TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) - Rat Genome Database

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Gene: TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) Canis lupus familiaris
Analyze
Symbol: TCIRG1
Name: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
RGD ID: 12297718
Description: ENCODES a protein that exhibits ATPase binding (inferred); proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN apoptotic process (ortholog); autophagosome assembly (ortholog); autophagy (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal recessive osteopetrosis 1 (ortholog); choreaacanthocytosis (ortholog); FOUND IN apical plasma membrane (inferred); late endosome (inferred); lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a isoform 3; V-type proton ATPase 116 kDa subunit a3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,784,480 - 49,794,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,784,490 - 49,794,317 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,393,818 - 48,403,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,705,711 - 50,715,580 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,703,574 - 50,715,558 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,919,281 - 49,929,147 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,494,101 - 49,503,970 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,287,643 - 50,297,518 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
autophagosome assembly  (IEA,ISO)
autophagy  (IEA,ISO)
B cell differentiation  (IEA,ISO)
bone resorption  (IEA,ISO)
cellular response to cytokine stimulus  (IEA,ISO)
dentin mineralization  (IEA,ISO)
enamel mineralization  (IEA,ISO)
establishment of cell polarity  (IEA,ISO)
establishment of vesicle localization  (IEA,ISO)
gene expression  (IEA,ISO)
hematopoietic stem cell homeostasis  (IEA,ISO)
homeostasis of number of cells  (IEA,ISO)
immunoglobulin mediated immune response  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular pH reduction  (IEA,ISO)
macroautophagy  (IEA,ISO)
memory T cell activation  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
odontogenesis  (IEA,ISO)
optic nerve development  (IEA,ISO)
ossification  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
osteoclast proliferation  (IEA,ISO)
pH reduction  (IEA,ISO)
phagosome acidification  (IEA,ISO)
protein catabolic process in the vacuole  (IEA,ISO)
protein localization to organelle  (IEA,ISO)
proton transmembrane transport  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of insulin secretion  (IEA,ISO)
regulation of osteoblast differentiation  (IEA,ISO)
regulation of proton transport  (IEA,ISO)
response to silver ion  (IEA,ISO)
retina development in camera-type eye  (IEA,ISO)
ruffle organization  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
T-helper 1 cell activation  (IEA,ISO)
tooth eruption  (IEA,ISO)
vacuolar acidification  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TCIRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,784,480 - 49,794,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,784,490 - 49,794,317 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,393,818 - 48,403,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,705,711 - 50,715,580 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,703,574 - 50,715,558 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,919,281 - 49,929,147 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,494,101 - 49,503,970 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,287,643 - 50,297,518 (-)NCBIUU_Cfam_GSD_1.0
TCIRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,039,025 - 68,053,762 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,039,025 - 68,050,895 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,806,492 - 67,818,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,563,059 - 67,574,942 (+)NCBINCBI36Build 36hg18NCBI36
Celera1165,140,155 - 65,152,040 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,141,805 - 64,153,709 (+)NCBIHuRef
CHM1_11167,690,218 - 67,702,120 (+)NCBICHM1_1
T2T-CHM13v2.01168,042,666 - 68,057,403 (+)NCBIT2T-CHM13v2.0
Tcirg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,946,050 - 3,957,717 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,946,050 - 3,957,133 (-)EnsemblGRCm39 Ensembl
GRCm38193,896,050 - 3,907,133 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,896,050 - 3,907,133 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,896,050 - 3,907,133 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,896,053 - 3,905,230 (-)NCBIMGSCv36mm8
Celera193,776,425 - 3,787,508 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.62NCBI
Tcirg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,556,270 - 210,568,021 (-)NCBIGRCr8
mRatBN7.21201,127,034 - 201,138,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,127,034 - 201,138,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,500,301 - 209,509,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,589,084 - 216,598,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,263,286 - 209,272,675 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,126,687 - 219,139,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,127,602 - 219,139,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,999,292 - 226,012,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,420,106 - 206,429,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,573,497 - 206,585,222 (-)NCBI
Celera1198,679,648 - 198,689,037 (-)NCBICelera
Cytogenetic Map1q43NCBI
Tcirg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,768,469 - 17,779,003 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,768,469 - 17,778,976 (-)NCBIChiLan1.0ChiLan1.0
TCIRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,989,593 - 69,001,506 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,032,855 - 70,044,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,120,913 - 63,132,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,429,435 - 66,441,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,429,435 - 66,441,327 (+)Ensemblpanpan1.1panPan2
