CSF2RA (colony stimulating factor 2 receptor subunit alpha) - Rat Genome Database

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Gene: CSF2RA (colony stimulating factor 2 receptor subunit alpha) Canis lupus familiaris
Analyze
Symbol: CSF2RA
Name: colony stimulating factor 2 receptor subunit alpha
RGD ID: 12304352
Description: ENCODES a protein that exhibits cytokine binding (inferred); cytokine receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); granulocyte-macrophage colony-stimulating factor signaling pathway (ortholog); positive regulation of leukocyte proliferation (ortholog); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); pulmonary alveolar proteinosis (ortholog); Pulmonary Surfactant Metabolism Dysfunction 4 (ortholog); FOUND IN granulocyte macrophage colony-stimulating factor receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor subunit alpha
RGD Orthologs
Human
Mouse
Rat
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X832,170 - 855,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX832,046 - 853,876 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX772,774 - 796,202 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X742,740 - 766,122 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X734,899 - 758,240 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X751,242 - 774,663 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X748,192 - 771,608 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CSF2RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X832,170 - 855,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX832,046 - 853,876 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX772,774 - 796,202 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X742,740 - 766,122 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X734,899 - 758,240 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X751,242 - 774,663 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X748,192 - 771,608 (+)NCBIUU_Cfam_GSD_1.0
CSF2RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y1,268,814 - 1,325,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X1,268,814 - 1,325,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX1,268,800 - 1,310,381 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 EnsemblY1,268,800 - 1,310,381 (+)EnsemblGRCh38hg38GRCh38
GRCh37Y1,337,707 - 1,394,111 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37X1,387,707 - 1,444,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y1,347,701 - 1,388,827 (+)NCBINCBI36Build 36hg18NCBI36
Build 36X1,347,701 - 1,388,827 (+)NCBINCBI36Build 36hg18NCBI36
Build 34Y1,355,172 - 1,396,299NCBI
CeleraX5,684,057 - 5,726,879 (+)NCBICelera
Cytogenetic MapX;YNCBI
CHM1_1X1,418,017 - 1,458,211 (+)NCBICHM1_1
T2T-CHM13v2.0Y1,129,416 - 1,189,240 (+)NCBIT2T-CHM13v2.0
T2T-CHM13v2.0X1,116,126 - 1,174,802 (+)NCBIT2T-CHM13v2.0
Csf2ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391961,205,629 - 61,221,141 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1961,212,395 - 61,216,867 (-)EnsemblGRCm39 Ensembl
GRCm381961,217,191 - 61,228,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1961,223,957 - 61,228,429 (-)EnsemblGRCm38mm10GRCm38
MGSCv371961,300,305 - 61,304,321 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361961,279,074 - 61,283,022 (-)NCBIMGSCv36mm8
Celera1963,421,543 - 63,425,590 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.89NCBI
Csf2ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814113,219 - 118,808 (-)NCBIGRCr8
mRatBN7.21498,089 - 103,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1489,172 - 103,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14116,168 - 121,062 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0141,417,943 - 1,422,837 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014114,615 - 119,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0141,462,292 - 1,467,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,462,358 - 1,467,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,465,139 - 1,469,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera14661,818 - 666,688 (+)NCBICelera
Cytogenetic Map14p22NCBI
LOC101965277
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404953534,206 - 541,365 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366443,835,462 - 3,842,471 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF2RA
(Sus scrofa - pig)		 No map positions available.
