TTYH2 (tweety family member 2) - Rat Genome Database

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Gene: TTYH2 (tweety family member 2) Canis lupus familiaris
Analyze
Symbol: TTYH2
Name: tweety family member 2
RGD ID: 12293664
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); chloride channel activity (ortholog); volume-sensitive anion channel activity (ortholog); INVOLVED IN L-glutamate transmembrane transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN chloride channel complex (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC106559221; tweety homolog 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.196,120,586 - 6,156,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl96,120,575 - 6,156,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,742,365 - 6,778,896 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,792,981 - 6,829,555 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,792,986 - 6,829,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,833,458 - 6,870,176 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,936,998 - 6,973,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,996,992 - 7,033,550 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TTYH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.196,120,586 - 6,156,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl96,120,575 - 6,156,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,742,365 - 6,778,896 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,792,981 - 6,829,555 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,792,986 - 6,829,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,833,458 - 6,870,176 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,936,998 - 6,973,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,996,992 - 7,033,550 (-)NCBIUU_Cfam_GSD_1.0
TTYH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,213,571 - 74,262,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1774,213,571 - 74,262,020 (+)EnsemblGRCh38hg38GRCh38
GRCh371772,209,710 - 72,258,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361769,721,291 - 69,769,754 (+)NCBINCBI36Build 36hg18NCBI36
Build 341769,756,099 - 69,769,750NCBI
Celera1768,796,241 - 68,850,209 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1767,620,155 - 67,668,483 (+)NCBIHuRef
CHM1_11772,274,323 - 72,322,720 (+)NCBICHM1_1
T2T-CHM13v2.01775,104,409 - 75,152,817 (+)NCBIT2T-CHM13v2.0
Ttyh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911114,566,294 - 114,611,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11114,566,257 - 114,611,803 (+)EnsemblGRCm39 Ensembl
GRCm3811114,675,468 - 114,720,984 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11114,675,431 - 114,720,977 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711114,536,782 - 114,582,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611114,491,558 - 114,537,074 (+)NCBIMGSCv36mm8
Celera11126,434,785 - 126,481,284 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1179.85NCBI
Ttyh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,208,129 - 100,252,505 (+)NCBIGRCr8
mRatBN7.21099,709,063 - 99,753,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1099,709,007 - 99,753,444 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10104,767,015 - 104,811,823 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010104,230,134 - 104,274,937 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01099,630,130 - 99,674,500 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,206,085 - 103,248,911 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,206,014 - 103,248,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010102,865,658 - 102,908,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410104,553,284 - 104,596,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1098,313,869 - 98,344,814 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Ttyh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,137,762 - 1,179,195 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555531,137,762 - 1,179,195 (+)NCBIChiLan1.0ChiLan1.0
TTYH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21990,244,278 - 90,292,730 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,066,716 - 95,115,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,152,290 - 68,200,690 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11773,710,144 - 73,758,546 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1773,710,144 - 73,758,546 (+)Ensemblpanpan1.1panPan2
Ttyh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,707,938 - 6,733,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936655205,774 - 231,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936655205,761 - 231,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTYH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,838,425 - 6,881,472 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,838,420 - 6,881,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,865,496 - 6,908,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTYH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11647,372,879 - 47,421,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1647,372,897 - 47,421,435 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607718,187,232 - 18,235,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttyh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,200,102 - 4,241,332 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,200,038 - 4,242,906 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTYH2
581 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 5 5 21 6 6 6 6 6 7 8 10 6
Below cutoff 1

Sequence


RefSeq Acc Id: ENSCAFT00000007288   ⟹   ENSCAFP00000006750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl96,120,575 - 6,156,957 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033599   ⟹   ENSCAFP00845026305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl96,792,986 - 6,829,564 (-)Ensembl
RefSeq Acc Id: XM_014116211   ⟹   XP_013971686
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.196,120,586 - 6,156,956 (-)NCBI
Dog10K_Boxer_Tasha96,742,365 - 6,778,896 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038485008   ⟹   XP_038340936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.196,833,458 - 6,870,176 (-)NCBI
RefSeq Acc Id: XM_038485009   ⟹   XP_038340937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.196,833,458 - 6,859,451 (-)NCBI
RefSeq Acc Id: XM_038546708   ⟹   XP_038402636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.096,996,992 - 7,033,550 (-)NCBI
RefSeq Acc Id: XM_038546709   ⟹   XP_038402637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.096,996,992 - 7,022,821 (-)NCBI
RefSeq Acc Id: XM_038610700   ⟹   XP_038466628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.096,936,998 - 6,973,531 (-)NCBI
RefSeq Acc Id: XM_038610701   ⟹   XP_038466629
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.096,936,998 - 6,962,812 (-)NCBI
RefSeq Acc Id: XM_038626397   ⟹   XP_038482325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha96,742,365 - 6,768,063 (-)NCBI
RefSeq Acc Id: XM_038675828   ⟹   XP_038531756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.096,792,981 - 6,829,555 (-)NCBI
RefSeq Acc Id: XM_038675829   ⟹   XP_038531757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.096,792,981 - 6,818,724 (-)NCBI
RefSeq Acc Id: XP_013971686   ⟸   XM_014116211
- Peptide Label: isoform X1
- UniProtKB: A0A8P0N788 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000006750   ⟸   ENSCAFT00000007288
RefSeq Acc Id: XP_038340936   ⟸   XM_038485008
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038340937   ⟸   XM_038485009
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038466628   ⟸   XM_038610700
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038466629   ⟸   XM_038610701
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038531756   ⟸   XM_038675828
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LEV0 (UniProtKB/TrEMBL),   A0A8I3NXW9 (UniProtKB/TrEMBL),   A0A8P0N788 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038531757   ⟸   XM_038675829
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038482325   ⟸   XM_038626397
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038402636   ⟸   XM_038546708
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LEV0 (UniProtKB/TrEMBL),   A0A8I3NXW9 (UniProtKB/TrEMBL),   A0A8P0N788 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402637   ⟸   XM_038546709
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845026305   ⟸   ENSCAFT00845033599


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004524 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845018975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007288.5 UniProtKB/TrEMBL
  ENSCAFT00000095910.1 UniProtKB/TrEMBL
  ENSCAFT00000101572.1 UniProtKB/TrEMBL
  ENSCAFT00000102164.1 UniProtKB/TrEMBL
  ENSCAFT00845033599 ENTREZGENE
  ENSCAFT00845033599.1 UniProtKB/TrEMBL
InterPro Tweety UniProtKB/TrEMBL
NCBI Gene LOC106559221 ENTREZGENE
PANTHER PROTEIN TWEETY HOMOLOG 2 UniProtKB/TrEMBL
  PTHR12424 UniProtKB/TrEMBL
Pfam Tweety UniProtKB/TrEMBL
UniProt A0A8C0LEV0 ENTREZGENE
  A0A8I3NXW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N788 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PHF0_CANLF UniProtKB/TrEMBL
  A0A8P0PJC3_CANLF UniProtKB/TrEMBL
  A0A8P0TQL2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49681 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-21 TTYH2  tweety family member 2  TTYH2  tweety family member 2  Data merged from RGD:12200166 737654 PROVISIONAL
2017-09-12 TTYH2  tweety family member 2  LOC106559221  protein tweety homolog 2-like  Symbol and/or name change 5135510 APPROVED