Tcirg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,627,790 - 5,636,842 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,066,847 - 2,079,206 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,070,211 - 2,079,169 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCIRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,844,637 - 4,860,498 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,844,627 - 4,860,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,476,372 - 3,488,494 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCIRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,484,469 - 6,497,008 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,484,474 - 6,494,719 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,762,696 - 103,775,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcirg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,809,689 - 18,820,390 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,809,626 - 18,820,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TCIRG1
123 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 6 6 1 10 4
Low 5 5 12 6 6 6 11 8 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017517   ⟹   ENSCAFP00000016218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1849,784,490 - 49,794,317 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014897   ⟹   ENSCAFP00845011548
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1850,703,574 - 50,714,375 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845015137   ⟹   ENSCAFP00845011749
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1850,705,713 - 50,715,558 (-)Ensembl
RefSeq Acc Id: XM_005631394   ⟹   XP_005631451
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11849,784,480 - 49,794,342 (-)NCBI
Dog10K_Boxer_Tasha1848,393,818 - 48,403,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038424770   ⟹   XP_038280698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01850,705,711 - 50,715,580 (-)NCBI
RefSeq Acc Id: XM_038424771   ⟹   XP_038280699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01850,705,711 - 50,715,573 (-)NCBI
RefSeq Acc Id: XM_038501022   ⟹   XP_038356950
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11849,919,281 - 49,929,147 (-)NCBI
RefSeq Acc Id: XM_038501023   ⟹   XP_038356951
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11849,919,281 - 49,929,140 (-)NCBI
RefSeq Acc Id: XM_038563709   ⟹   XP_038419637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01850,287,643 - 50,297,518 (-)NCBI
RefSeq Acc Id: XM_038563710   ⟹   XP_038419638
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01850,287,643 - 50,297,511 (-)NCBI
RefSeq Acc Id: XM_038627830   ⟹   XP_038483758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01849,494,101 - 49,503,970 (-)NCBI
RefSeq Acc Id: XM_038627831   ⟹   XP_038483759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01849,494,101 - 49,503,963 (-)NCBI
RefSeq Acc Id: XM_540812   ⟹   XP_540812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11849,784,480 - 49,794,361 (-)NCBI
Dog10K_Boxer_Tasha1848,393,818 - 48,403,688 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_540812   ⟸   XM_540812
- UniProtKB: A0A8C0YR98 (UniProtKB/TrEMBL),   A0A8P0SFX1 (UniProtKB/TrEMBL),   A0A8P0TKS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005631451   ⟸   XM_005631394
- UniProtKB: A0A8C0YR98 (UniProtKB/TrEMBL),   A0A8P0SFX1 (UniProtKB/TrEMBL),   A0A8P0TKS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016218   ⟸   ENSCAFT00000017517
RefSeq Acc Id: XP_038356950   ⟸   XM_038501022
RefSeq Acc Id: XP_038356951   ⟸   XM_038501023
RefSeq Acc Id: XP_038483758   ⟸   XM_038627830
RefSeq Acc Id: XP_038483759   ⟸   XM_038627831
RefSeq Acc Id: XP_038280698   ⟸   XM_038424770
- UniProtKB: A0A8C0QTT2 (UniProtKB/TrEMBL),   A0A8I3MZT8 (UniProtKB/TrEMBL),   A0A8I3RUK9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038280699   ⟸   XM_038424771
- UniProtKB: A0A8C0QTT2 (UniProtKB/TrEMBL),   A0A8I3MZT8 (UniProtKB/TrEMBL),   A0A8I3RUK9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419637   ⟸   XM_038563709
- UniProtKB: A0A8C0QTT2 (UniProtKB/TrEMBL),   A0A8I3MZT8 (UniProtKB/TrEMBL),   A0A8I3RUK9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419638   ⟸   XM_038563710
- UniProtKB: A0A8C0QTT2 (UniProtKB/TrEMBL),   A0A8I3MZT8 (UniProtKB/TrEMBL),   A0A8I3RUK9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011749   ⟸   ENSCAFT00845015137
RefSeq Acc Id: ENSCAFP00845011548   ⟸   ENSCAFT00845014897


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010972 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022649 UniProtKB/TrEMBL
  ENSCAFG00040008963 UniProtKB/TrEMBL
  ENSCAFG00845008465 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017517.5 UniProtKB/TrEMBL
  ENSCAFT00000109600.1 UniProtKB/TrEMBL
  ENSCAFT00030041626.1 UniProtKB/TrEMBL
  ENSCAFT00030041718.1 UniProtKB/TrEMBL
  ENSCAFT00040016665.1 UniProtKB/TrEMBL
  ENSCAFT00040016798.1 UniProtKB/TrEMBL
  ENSCAFT00845014897.1 UniProtKB/TrEMBL
  ENSCAFT00845015137 ENTREZGENE
  ENSCAFT00845015137.1 UniProtKB/TrEMBL
InterPro V-ATPase_116kDa_su UniProtKB/TrEMBL
  V-type_ATPase_116kDa_su_euka UniProtKB/TrEMBL
KEGG Report cfa:483691 UniProtKB/TrEMBL
NCBI Gene TCIRG1 ENTREZGENE
PANTHER PTHR11629 UniProtKB/TrEMBL
  V-TYPE PROTON ATPASE 116 KDA SUBUNIT A3 UniProtKB/TrEMBL
Pfam V_ATPase_I UniProtKB/TrEMBL
PIRSF ATP6V0A1 UniProtKB/TrEMBL
UniProt A0A8C0PAR4_CANLF UniProtKB/TrEMBL
  A0A8C0QTT2 ENTREZGENE
  A0A8C0S1E8_CANLF UniProtKB/TrEMBL
  A0A8C0YR98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MZT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RUK9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SFX1 ENTREZGENE
  A0A8P0TKS4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0SFX1 UniProtKB/TrEMBL
VGNC ID VGNC:47203 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 TCIRG1  T cell immune regulator 1, ATPase H+ transporting V0 subunit a3    T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3  Symbol and/or name change 5135510 APPROVED