASTA)	NCBI Sequence Viewer
	XP_038403233	(Get FASTA)	NCBI Sequence Viewer
	XP_038403234	(Get FASTA)	NCBI Sequence Viewer
	XP_038403235	(Get FASTA)	NCBI Sequence Viewer
	XP_038458854	(Get FASTA)	NCBI Sequence Viewer
	XP_038467203	(Get FASTA)	NCBI Sequence Viewer
	XP_038467204	(Get FASTA)	NCBI Sequence Viewer
	XP_038467205	(Get FASTA)	NCBI Sequence Viewer
	XP_038532411	(Get FASTA)	NCBI Sequence Viewer
	XP_038532412	(Get FASTA)	NCBI Sequence Viewer
	XP_038532413	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000023103.4
	ENSCAFP00030000160.1
	ENSCAFP00030000188.1
	ENSCAFP00040014320.1
	ENSCAFP00845014250
	ENSCAFP00845014250.1

RefSeq Acc Id:	XP_013972040 ⟸ XM_014116565
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0LX22 (UniProtKB/TrEMBL), A0A8I3NFT8 (UniProtKB/TrEMBL), A0A8C0KMA9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MELRPYQWEVIMPALEGKNIIVWLPTGAGKTRAAAYVAKRHLETVDQAKVVVLVNRVHLVTQHC EEFSRMLGKRWAIITLSGDMGPRAGFGHLARSHDLIICTAELLQMALTSPEEEEHVELNAFSLL VVDECHHTHKDTVYNLILSRYLEHKLQRTRPLPQVLGLTASPGTGGASTLDGAIDHILQLCANL DTWHIMSPENHRPQLQEHSAQPCKQYSLCHRRSQDPFGDMLKKLMDRIHNRLEMPALNRDFGTQ TYEQQVVELSQDAAQAGLQQRRVYALHLRRYNDALLIHDTVRAVDALKSLGDFYDRERATKTQV LQAERWLLALFDDYKNELAHLATQTPENPKLEMLEQILREQFGHSDSPRGIIFTQTRQSTHSLL LWLQQQPGLQTVDIRADLLIGAGNSSQNTHMTQRDQQEVIRKFRVGTLNLLVATSVAEEGLDIP QCNVVVRYGLLSNEISMVQARGRARAGRSIYSFVATQGSRELRRELINEVLETLMERAVAAVQK MDQAEYQAKIRDLQQAALVKRAVQAAQRDNQRQQFLAEQVQLLCVNCMVAVGHGSDLRKVEGAH HVNVNPNFSIYYNVSRGPVVIDRTFKDWRPGGTIHCRNCGEAWGLQMIYKSVKLPALKVRSMLL ETPRGRVQAKKWSRVPFPVPDFDYLQHCAQNLADLSLD hide sequence

RefSeq Acc Id:	XP_013972041 ⟸ XM_014116566
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0LX22 (UniProtKB/TrEMBL), A0A8I3NFT8 (UniProtKB/TrEMBL), A0A8C0KMA9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MELRPYQWEVIMPALEGKNIIVWLPTGAGKTRAAAYVAKRHLETVDQAKVVVLVNRVHLVTQHC EEFSRMLGKRWAIITLSGDMGPRAGFGHLARSHDLIICTAELLQMALTSPEEEEHVELNAFSLL VVDECHHTHKDTVYNLILSRYLEHKLQRTRPLPQVLGLTASPGTGGASTLDGAIDHILQLCANL DTWHIMSPENHRPQLQEHSAQPCKQYSLCHRRSQDPFGDMLKKLMDRIHNRLEMPALNRDFGTQ TYEQQVVELSQDAAQAGLQQRRVYALHLRRYNDALLIHDTVRAVDALKSLGDFYDRERATKTQV LQAERWLLALFDDYKNELAHLATQTPENPKLEMLEQILREQFGHSDSPRGIIFTQTRQSTHSLL LWLQQQPGLQTVDIRADLLIGAGNSSQNTHMTQRDQQEVIRKFRVGTLNLLVATSVAEEGLDIP QCNVVVRYGLLSNEISMVQARGRARAGRSIYSFVATQGSRELRRELINEVLETLMERAVAAVQK MDQAEYQAKIRDLQQAALVKRAVQAAQRDNQRQQFLAEQVQLLCVNCMVAVGHGSDLRKVEGAH HVNVNPNFSIYYNVSRGPVVIDRTFKDWRPGGTIHCRNCGEAWGLQMIYKSVKLPALKVRSMLL ETPRGRVQAKKWSRVPFPVPDFDYLQHCAQNLADLSLD hide sequence

