RGN (regucalcin) - Rat Genome Database

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Gene: RGN (regucalcin) Canis lupus familiaris
Analyze
Symbol: RGN
Name: regucalcin
RGD ID: 12280951
Description: ENCODES a protein that exhibits gluconolactonase activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); kidney development (ortholog); liver development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: regucalcin (senescence marker protein-30)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,697,292 - 40,715,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,074,578 - 15,090,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
intracellular calcium ion homeostasis  (ISO)
kidney development  (ISO)
L-ascorbic acid biosynthetic process  (IBA,IEA)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone development  (ISO)
negative regulation of calcium-dependent ATPase activity  (ISO)
negative regulation of cyclic-nucleotide phosphodiesterase activity  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA catabolic process  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of flagellated sperm motility  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of macromolecule biosynthetic process  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of RNA biosynthetic process  (ISO)
positive regulation of ATP-dependent activity  (ISO)
positive regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of phosphatase activity  (ISO)
positive regulation of proteolysis involved in protein catabolic process  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of calcium-mediated signaling  (ISO)
spermatogenesis  (ISO)

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:33652881  


Genomics

Comparative Map Data
RGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,697,292 - 40,715,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,074,578 - 15,090,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBIUU_Cfam_GSD_1.0
RGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,078,443 - 47,093,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,078,355 - 47,093,314 (+)EnsemblGRCh38hg38GRCh38
GRCh37X46,937,842 - 46,952,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,822,719 - 46,837,656 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X46,696,510 - 46,708,966NCBI
CeleraX51,129,720 - 51,148,035 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,651,176 - 44,667,384 (+)NCBIHuRef
CHM1_1X46,969,564 - 46,984,507 (+)NCBICHM1_1
T2T-CHM13v2.0X46,485,437 - 46,503,065 (+)NCBIT2T-CHM13v2.0
Rgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,413,980 - 20,428,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,416,026 - 20,428,328 (+)EnsemblGRCm39 Ensembl
GRCm38X20,549,766 - 20,562,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,549,787 - 20,562,089 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,126,944 - 20,139,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,706,777 - 19,719,046 (+)NCBIMGSCv36mm8
CeleraX18,681,357 - 18,693,626 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.04NCBI
Rgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,172,537 - 4,190,112 (-)NCBIGRCr8
mRatBN7.2X1,619,030 - 1,634,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,619,032 - 1,634,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,653,062 - 1,668,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,128,761 - 5,144,164 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,444,046 - 1,459,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,833,484 - 1,848,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,833,492 - 1,848,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,626,525 - 2,641,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,037,171 - 13,052,846NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,182,952 - 2,198,371 (-)NCBICelera
Cytogenetic MapXq11NCBI
Rgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516955,680 - 978,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516958,416 - 978,829 (-)NCBIChiLan1.0ChiLan1.0
RGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,703,675 - 48,720,753 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,707,048 - 48,724,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,513,135 - 39,530,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,371,225 - 47,388,881 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,371,226 - 47,388,881 (+)Ensemblpanpan1.1panPan2
Rgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,032,122 - 33,050,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,872,824 - 12,891,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,872,938 - 12,891,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,725,660 - 41,749,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,902,494 - 46,926,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,282,825 - 44,299,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,285,601 - 44,299,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,539,184 - 9,555,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,883,213 - 3,899,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,881,624 - 3,900,144 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RGN
