NUAK1 (NUAK family kinase 1) - Rat Genome Database

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Gene: NUAK1 (NUAK family kinase 1) Canis lupus familiaris
Analyze
Symbol: NUAK1
Name: NUAK family kinase 1
RGD ID: 12282719
Description: ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); p53 binding (inferred); INVOLVED IN intracellular signal transduction (inferred); regulation of cell adhesion (inferred); regulation of cellular senescence (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); multiple myeloma (ortholog); FOUND IN cytoplasm (inferred); fibrillar center (inferred); microtubule cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NUAK family SNF1-like kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11032,463,845 - 32,537,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1032,464,123 - 32,536,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1032,383,951 - 32,457,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01033,305,053 - 33,378,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1033,306,774 - 33,378,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,041,000 - 33,114,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01033,329,739 - 33,403,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01033,517,685 - 33,591,445 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NUAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11032,463,845 - 32,537,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1032,464,123 - 32,536,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1032,383,951 - 32,457,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01033,305,053 - 33,378,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1033,306,774 - 33,378,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,041,000 - 33,114,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01033,329,739 - 33,403,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01033,517,685 - 33,591,445 (+)NCBIUU_Cfam_GSD_1.0
NUAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812106,063,345 - 106,138,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12106,063,345 - 106,138,954 (-)EnsemblGRCh38hg38GRCh38
GRCh3712106,457,123 - 106,532,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,981,255 - 105,057,941 (-)NCBINCBI36Build 36hg18NCBI36
Celera12106,122,505 - 106,199,131 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12103,517,880 - 103,594,537 (-)NCBIHuRef
CHM1_112106,422,717 - 106,499,407 (-)NCBICHM1_1
T2T-CHM13v2.012106,026,098 - 106,101,716 (-)NCBIT2T-CHM13v2.0
Nuak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391084,206,764 - 84,282,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1084,206,769 - 84,276,461 (-)EnsemblGRCm39 Ensembl
GRCm381084,370,900 - 84,440,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1084,370,905 - 84,440,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,834,056 - 83,903,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,801,110 - 83,870,270 (-)NCBIMGSCv36mm8
Celera1086,350,008 - 86,419,314 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.42NCBI
Nuak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8721,217,729 - 21,289,608 (+)NCBIGRCr8
mRatBN7.2719,330,034 - 19,401,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl719,329,933 - 19,401,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx721,290,632 - 21,360,457 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0723,453,310 - 23,523,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0723,230,282 - 23,300,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0725,039,336 - 25,111,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl725,039,335 - 25,113,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0725,184,054 - 25,253,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4721,461,413 - 21,529,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1721,481,448 - 21,548,614 (+)NCBI
Celera716,538,758 - 16,608,089 (+)NCBICelera
Cytogenetic Map7q13NCBI
Nuak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540540,153,747 - 40,188,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540540,156,316 - 40,188,144 (-)NCBIChiLan1.0ChiLan1.0
NUAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210114,130,583 - 114,206,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112114,126,980 - 114,202,690 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012103,642,744 - 103,720,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112107,037,632 - 107,113,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12107,037,627 - 107,113,163 (-)Ensemblpanpan1.1panPan2
Nuak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494515,699,625 - 15,764,456 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364928,710,039 - 8,775,112 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364928,710,039 - 8,774,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,102,006 - 14,177,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,089,584 - 14,177,584 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2514,165,755 - 14,290,617 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111101,282,483 - 101,362,618 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11101,282,347 - 101,360,602 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037143,676,111 - 143,753,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nuak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,141,441 - 3,197,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247503,141,442 - 3,197,821 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NUAK1
877 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 6 6 4 1
Low 5 22 6 6 6 6 6 6 5
Below cutoff 8

