ADAM10 (ADAM metallopeptidase domain 10) - Rat Genome Database

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Gene: ADAM10 (ADAM metallopeptidase domain 10) Canis lupus familiaris
Analyze
Symbol: ADAM10
Name: ADAM metallopeptidase domain 10
RGD ID: 12287290
Description: ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN amyloid-beta formation (ortholog); membrane protein ectodomain proteolysis (ortholog); negative regulation of gene expression (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 18 (ortholog); Bloom syndrome (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: a disintegrin and metalloprotease domain 10; ADAM 10; disintegrin and metalloproteinase domain-containing protein 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,605,724 - 23,732,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,606,517 - 23,731,823 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,577,513 - 23,704,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,770,904 - 23,899,036 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,770,904 - 23,899,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,696,156 - 23,822,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,781,555 - 23,908,752 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,923,628 - 24,051,939 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20875843   PMID:30032202  


Genomics

Comparative Map Data
ADAM10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,605,724 - 23,732,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,606,517 - 23,731,823 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,577,513 - 23,704,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,770,904 - 23,899,036 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,770,904 - 23,899,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,696,156 - 23,822,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,781,555 - 23,908,752 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,923,628 - 24,051,939 (-)NCBIUU_Cfam_GSD_1.0
ADAM10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381558,588,809 - 58,749,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1558,588,809 - 58,749,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371558,881,008 - 59,041,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,675,802 - 56,829,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 341556,676,368 - 56,829,469NCBI
Celera1535,776,749 - 35,930,110 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,711,409 - 35,864,717 (-)NCBIHuRef
CHM1_11559,006,506 - 59,160,121 (-)NCBICHM1_1
T2T-CHM13v2.01556,390,788 - 56,551,686 (-)NCBIT2T-CHM13v2.0
Adam10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,586,133 - 70,687,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,586,279 - 70,687,511 (+)EnsemblGRCm39 Ensembl
GRCm38970,678,944 - 70,780,229 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,678,997 - 70,780,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv37970,526,808 - 70,628,036 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,478,343 - 70,577,515 (+)NCBIMGSCv36mm8
Celera967,896,038 - 67,997,081 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.53NCBI
Adam10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,226,862 - 80,358,728 (+)NCBIGRCr8
mRatBN7.2871,346,008 - 71,477,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,345,837 - 71,477,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,880,624 - 77,005,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,153,639 - 75,278,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,991,371 - 73,115,716 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,107,355 - 77,237,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,107,536 - 77,237,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,842,118 - 75,974,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,200,657 - 75,289,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,307,687 - 75,310,191 (+)NCBI
Celera870,259,195 - 70,383,316 (-)NCBICelera
Cytogenetic Map8q24NCBI
Adam10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,853,366 - 15,928,200 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,853,372 - 15,927,966 (+)NCBIChiLan1.0ChiLan1.0
ADAM10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21647,857,920 - 48,011,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11552,040,227 - 52,194,225 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01537,562,930 - 37,717,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11555,873,796 - 56,027,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,873,606 - 56,027,188 (-)Ensemblpanpan1.1panPan2
Adam10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,911,860 - 102,063,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,758,118 - 19,911,759 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,760,709 - 19,911,759 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,289,209 - 113,412,798 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,289,480 - 113,407,940 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,476,146 - 125,527,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,768,827 - 24,921,169 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,768,915 - 24,919,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,399,555 - 116,551,303 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,195,755 - 13,321,823 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,195,390 - 13,321,823 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAM10
1349 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 2 17 1 6 1 6 12 2 10 6
Low 3 5 5 5 6 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022412525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038442459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038461294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038516917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038580540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038644852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB793301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB793302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB793303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB793304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000026245   ⟹   ENSCAFP00000024372
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,609,767 - 23,697,764 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061455   ⟹   ENSCAFP00000061196
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,607,798 - 23,731,781 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061503   ⟹   ENSCAFP00000063011
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,606,517 - 23,716,254 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000068607   ⟹   ENSCAFP00000048292
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,606,517 - 23,716,254 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086391   ⟹   ENSCAFP00000053342
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,607,798 - 23,731,781 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000091156   ⟹   ENSCAFP00000048379
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3023,606,517 - 23,731,823 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027829   ⟹   ENSCAFP00845021903
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,770,904 - 23,899,023 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027884   ⟹   ENSCAFP00845021949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,771,698 - 23,899,036 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027922   ⟹   ENSCAFP00845021978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,772,979 - 23,898,780 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027937   ⟹   ENSCAFP00845021990
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,772,979 - 23,898,780 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027956   ⟹   ENSCAFP00845022007
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3023,774,948 - 23,864,606 (-)Ensembl
RefSeq Acc Id: XM_038442459   ⟹   XP_038298387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03023,770,904 - 23,899,036 (-)NCBI
RefSeq Acc Id: XM_038461294   ⟹   XP_038317222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3023,577,513 - 23,704,721 (-)NCBI
RefSeq Acc Id: XM_038516917   ⟹   XP_038372845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13023,696,156 - 23,822,891 (-)NCBI
RefSeq Acc Id: XM_038580540   ⟹   XP_038436468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03023,923,628 - 24,051,939 (-)NCBI
RefSeq Acc Id: XM_038644852   ⟹   XP_038500780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03023,781,555 - 23,908,752 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000048292   ⟸   ENSCAFT00000068607
RefSeq Acc Id: ENSCAFP00000053342   ⟸   ENSCAFT00000086391
RefSeq Acc Id: ENSCAFP00000024372   ⟸   ENSCAFT00000026245
RefSeq Acc Id: ENSCAFP00000061196   ⟸   ENSCAFT00000061455
RefSeq Acc Id: ENSCAFP00000063011   ⟸   ENSCAFT00000061503
RefSeq Acc Id: ENSCAFP00000048379   ⟸   ENSCAFT00000091156
RefSeq Acc Id: XP_038372845   ⟸   XM_038516917
RefSeq Acc Id: XP_038500780   ⟸   XM_038644852
RefSeq Acc Id: XP_038298387   ⟸   XM_038442459
- UniProtKB: A0A8C0TYF2 (UniProtKB/TrEMBL),   M1VKS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317222   ⟸   XM_038461294
- UniProtKB: A0A8C0TYF2 (UniProtKB/TrEMBL),   M1VKS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436468   ⟸   XM_038580540
- UniProtKB: A0A8C0TYF2 (UniProtKB/TrEMBL),   M1VKS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022007   ⟸   ENSCAFT00845027956
RefSeq Acc Id: ENSCAFP00845021978   ⟸   ENSCAFT00845027922
RefSeq Acc Id: ENSCAFP00845021949   ⟸   ENSCAFT00845027884
RefSeq Acc Id: ENSCAFP00845021903   ⟸   ENSCAFT00845027829
RefSeq Acc Id: ENSCAFP00845021990   ⟸   ENSCAFT00845027937
Protein Domains
Disintegrin   Peptidase M12B   Peptidase M12B propeptide