158 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022416227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038449868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038523324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038523325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038523326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038587293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038587294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038587295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038651791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000036741   ⟹   ENSCAFP00000032151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000092135   ⟹   ENSCAFP00000050207
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845052737   ⟹   ENSCAFP00845041398
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845052753   ⟹   ENSCAFP00845041413
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)Ensembl
RefSeq Acc Id: XM_022416227   ⟹   XP_022271935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X40,697,292 - 40,715,491 (+)NCBI
Dog10K_Boxer_TashaX15,074,578 - 15,090,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038449866   ⟹   XP_038305794
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X40,833,056 - 40,849,916 (+)NCBI
RefSeq Acc Id: XM_038449867   ⟹   XP_038305795
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBI
RefSeq Acc Id: XM_038449868   ⟹   XP_038305796
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBI
RefSeq Acc Id: XM_038523324   ⟹   XP_038379252
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X40,820,877 - 40,837,694 (+)NCBI
RefSeq Acc Id: XM_038523325   ⟹   XP_038379253
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBI
RefSeq Acc Id: XM_038523326   ⟹   XP_038379254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBI
RefSeq Acc Id: XM_038587293   ⟹   XP_038443221
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X40,901,606 - 40,918,439 (+)NCBI
RefSeq Acc Id: XM_038587294   ⟹   XP_038443222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBI
RefSeq Acc Id: XM_038587295   ⟹   XP_038443223
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBI
RefSeq Acc Id: XM_038651789   ⟹   XP_038507717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X40,808,545 - 40,825,378 (+)NCBI
RefSeq Acc Id: XM_038651790   ⟹   XP_038507718
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBI
RefSeq Acc Id: XM_038651791   ⟹   XP_038507719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBI
RefSeq Acc Id: XP_022271935   ⟸   XM_022416227
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000050207   ⟸   ENSCAFT00000092135
Ensembl Acc Id: ENSCAFP00000032151   ⟸   ENSCAFT00000036741
RefSeq Acc Id: XP_038379254   ⟸   XM_038523326
RefSeq Acc Id: XP_038379253   ⟸   XM_038523325
RefSeq Acc Id: XP_038379252   ⟸   XM_038523324
RefSeq Acc Id: XP_038507719   ⟸   XM_038651791
RefSeq Acc Id: XP_038507718   ⟸   XM_038651790
RefSeq Acc Id: XP_038507717   ⟸   XM_038651789
RefSeq Acc Id: XP_038305796   ⟸   XM_038449868
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038305795   ⟸   XM_038449867
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038305794   ⟸   XM_038449866
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038443223   ⟸   XM_038587295
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038443222   ⟸   XM_038587294
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038443221   ⟸   XM_038587293
- UniProtKB: A0A8C0L5N4 (UniProtKB/TrEMBL),   A0A8C0SUE9 (UniProtKB/TrEMBL),   A0A8I3Q7E2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845041413   ⟸   ENSCAFT00845052753
Ensembl Acc Id: ENSCAFP00845041398   ⟸   ENSCAFT00845052737
Promoters
RGD ID:13689301
Promoter ID:EPDNEW_C7368
Type:initiation region
Name:RGN_1
Description:regucalcin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X40,698,776 - 40,698,836EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014821 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040016314 UniProtKB/TrEMBL
  ENSCAFG00845029776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000036741.4 UniProtKB/TrEMBL
  ENSCAFT00000092135.2 UniProtKB/TrEMBL
  ENSCAFT00040030104.1 UniProtKB/TrEMBL
  ENSCAFT00040030135.1 UniProtKB/TrEMBL
  ENSCAFT00845052737 ENTREZGENE
  ENSCAFT00845052737.1 UniProtKB/TrEMBL
  ENSCAFT00845052753.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  Regucalcin UniProtKB/TrEMBL
  SGL UniProtKB/TrEMBL
  SMP-30 UniProtKB/TrEMBL
NCBI Gene RGN ENTREZGENE
PANTHER REGUCALCIN UniProtKB/TrEMBL
  REGUCALCIN UniProtKB/TrEMBL
Pfam SGL UniProtKB/TrEMBL
PRINTS REGUCALCIN UniProtKB/TrEMBL
  SMP30FAMILY UniProtKB/TrEMBL
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/TrEMBL
UniProt A0A8C0L5N4 ENTREZGENE
  A0A8C0SUE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YZT8_CANLF UniProtKB/TrEMBL
  A0A8I3Q7E2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3SCF7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45516 ENTREZGENE