LPXN (leupaxin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: LPXN (leupaxin) Canis lupus familiaris
Analyze
Symbol: LPXN
Name: leupaxin
RGD ID: 12288582
Description: ENCODES a protein that exhibits transcription coregulator activity (ortholog); INVOLVED IN negative regulation of B cell receptor signaling pathway (ortholog); negative regulation of cell adhesion (ortholog); regulation of cell adhesion mediated by integrin (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); intellectual disability (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11837,809,612 - 37,847,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1837,810,007 - 37,847,306 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1837,348,848 - 37,384,216 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01838,465,063 - 38,506,898 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11838,064,684 - 38,100,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01837,635,355 - 37,670,733 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01838,257,644 - 38,293,024 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LPXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11837,809,612 - 37,847,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1837,810,007 - 37,847,306 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1837,348,848 - 37,384,216 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01838,465,063 - 38,506,898 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11838,064,684 - 38,100,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01837,635,355 - 37,670,733 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01838,257,644 - 38,293,024 (+)NCBIUU_Cfam_GSD_1.0
LPXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381158,526,871 - 58,578,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1158,526,871 - 58,578,220 (-)EnsemblGRCh38hg38GRCh38
GRCh371158,294,344 - 58,345,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,050,920 - 58,099,910 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,050,921 - 58,099,910NCBI
Celera1155,653,452 - 55,704,742 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1154,641,808 - 54,693,302 (-)NCBIHuRef
CHM1_11158,159,892 - 58,211,172 (-)NCBICHM1_1
T2T-CHM13v2.01158,476,376 - 58,527,888 (-)NCBIT2T-CHM13v2.0
Lpxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391912,773,251 - 12,811,177 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1912,773,557 - 12,811,171 (+)EnsemblGRCm39 Ensembl
GRCm381912,795,887 - 12,833,813 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1912,796,193 - 12,833,807 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,873,099 - 12,908,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,865,628 - 12,900,827 (+)NCBIMGSCv36mm8
Celera1913,465,696 - 13,499,415 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.73NCBI
Lpxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81219,353,319 - 219,387,743 (+)NCBIGRCr8
mRatBN7.21209,928,297 - 209,963,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1209,929,202 - 209,963,084 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1218,305,584 - 218,337,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01225,223,403 - 225,254,264 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01218,060,059 - 218,092,132 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01229,642,437 - 229,674,129 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,642,412 - 229,674,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01236,794,159 - 236,827,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,885,954 - 215,920,253 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11216,044,383 - 216,078,682 (+)NCBI
Celera1207,341,102 - 207,373,177 (+)NCBICelera
Cytogenetic Map1q43NCBI
Lpxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555113,459,378 - 3,497,416 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555113,459,521 - 3,500,181 (-)NCBIChiLan1.0ChiLan1.0
LPXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2959,658,352 - 59,742,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,714,690 - 60,769,418 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01153,781,270 - 53,832,785 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11157,242,445 - 57,294,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1157,243,028 - 57,293,442 (-)Ensemblpanpan1.1panPan2
Lpxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494713,634,695 - 13,670,669 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365813,751,277 - 3,784,503 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365813,750,819 - 3,784,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl212,540,098 - 12,582,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1212,534,780 - 12,582,756 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,200,883 - 12,213,285 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LPXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,776,434 - 14,827,095 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,779,606 - 14,827,301 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038112,105,999 - 112,152,203 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248641,818,614 - 1,852,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248641,815,056 - 1,852,041 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LPXN
418 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000012313   ⟹   ENSCAFP00000011414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1837,812,291 - 37,847,306 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000070922   ⟹   ENSCAFP00000054523
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1837,810,007 - 37,847,306 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000091989   ⟹   ENSCAFP00000055998
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1837,818,442 - 37,847,306 (+)Ensembl
RefSeq Acc Id: XM_022405387   ⟹   XP_022261095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11837,811,768 - 37,847,958 (+)NCBI
Dog10K_Boxer_Tasha1837,348,848 - 37,384,216 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038425511   ⟹   XP_038281439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01838,465,063 - 38,506,898 (+)NCBI
RefSeq Acc Id: XM_038500610   ⟹   XP_038356538
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11838,064,684 - 38,100,003 (+)NCBI
RefSeq Acc Id: XM_038563189   ⟹   XP_038419117
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01838,257,644 - 38,293,024 (+)NCBI
RefSeq Acc Id: XM_038627307   ⟹   XP_038483235
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01837,635,355 - 37,670,733 (+)NCBI
RefSeq Acc Id: XP_022261095   ⟸   XM_022405387
- Peptide Label: isoform X5
- UniProtKB: A0A8C0NLY7 (UniProtKB/TrEMBL),   A0A8P0SCW3 (UniProtKB/TrEMBL),   A0A8C0JIR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000054523   ⟸   ENSCAFT00000070922
Ensembl Acc Id: ENSCAFP00000055998   ⟸   ENSCAFT00000091989
Ensembl Acc Id: ENSCAFP00000011414   ⟸   ENSCAFT00000012313
RefSeq Acc Id: XP_038356538   ⟸   XM_038500610
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483235   ⟸   XM_038627307
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038281439   ⟸   XM_038425511
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038419117   ⟸   XM_038563189
- Peptide Label: isoform X4
- UniProtKB: A0A8C0JIR1 (UniProtKB/TrEMBL),   A0A8C0NLY7 (UniProtKB/TrEMBL),   A0A8P0SCW3 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding

Promoters
RGD ID:13686496
Promoter ID:EPDNEW_C4564
Type:single initiation site
Name:LPXN_1
Description:leupaxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11837,812,260 - 37,812,320EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007693 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017270 UniProtKB/TrEMBL
  ENSCAFG00040012337 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012313.5 UniProtKB/TrEMBL
  ENSCAFT00000091989.2 UniProtKB/TrEMBL
  ENSCAFT00030031888.1 UniProtKB/TrEMBL
  ENSCAFT00030031972.1 UniProtKB/TrEMBL
  ENSCAFT00040022940.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
InterPro Tgfb1i1/Leupaxin/TGFB1I1 UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
NCBI Gene LPXN ENTREZGENE
PANTHER FOUR AND A HALF LIM DOMAINS PROTEIN UniProtKB/TrEMBL
  LIM DOMAIN FAMILY UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
PIRSF Leupaxin UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8C0JIR1 ENTREZGENE
  A0A8C0NLY7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SED5_CANLF UniProtKB/TrEMBL
  A0A8P0SCW3 ENTREZGENE
UniProt Secondary A0A8P0SCW3 UniProtKB/TrEMBL
  A0A8P0T871 UniProtKB/TrEMBL
VGNC ID VGNC:42756 ENTREZGENE