TRPC7 (transient receptor potential cation channel subfamily C member 7) - Rat Genome Database

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Gene: TRPC7 (transient receptor potential cation channel subfamily C member 7) Canis lupus familiaris
Analyze
Symbol: TRPC7
Name: transient receptor potential cation channel subfamily C member 7
RGD ID: 12290773
Description: ENCODES a protein that exhibits calcium channel activity (inferred); inositol 1,4,5 trisphosphate binding (inferred); store-operated calcium channel activity (inferred); INVOLVED IN calcium ion transmembrane transport (inferred); regulation of cytosolic calcium ion concentration (inferred); single fertilization (inferred); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: short transient receptor potential channel 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,113,128 - 24,256,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,859,569 - 23,003,547 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,928,881 - 25,072,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,647,009 - 23,790,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,483,142 - 23,627,149 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01124,131,869 - 24,275,920 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:15623527   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TRPC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,113,128 - 24,256,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,859,569 - 23,003,547 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,928,881 - 25,072,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,647,009 - 23,790,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,483,142 - 23,627,149 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01124,131,869 - 24,275,920 (-)NCBIUU_Cfam_GSD_1.0
TRPC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,212,745 - 136,365,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,212,745 - 136,365,545 (-)EnsemblGRCh38hg38GRCh38
GRCh375135,548,433 - 135,701,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,577,022 - 135,720,974 (-)NCBINCBI36Build 36hg18NCBI36
Build 345135,577,021 - 135,720,972NCBI
Celera5131,673,736 - 131,825,919 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,737,474 - 130,889,316 (-)NCBIHuRef
CHM1_15134,981,614 - 135,133,762 (-)NCBICHM1_1
T2T-CHM13v2.05136,735,275 - 136,888,049 (-)NCBIT2T-CHM13v2.0
Trpc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,920,911 - 57,043,778 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,920,926 - 57,043,806 (-)EnsemblGRCm39 Ensembl
GRCm381356,773,098 - 56,895,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,773,113 - 56,895,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv371356,874,469 - 56,996,949 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,782,730 - 56,905,210 (-)NCBIMGSCv36mm8
Celera1357,827,818 - 57,952,905 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.27NCBI
Trpc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,707,954 - 7,839,064 (+)NCBIGRCr8
mRatBN7.2177,708,911 - 7,833,435 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,709,583 - 7,833,435 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,728,782 - 7,851,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,261,227 - 9,383,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,725,168 - 7,847,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,134,267 - 8,280,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,135,251 - 8,279,515 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,316,554 - 10,456,609 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,660,133 - 13,781,358 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,749,821 - 13,771,093 (+)NCBI
Celera177,806,368 - 7,928,485 (+)NCBICelera
Cytogenetic Map17p14NCBI
Trpc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,261,421 - 31,416,108 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,260,767 - 31,408,852 (-)NCBIChiLan1.0ChiLan1.0
TRPC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,499,891 - 131,652,824 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,639,451 - 129,792,384 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,604,175 - 131,756,944 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,743,638 - 137,896,107 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,743,638 - 137,896,107 (-)Ensemblpanpan1.1panPan2
Trpc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,274,159 - 124,418,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,298,984 - 3,443,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,298,968 - 3,470,863 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,373,189 - 138,510,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,373,972 - 138,502,280 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,969,145 - 144,151,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,957,128 - 39,098,615 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603438,814,605 - 38,955,676 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473310,703,428 - 10,900,054 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473310,703,295 - 10,900,206 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TRPC7