RefSeq Acc Id:

ENSCAFP00000023103 ⟸ ENSCAFT00000024900

RefSeq Acc Id:	XP_038341477 ⟸ XM_038485549
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038341478 ⟸ XM_038485550
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038341476 ⟸ XM_038485548
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038467204 ⟸ XM_038611276
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038467205 ⟸ XM_038611277
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038467203 ⟸ XM_038611275
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038532412 ⟸ XM_038676484
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0LX22 (UniProtKB/TrEMBL), A0A8I3NFT8 (UniProtKB/TrEMBL), A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038532413 ⟸ XM_038676485
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0LX22 (UniProtKB/TrEMBL), A0A8I3NFT8 (UniProtKB/TrEMBL), A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038532411 ⟸ XM_038676483
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0LX22 (UniProtKB/TrEMBL), A0A8I3NFT8 (UniProtKB/TrEMBL), A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038458854 ⟸ XM_038602926
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0LX22 (UniProtKB/TrEMBL), A0A8I3NFT8 (UniProtKB/TrEMBL), A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038403234 ⟸ XM_038547306
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038403235 ⟸ XM_038547307
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038403233 ⟸ XM_038547305
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KMA9 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845014250 ⟸ ENSCAFT00845018265

Protein Domains

Helicase ATP-binding Helicase C-terminal RLR CTR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000015720	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030000133	UniProtKB/TrEMBL
	ENSCAFG00040008794	UniProtKB/TrEMBL
	ENSCAFG00845010366	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000024900.5	UniProtKB/TrEMBL
	ENSCAFT00030000190.1	UniProtKB/TrEMBL
	ENSCAFT00030000221.1	UniProtKB/TrEMBL
	ENSCAFT00040016526.1	UniProtKB/TrEMBL
	ENSCAFT00845018265	ENTREZGENE
	ENSCAFT00845018265.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1320.30	UniProtKB/TrEMBL
	2.170.150.30	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	Helicase/UvrB_N	UniProtKB/TrEMBL
	Helicase_ATP-bd	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RIG-I_C	UniProtKB/TrEMBL
	RLR_C_sf	UniProtKB/TrEMBL
	RLR_CTR	UniProtKB/TrEMBL
KEGG Report	cfa:607803	UniProtKB/TrEMBL
NCBI Gene	DHX58	ENTREZGENE
PANTHER	ATP-DEPENDENT RNA HELICASE DHX58-RELATED	UniProtKB/TrEMBL
	HELICASE WITH DEATH DOMAIN-RELATED	UniProtKB/TrEMBL
Pfam	Helicase_C	UniProtKB/TrEMBL
	ResIII	UniProtKB/TrEMBL
	RIG-I_C	UniProtKB/TrEMBL
	RIG-I_C-RD	UniProtKB/TrEMBL
PROSITE	HELICASE_ATP_BIND_1	UniProtKB/TrEMBL
	HELICASE_CTER	UniProtKB/TrEMBL
	RLR_CTR	UniProtKB/TrEMBL
SMART	DEXDc	UniProtKB/TrEMBL
	HELICc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C0KMA9	ENTREZGENE
	A0A8C0LQH6_CANLF	UniProtKB/TrEMBL
	A0A8C0LX22	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NFT8	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:39951	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar