EPHB2 (EPH receptor B2) - Rat Genome Database

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Gene: EPHB2 (EPH receptor B2) Canis lupus familiaris
Analyze
Symbol: EPHB2
Name: EPH receptor B2
RGD ID: 12300377
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); axon guidance receptor activity (ortholog); ephrin receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; syndecan signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anorectal Malformations (ortholog); Candidemia (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ephrin type-B receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
axon guidance  (IBA,ISO)
axonal fasciculation  (ISO)
B cell activation  (ISO)
camera-type eye morphogenesis  (ISO)
cell morphogenesis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
central nervous system projection neuron axonogenesis  (IBA,ISO)
commissural neuron axon guidance  (ISO)
corpus callosum development  (ISO)
dendritic spine development  (ISO)
dendritic spine morphogenesis  (ISO)
ephrin receptor signaling pathway  (IEA,ISO)
hindbrain tangential cell migration  (ISO)
inner ear morphogenesis  (ISO)
learning  (ISO)
learning or memory  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
neuron projection retraction  (ISO)
optic nerve morphogenesis  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
phosphorylation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
postsynaptic membrane assembly  (ISO)
protein phosphorylation  (ISO)
regulation of axonogenesis  (ISO)
regulation of behavioral fear response  (ISO)
regulation of blood coagulation  (ISO)
regulation of body fluid levels  (ISO)
regulation of filopodium assembly  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of synapse assembly  (ISO)
regulation of T-helper 17 type immune response  (ISO)
retinal ganglion cell axon guidance  (ISO)
roof of mouth development  (ISO)
tight junction assembly  (ISO)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,ISO)
urogenital system development  (ISO)
vesicle-mediated intercellular transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
EPHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
EPHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,710,770 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
Ephb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBImm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
Ephb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,889,574 - 149,077,027 (-)NCBI
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ephb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
EPHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0panPan3
Ephb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBI
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,747,883 - 109,954,936 (-)NCBI
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)Ensembl
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBI
Ephb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 15 3 6 12 6 6
Below cutoff 5 5 4 3 4 6 8 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005617823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005617824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014110690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000023227   ⟹   ENSCAFP00000021569
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073617   ⟹   ENSCAFP00000056586
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083865   ⟹   ENSCAFP00000056329
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl276,446,096 - 76,612,786 (-)Ensembl
RefSeq Acc Id: XM_005617823   ⟹   XP_005617880
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1276,427,112 - 76,551,494 (-)NCBI
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005617824   ⟹   XP_005617881
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1276,427,112 - 76,551,494 (-)NCBI
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014110690   ⟹   XP_013966165
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1276,427,112 - 76,551,494 (-)NCBI
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038470794   ⟹   XP_038326722
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
RefSeq Acc Id: XM_038470795   ⟹   XP_038326723
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
RefSeq Acc Id: XM_038470796   ⟹   XP_038326724
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
RefSeq Acc Id: XM_038531657   ⟹   XP_038387585
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
RefSeq Acc Id: XM_038531658   ⟹   XP_038387586
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
RefSeq Acc Id: XM_038531659   ⟹   XP_038387587
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
RefSeq Acc Id: XM_038595887   ⟹   XP_038451815
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,815,673 - 74,907,551 (-)NCBI
RefSeq Acc Id: XM_038595888   ⟹   XP_038451816
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,815,673 - 74,907,551 (-)NCBI
RefSeq Acc Id: XM_038595889   ⟹   XP_038451817
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
RefSeq Acc Id: XM_038595890   ⟹   XP_038451818
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
RefSeq Acc Id: XM_038659966   ⟹   XP_038515894
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
RefSeq Acc Id: XM_038659967   ⟹   XP_038515895
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
RefSeq Acc Id: XM_038659968   ⟹   XP_038515896
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_013966165   ⟸   XM_014110690
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005617881   ⟸   XM_005617824
- Peptide Label: isoform X2
- UniProtKB: F1PAF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005617880   ⟸   XM_005617823
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000056586   ⟸   ENSCAFT00000073617
RefSeq Acc Id: ENSCAFP00000056329   ⟸   ENSCAFT00000083865
RefSeq Acc Id: ENSCAFP00000021569   ⟸   ENSCAFT00000023227
RefSeq Acc Id: XP_038326724   ⟸   XM_038470796
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038326723   ⟸   XM_038470795
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038326722   ⟸   XM_038470794
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451818   ⟸   XM_038595890
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038451817   ⟸   XM_038595889
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038451816   ⟸   XM_038595888
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038451815   ⟸   XM_038595887
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038515896   ⟸   XM_038659968
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038515895   ⟸   XM_038659967
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038515894   ⟸   XM_038659966
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038387587   ⟸   XM_038531659
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038387586   ⟸   XM_038531658
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038387585   ⟸   XM_038531657
- Peptide Label: isoform X1
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014323 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000021569 ENTREZGENE
  ENSCAFP00000056586 ENTREZGENE
NCBI Gene EPHB2 ENTREZGENE
UniProt F1PAF1 ENTREZGENE
VGNC ID VGNC:40411 ENTREZGENE