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Gene: TOP2B (DNA topoisomerase II beta) Canis lupus familiaris
Symbol: TOP2B
Name: DNA topoisomerase II beta
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (inferred); INVOLVED IN DNA topological change (inferred); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); myeloid leukemia (ortholog); prostate carcinoma in situ (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA topoisomerase 2-beta; topoisomerase (DNA) II beta; topoisomerase (DNA) II beta 180kDa
Homo sapiens (human) : TOP2B (DNA topoisomerase II beta)  HGNC  Alliance
Mus musculus (house mouse) : Top2b (topoisomerase (DNA) II beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Top2b (DNA topoisomerase II beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2b (DNA topoisomerase II beta)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2B (DNA topoisomerase II beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2b (DNA topoisomerase II beta)
Sus scrofa (pig) : TOP2B (DNA topoisomerase II beta)
Chlorocebus sabaeus (African green monkey) : TOP2B (DNA topoisomerase II beta)
Heterocephalus glaber (naked mole-rat) : Top2b (DNA topoisomerase II beta)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1 Ensembl2318,146,095 - 18,206,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12318,159,521 - 18,206,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene Ontology Annotations
Molecular Pathway Annotations


Comparative Map Data


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on TOP2B
Ensembl Gene
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 12290636
Created: 2017-01-24
Species: Canis lupus familiaris
Last Modified: 2020-02-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.