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016568 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010946 UniProtKB/TrEMBL
  ENSCAFG00040025934 UniProtKB/TrEMBL
  ENSCAFG00845015520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026245.5 UniProtKB/TrEMBL
  ENSCAFT00000061455.2 UniProtKB/TrEMBL
  ENSCAFT00000061503.2 UniProtKB/TrEMBL
  ENSCAFT00000086391.2 UniProtKB/TrEMBL
  ENSCAFT00000091156.2 UniProtKB/TrEMBL
  ENSCAFT00030020476.1 UniProtKB/TrEMBL
  ENSCAFT00030020564.1 UniProtKB/TrEMBL
  ENSCAFT00030020643.1 UniProtKB/TrEMBL
  ENSCAFT00030020676.1 UniProtKB/TrEMBL
  ENSCAFT00030020709.1 UniProtKB/TrEMBL
  ENSCAFT00040048518.1 UniProtKB/TrEMBL
  ENSCAFT00040048519.1 UniProtKB/TrEMBL
  ENSCAFT00040048521.1 UniProtKB/TrEMBL
  ENSCAFT00040048523.1 UniProtKB/TrEMBL
  ENSCAFT00040048525.1 UniProtKB/TrEMBL
  ENSCAFT00040048527.1 UniProtKB/TrEMBL
  ENSCAFT00845027829 ENTREZGENE
  ENSCAFT00845027829.1 UniProtKB/TrEMBL
  ENSCAFT00845027884.1 UniProtKB/TrEMBL
  ENSCAFT00845027922.1 UniProtKB/TrEMBL
  ENSCAFT00845027937.1 UniProtKB/TrEMBL
  ENSCAFT00845027956.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM10_ADAM17 UniProtKB/TrEMBL
  ADAM10_Cys-rich UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
NCBI Gene ADAM10 ENTREZGENE
PANTHER ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER UniProtKB/TrEMBL
  PTHR45702:SF4 UniProtKB/TrEMBL
Pfam ADAM10_Cys-rich UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin_2 UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
SMART DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A8C0N215_CANLF UniProtKB/TrEMBL
  A0A8C0N3R7_CANLF UniProtKB/TrEMBL
  A0A8C0TU22_CANLF UniProtKB/TrEMBL
  A0A8C0TWI2_CANLF UniProtKB/TrEMBL
  A0A8C0TYF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z7I9_CANLF UniProtKB/TrEMBL
  A0A8I3NUR3_CANLF UniProtKB/TrEMBL
  A0A8I3NXT3_CANLF UniProtKB/TrEMBL
  A0A8I3P0M4_CANLF UniProtKB/TrEMBL
  A0A8I3S1M3_CANLF UniProtKB/TrEMBL
  A0A8I3S1M5_CANLF UniProtKB/TrEMBL
  A0A8P0T171_CANLF UniProtKB/TrEMBL
  M1V4E7_CANLF UniProtKB/TrEMBL
  M1VEH7_CANLF UniProtKB/TrEMBL
  M1VKS2 ENTREZGENE, UniProtKB/TrEMBL
  M1VPK3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:59103 ENTREZGENE