LOC103247514
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666141112,013 - 168,815 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf2ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624834616,180 - 628,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CSF2RA
580 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 2 18 6 6 6 6 10 8 4
Below cutoff 3 5 4 6 2 8 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005641054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005641059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038522694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038522695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038522696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038586705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038586706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038586707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002624325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005309177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005351936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005386048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005419848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000017564   ⟹   ENSCAFP00000016261
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX832,046 - 853,876 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000037166   ⟹   ENSCAFP00000032623
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX832,046 - 853,876 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000085811   ⟹   ENSCAFP00000063278
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX832,046 - 850,013 (+)Ensembl
RefSeq Acc Id: XM_005641054   ⟹   XP_005641111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X832,170 - 855,548 (+)NCBI
Dog10K_Boxer_TashaX772,776 - 796,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005641059   ⟹   XP_005641116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X832,170 - 855,548 (+)NCBI
Dog10K_Boxer_TashaX772,776 - 796,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022416018   ⟹   XP_022271726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X832,177 - 855,548 (+)NCBI
Dog10K_Boxer_TashaX772,774 - 796,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038449260   ⟹   XP_038305188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X742,742 - 766,122 (+)NCBI
RefSeq Acc Id: XM_038449261   ⟹   XP_038305189
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X742,740 - 766,122 (+)NCBI
RefSeq Acc Id: XM_038449262   ⟹   XP_038305190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X742,742 - 766,122 (+)NCBI
RefSeq Acc Id: XM_038522694   ⟹   XP_038378622
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X734,901 - 758,240 (+)NCBI
RefSeq Acc Id: XM_038522695   ⟹   XP_038378623
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X734,899 - 758,240 (+)NCBI
RefSeq Acc Id: XM_038522696   ⟹   XP_038378624
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X734,901 - 758,240 (+)NCBI
RefSeq Acc Id: XM_038586705   ⟹   XP_038442633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X748,194 - 771,608 (+)NCBI
RefSeq Acc Id: XM_038586706   ⟹   XP_038442634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X748,192 - 771,608 (+)NCBI
RefSeq Acc Id: XM_038586707   ⟹   XP_038442635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X748,194 - 771,608 (+)NCBI
RefSeq Acc Id: XM_038651206   ⟹   XP_038507134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X751,244 - 774,663 (+)NCBI
RefSeq Acc Id: XM_038651207   ⟹   XP_038507135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X751,242 - 774,663 (+)NCBI
RefSeq Acc Id: XM_038651208   ⟹   XP_038507136
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X751,244 - 774,663 (+)NCBI
RefSeq Acc Id: XR_002624325
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X832,170 - 851,549 (+)NCBI
Dog10K_Boxer_TashaX772,776 - 792,223 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005309177
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X742,742 - 762,140 (+)NCBI
RefSeq Acc Id: XR_005351936
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X734,901 - 754,264 (+)NCBI
RefSeq Acc Id: XR_005386048
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X748,194 - 767,626 (+)NCBI
RefSeq Acc Id: XR_005419848
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X751,244 - 770,681 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005641111   ⟸   XM_005641054
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PBB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005641116   ⟸   XM_005641059
- Peptide Label: isoform X3
- UniProtKB: A0A8I3S2B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022271726   ⟸   XM_022416018
- Peptide Label: isoform X2
- UniProtKB: A0A8I3P791 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016261   ⟸   ENSCAFT00000017564
RefSeq Acc Id: ENSCAFP00000032623   ⟸   ENSCAFT00000037166
RefSeq Acc Id: ENSCAFP00000063278   ⟸   ENSCAFT00000085811
RefSeq Acc Id: XP_038378623   ⟸   XM_038522695
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038378622   ⟸   XM_038522694
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038378624   ⟸   XM_038522696
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038507135   ⟸   XM_038651207
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038507134   ⟸   XM_038651206
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038507136   ⟸   XM_038651208
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038305189   ⟸   XM_038449261
- Peptide Label: isoform X2
- UniProtKB: A0A8I3P791 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038305188   ⟸   XM_038449260
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PBB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038305190   ⟸   XM_038449262
- Peptide Label: isoform X3
- UniProtKB: A0A8I3S2B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038442634   ⟸   XM_038586706
- Peptide Label: isoform X2
- UniProtKB: A0A8I3P791 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038442633   ⟸   XM_038586705
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PBB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038442635   ⟸   XM_038586707
- Peptide Label: isoform X3
- UniProtKB: A0A8I3S2B1 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   IL-3 receptor alpha chain N-terminal   Type I cytokine receptor cytokine-binding

Promoters
RGD ID:13689241
Promoter ID:EPDNEW_C7307
Type:single initiation site
Name:CSF2RA_1
Description:colony stimulating factor 2 receptor alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X832,194 - 832,254EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011041 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845021143 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000037166.5 UniProtKB/TrEMBL
  ENSCAFT00845037345 ENTREZGENE
  ENSCAFT00845037345.1 UniProtKB/TrEMBL
  ENSCAFT00845037484 ENTREZGENE
  ENSCAFT00845037484.1 UniProtKB/TrEMBL
  ENSCAFT00845037599 ENTREZGENE
  ENSCAFT00845037599.1 UniProtKB/TrEMBL
  ENSCAFT00845037728.1 UniProtKB/TrEMBL
  ENSCAFT00845037805.1 UniProtKB/TrEMBL
  ENSCAFT00845037857.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  IL3Ra_N UniProtKB/TrEMBL
  Short_hematopoietin_rcpt_2_CS UniProtKB/TrEMBL
  TypeI_recpt_CBD UniProtKB/TrEMBL
NCBI Gene CSF2RA ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam IL3Ra_N UniProtKB/TrEMBL
  IL6Ra-bind UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt A0A8I3P791 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P7R2_CANLF UniProtKB/TrEMBL
  A0A8I3PBB4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PD68_CANLF UniProtKB/TrEMBL
  A0A8I3PGN8_CANLF UniProtKB/TrEMBL
  A0A8I3S2B1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NM35_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:39655 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-10 CSF2RA  colony stimulating factor 2 receptor subunit alpha  CSF2RA  colony stimulating factor 2 receptor alpha subunit  Symbol and/or name change 5135510 APPROVED