1776 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 9 6 8 3
Below cutoff 5 1 5 1 6 1 2 1 6 4 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001686   ⟹   ENSCAFP00000001552
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070299   ⟹   ENSCAFP00000046737
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070479   ⟹   ENSCAFP00000046238
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000072285   ⟹   ENSCAFP00000043299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073028   ⟹   ENSCAFP00000050133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1124,113,932 - 24,252,989 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026002   ⟹   ENSCAFP00845020499
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026035   ⟹   ENSCAFP00845020528
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026046   ⟹   ENSCAFP00845020537
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026056   ⟹   ENSCAFP00845020546
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026092   ⟹   ENSCAFP00845020573
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1124,929,609 - 25,069,230 (-)Ensembl
RefSeq Acc Id: XM_038491156   ⟹   XP_038347084
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11123,647,009 - 23,790,666 (-)NCBI
RefSeq Acc Id: XM_038551660   ⟹   XP_038407588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01124,131,869 - 24,275,920 (-)NCBI
RefSeq Acc Id: XM_038615556   ⟹   XP_038471484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01123,483,142 - 23,627,149 (-)NCBI
RefSeq Acc Id: XM_038660566   ⟹   XP_038516494
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1122,859,569 - 23,003,547 (-)NCBI
RefSeq Acc Id: XM_038681050   ⟹   XP_038536978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01124,928,881 - 25,072,881 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000001552   ⟸   ENSCAFT00000001686
RefSeq Acc Id: ENSCAFP00000046238   ⟸   ENSCAFT00000070479
RefSeq Acc Id: ENSCAFP00000046737   ⟸   ENSCAFT00000070299
RefSeq Acc Id: ENSCAFP00000050133   ⟸   ENSCAFT00000073028
RefSeq Acc Id: ENSCAFP00000043299   ⟸   ENSCAFT00000072285
RefSeq Acc Id: XP_038347084   ⟸   XM_038491156
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038471484   ⟸   XM_038615556
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038536978   ⟸   XM_038681050
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K4W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516494   ⟸   XM_038660566
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K4W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038407588   ⟸   XM_038551660
- Peptide Label: isoform X1
- UniProtKB: A0A8C0K4W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020546   ⟸   ENSCAFT00845026056
RefSeq Acc Id: ENSCAFP00845020573   ⟸   ENSCAFT00845026092
RefSeq Acc Id: ENSCAFP00845020537   ⟸   ENSCAFT00845026046
RefSeq Acc Id: ENSCAFP00845020528   ⟸   ENSCAFT00845026035
RefSeq Acc Id: ENSCAFP00845020499   ⟸   ENSCAFT00845026002
Protein Domains
Transient receptor ion channel


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001103 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006433 UniProtKB/TrEMBL
  ENSCAFG00040010567 UniProtKB/TrEMBL
  ENSCAFG00845014533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001686.5 UniProtKB/TrEMBL
  ENSCAFT00000070299.2 UniProtKB/TrEMBL
  ENSCAFT00000070479.2 UniProtKB/TrEMBL
  ENSCAFT00000072285.2 UniProtKB/TrEMBL
  ENSCAFT00000073028.2 UniProtKB/TrEMBL
  ENSCAFT00030012360.1 UniProtKB/TrEMBL
  ENSCAFT00030012377.1 UniProtKB/TrEMBL
  ENSCAFT00030012390.1 UniProtKB/TrEMBL
  ENSCAFT00030012403.1 UniProtKB/TrEMBL
  ENSCAFT00040020637.1 UniProtKB/TrEMBL
  ENSCAFT00040020668.1 UniProtKB/TrEMBL
  ENSCAFT00040020704.1 UniProtKB/TrEMBL
  ENSCAFT00040020728.1 UniProtKB/TrEMBL
  ENSCAFT00845026002 ENTREZGENE
  ENSCAFT00845026002.1 UniProtKB/TrEMBL
  ENSCAFT00845026035.1 UniProtKB/TrEMBL
  ENSCAFT00845026046.1 UniProtKB/TrEMBL
  ENSCAFT00845026056.1 UniProtKB/TrEMBL
  ENSCAFT00845026092.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  TRP_dom UniProtKB/TrEMBL
  TRPC7_channel UniProtKB/TrEMBL
  TRPC_channel UniProtKB/TrEMBL
NCBI Gene TRPC7 ENTREZGENE
PANTHER PTHR10117 UniProtKB/TrEMBL
  PTHR10117:SF9 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  TRP_2 UniProtKB/TrEMBL
PRINTS TRNSRECEPTRP UniProtKB/TrEMBL
  TRPCHANNEL7 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  TRP_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A8C0K4W8 ENTREZGENE
  A0A8C0MS13_CANLF UniProtKB/TrEMBL
  A0A8C0MS34_CANLF UniProtKB/TrEMBL
  A0A8C0S948_CANLF UniProtKB/TrEMBL
  A0A8C0SA91_CANLF UniProtKB/TrEMBL
  A0A8I3NK43_CANLF UniProtKB/TrEMBL
  A0A8I3NPA8_CANLF UniProtKB/TrEMBL
  A0A8I3NUS5_CANLF UniProtKB/TrEMBL
  A0A8I3NWX2_CANLF UniProtKB/TrEMBL
  A0A8I3S0Y5_CANLF UniProtKB/TrEMBL
  A0A8P0SZ89_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:47872 ENTREZGENE