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038680091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005332031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005365696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005400145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005414194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005433515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000002976   ⟹   ENSCAFP00000002760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1032,464,123 - 32,536,650 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046483   ⟹   ENSCAFP00000041801
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1032,465,564 - 32,536,650 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010104   ⟹   ENSCAFP00845007881
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1033,306,774 - 33,378,743 (+)Ensembl
RefSeq Acc Id: XM_022424520   ⟹   XP_022280228
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11032,463,845 - 32,537,425 (+)NCBI
Dog10K_Boxer_Tasha1032,383,951 - 32,457,600 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038488838   ⟹   XP_038344766
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,042,735 - 33,114,539 (+)NCBI
RefSeq Acc Id: XM_038488839   ⟹   XP_038344767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,041,000 - 33,114,539 (+)NCBI
RefSeq Acc Id: XM_038550802   ⟹   XP_038406730
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01033,519,448 - 33,591,445 (+)NCBI
RefSeq Acc Id: XM_038550803   ⟹   XP_038406731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01033,517,685 - 33,591,445 (+)NCBI
RefSeq Acc Id: XM_038614722   ⟹   XP_038470650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01033,331,460 - 33,403,411 (+)NCBI
RefSeq Acc Id: XM_038614723   ⟹   XP_038470651
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01033,329,739 - 33,403,411 (+)NCBI
RefSeq Acc Id: XM_038680090   ⟹   XP_038536018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01033,306,802 - 33,378,753 (+)NCBI
RefSeq Acc Id: XM_038680091   ⟹   XP_038536019
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01033,305,053 - 33,378,753 (+)NCBI
RefSeq Acc Id: XM_538417   ⟹   XP_538417
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11032,465,735 - 32,537,425 (+)NCBI
Dog10K_Boxer_Tasha1032,385,695 - 32,457,600 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005332031
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11033,042,735 - 33,114,539 (+)NCBI
RefSeq Acc Id: XR_005365696
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01033,519,448 - 33,591,445 (+)NCBI
RefSeq Acc Id: XR_005400145
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01033,331,460 - 33,403,411 (+)NCBI
RefSeq Acc Id: XR_005414194
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1032,385,695 - 32,457,600 (+)NCBI
RefSeq Acc Id: XR_005433515
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01033,306,802 - 33,378,753 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_538417   ⟸   XM_538417
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JVE7 (UniProtKB/TrEMBL),   A0A8C0S0D7 (UniProtKB/TrEMBL),   A0A8I3RUA4 (UniProtKB/TrEMBL),   A0A8C0M875 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022280228   ⟸   XM_022424520
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M875 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000002760   ⟸   ENSCAFT00000002976
RefSeq Acc Id: ENSCAFP00000041801   ⟸   ENSCAFT00000046483
RefSeq Acc Id: XP_038344767   ⟸   XM_038488839
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038344766   ⟸   XM_038488838
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470651   ⟸   XM_038614723
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038470650   ⟸   XM_038614722
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038536019   ⟸   XM_038680091
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M875 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038536018   ⟸   XM_038680090
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JVE7 (UniProtKB/TrEMBL),   A0A8C0S0D7 (UniProtKB/TrEMBL),   A0A8I3RUA4 (UniProtKB/TrEMBL),   A0A8C0M875 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406731   ⟸   XM_038550803
- Peptide Label: isoform X2
- UniProtKB: A0A8C0M875 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406730   ⟸   XM_038550802
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JVE7 (UniProtKB/TrEMBL),   A0A8C0M875 (UniProtKB/TrEMBL),   A0A8C0S0D7 (UniProtKB/TrEMBL),   A0A8I3RUA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007881   ⟸   ENSCAFT00845010104
Protein Domains
Protein kinase

Promoters
RGD ID:13685004
Promoter ID:EPDNEW_C3072
Type:initiation region
Name:NUAK1_1
Description:NUAK family kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11032,465,697 - 32,465,757EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001879 Ensembl
  ENSCAFG00000051864 UniProtKB/TrEMBL
  ENSCAFG00030003783 UniProtKB/TrEMBL
  ENSCAFG00040008084 UniProtKB/TrEMBL
  ENSCAFG00845005700 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000097423.1 UniProtKB/TrEMBL
  ENSCAFT00030007154.1 UniProtKB/TrEMBL
  ENSCAFT00040015099.1 UniProtKB/TrEMBL
  ENSCAFT00040015146.1 UniProtKB/TrEMBL
  ENSCAFT00845010104 ENTREZGENE
  ENSCAFT00845010104.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene NUAK1 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NUAK FAMILY SNF1-LIKE KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0JVE7 ENTREZGENE
  A0A8C0M875 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QPH8_CANLF UniProtKB/TrEMBL
  A0A8C0S0D7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RUA4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54977 ENTREZGENE