DHX37 (DEAH-box helicase 37) - Rat Genome Database

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Gene: DHX37 (DEAH-box helicase 37) Canis lupus familiaris
Analyze
Symbol: DHX37
Name: DEAH-box helicase 37
RGD ID: 12294263
Description: ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); nucleic acid binding (inferred); INVOLVED IN brain development (inferred); maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (inferred); positive regulation of male gonad development (inferred); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Anorchia (ortholog); coloboma of optic nerve (ortholog); epilepsy (ortholog); FOUND IN cytoplasm (inferred); nuclear membrane (inferred); nucleolus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: probable ATP-dependent RNA helicase DHX37
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,964,038 - 4,993,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,964,088 - 4,993,930 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,123,783 - 5,153,463 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,206,304 - 5,239,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,206,299 - 5,239,486 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,144,401 - 5,174,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,233,830 - 5,263,493 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,187,762 - 5,217,659 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DHX37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,964,038 - 4,993,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,964,088 - 4,993,930 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,123,783 - 5,153,463 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,206,304 - 5,239,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,206,299 - 5,239,486 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,144,401 - 5,174,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,233,830 - 5,263,493 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,187,762 - 5,217,659 (+)NCBIUU_Cfam_GSD_1.0
DHX37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812124,946,826 - 124,989,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12124,946,825 - 124,989,131 (-)EnsemblGRCh38hg38GRCh38
GRCh3712125,431,372 - 125,473,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612123,997,325 - 124,039,620 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412123,956,252 - 123,998,547NCBI
Celera12125,032,659 - 125,074,871 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,392,649 - 122,434,920 (-)NCBIHuRef
CHM1_112125,252,790 - 125,294,963 (-)NCBICHM1_1
T2T-CHM13v2.012124,952,035 - 124,994,326 (-)NCBIT2T-CHM13v2.0
Dhx37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,490,811 - 125,511,203 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,490,922 - 125,511,185 (-)EnsemblGRCm39 Ensembl
GRCm385125,413,747 - 125,434,139 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,413,858 - 125,434,121 (-)EnsemblGRCm38mm10GRCm38
MGSCv375125,894,774 - 125,914,418 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,703,780 - 125,723,424 (-)NCBIMGSCv36mm8
Celera5122,436,431 - 122,456,078 (-)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.2NCBI
Dhx37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,856,119 - 36,876,245 (+)NCBIGRCr8
mRatBN7.21231,194,782 - 31,214,890 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,194,859 - 31,216,802 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,365,513 - 32,385,572 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,976,940 - 32,996,999 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,028,862 - 32,048,921 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,594,058 - 36,614,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,594,047 - 36,614,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,472,183 - 38,492,290 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,288,945 - 32,309,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,152,405 - 32,171,800 (+)NCBI
Celera1232,889,308 - 32,909,392 (+)NCBICelera
Cytogenetic Map12q14NCBI
Dhx37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554824,731,675 - 4,756,632 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554824,733,720 - 4,754,754 (+)NCBIChiLan1.0ChiLan1.0
DHX37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210133,032,061 - 133,076,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112133,028,439 - 133,073,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,539,236 - 122,582,819 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,823,006 - 126,865,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12126,823,006 - 126,865,933 (-)Ensemblpanpan1.1panPan2
Dhx37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118159,037,789 - 159,060,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558418,983 - 444,538 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936558418,998 - 441,637 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,211,579 - 28,242,435 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11428,206,152 - 28,242,436 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21429,908,883 - 29,944,337 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHX37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,304,767 - 120,347,439 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11120,304,314 - 120,347,227 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037124,938,036 - 124,981,360 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhx37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474724,055,707 - 24,074,919 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474724,054,577 - 24,075,011 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DHX37
340 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 14 6 6 5 8 5
Low 5 5 8 6 6 6 7 8 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011159   ⟹   ENSCAFP00000010337
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,964,088 - 4,993,930 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054248   ⟹   ENSCAFP00845042619
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl265,206,299 - 5,239,486 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054259   ⟹   ENSCAFP00845042626
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl265,206,299 - 5,239,486 (+)Ensembl
RefSeq Acc Id: XM_038436162   ⟹   XP_038292090
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,206,304 - 5,239,487 (+)NCBI
RefSeq Acc Id: XM_038511273   ⟹   XP_038367201
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1265,144,401 - 5,174,095 (+)NCBI
RefSeq Acc Id: XM_038574748   ⟹   XP_038430676
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0265,187,762 - 5,217,659 (+)NCBI
RefSeq Acc Id: XM_038638943   ⟹   XP_038494871
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0265,233,830 - 5,263,493 (+)NCBI
RefSeq Acc Id: XM_534640   ⟹   XP_534640
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1264,964,038 - 4,993,932 (+)NCBI
Dog10K_Boxer_Tasha265,123,783 - 5,153,463 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_534640   ⟸   XM_534640
- Peptide Label: isoform X5
- UniProtKB: A0A8C0KHH9 (UniProtKB/TrEMBL),   A0A8C0TL89 (UniProtKB/TrEMBL),   A0A8P0SCA8 (UniProtKB/TrEMBL),   A0A8C0P543 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010337   ⟸   ENSCAFT00000011159
RefSeq Acc Id: XP_038367201   ⟸   XM_038511273
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038494871   ⟸   XM_038638943
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038292090   ⟸   XM_038436162
- Peptide Label: isoform X1
- UniProtKB: A0A8I3Q9W9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038430676   ⟸   XM_038574748
- Peptide Label: isoform X4
- UniProtKB: A0A8C0KHH9 (UniProtKB/TrEMBL),   A0A8C0P543 (UniProtKB/TrEMBL),   A0A8C0TL89 (UniProtKB/TrEMBL),   A0A8P0SCA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845042626   ⟸   ENSCAFT00845054259
RefSeq Acc Id: ENSCAFP00845042619   ⟸   ENSCAFT00845054248
Protein Domains
Helicase ATP-binding   Helicase C-terminal

Promoters
RGD ID:13687865
Promoter ID:EPDNEW_C5933
Type:initiation region
Name:DHX37_1
Description:DEAH-box helicase 37
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1264,964,063 - 4,964,123EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006952 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018529 UniProtKB/TrEMBL
  ENSCAFG00040022878 UniProtKB/TrEMBL
  ENSCAFG00845030575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011159.5 UniProtKB/TrEMBL
  ENSCAFT00000098095.1 UniProtKB/TrEMBL
  ENSCAFT00030034117.1 UniProtKB/TrEMBL
  ENSCAFT00030034220.1 UniProtKB/TrEMBL
  ENSCAFT00040042549.1 UniProtKB/TrEMBL
  ENSCAFT00845054248 ENTREZGENE
  ENSCAFT00845054248.1 UniProtKB/TrEMBL
  ENSCAFT00845054259.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2130 UniProtKB/TrEMBL
  1.20.120.1080 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DEAH_win-hel_dom UniProtKB/TrEMBL
  DUF1605 UniProtKB/TrEMBL
  HA2_WH UniProtKB/TrEMBL
  Helicase-assoc_dom UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:477442 UniProtKB/TrEMBL
NCBI Gene DHX37 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE DHX37-RELATED UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HA2_C UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  OB_NTP_bind UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0KHH9 ENTREZGENE
  A0A8C0P543 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TL89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q9W9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QAU9_CANLF UniProtKB/TrEMBL
  A0A8P0SCA8 ENTREZGENE
  A0A8P0TNK4_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0SCA8 UniProtKB/TrEMBL
VGNC ID VGNC:39947 ENTREZGENE