GRK2 (G protein-coupled receptor kinase 2) - Rat Genome Database

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Gene: GRK2 (G protein-coupled receptor kinase 2) Canis lupus familiaris
Analyze
Symbol: GRK2
Name: G protein-coupled receptor kinase 2
RGD ID: 12280453
Description: ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); delta-type opioid receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN aging (ortholog); cellular response to catecholamine stimulus (ortholog); cellular response to chemokine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH allergic contact dermatitis (ortholog); bacterial pneumonia (ortholog); Burns (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: beta-adrenergic receptor kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,148,566 - 50,167,422 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,148,598 - 50,167,428 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,758,688 - 48,777,641 (-)NCBI
ROS_Cfam_1.01851,097,619 - 51,116,589 (-)NCBI
UMICH_Zoey_3.11850,283,520 - 50,302,482 (-)NCBI
UNSW_CanFamBas_1.01849,858,001 - 49,876,975 (-)NCBI
UU_Cfam_GSD_1.01850,652,610 - 50,671,586 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cardiac muscle contraction  (IEA)
cellular response to catecholamine stimulus  (ISO)
cellular response to chemokine  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to rapamycin  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (IBA,ISO)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (IBA,ISO)
heart development  (IEA,ISO)
maintenance of protein location in nucleus  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular response to insulin stimulus  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of relaxation of smooth muscle  (IEA)
negative regulation of striated muscle contraction  (IEA)
negative regulation of the force of heart contraction by chemical signal  (IEA)
oligodendrocyte differentiation  (ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of catecholamine secretion  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of muscle cell apoptotic process  (ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (ISO)
protein phosphorylation  (IBA,IEA,ISO)
receptor internalization  (IEA)
regulation of signal transduction  (IBA)
regulation of the force of heart contraction  (IBA,ISO)
response to caloric restriction  (ISO)
response to hydrogen peroxide  (ISO)
response to leptin  (ISO)
response to morphine  (ISO)
response to muscle activity  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
signal transduction  (IEA)
tachykinin receptor signaling pathway  (IEA)
vasodilation  (ISO)
viral entry into host cell  (IEA)
viral genome replication  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:15994860   PMID:16600289   PMID:19913059  


Genomics

Comparative Map Data
GRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,148,566 - 50,167,422 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,148,598 - 50,167,428 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,758,688 - 48,777,641 (-)NCBI
ROS_Cfam_1.01851,097,619 - 51,116,589 (-)NCBI
UMICH_Zoey_3.11850,283,520 - 50,302,482 (-)NCBI
UNSW_CanFamBas_1.01849,858,001 - 49,876,975 (-)NCBI
UU_Cfam_GSD_1.01850,652,610 - 50,671,586 (-)NCBI
GRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1167,266,473 - 67,286,556 (+)EnsemblGRCh38hg38GRCh38
GRCh381167,266,420 - 67,286,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371167,033,944 - 67,054,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,790,481 - 66,810,605 (+)NCBINCBI36hg18NCBI36
Build 341166,790,668 - 66,810,945NCBI
Celera1164,377,313 - 64,386,599 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1163,362,803 - 63,382,690 (+)NCBIHuRef
CHM1_11166,912,110 - 66,937,037 (+)NCBICHM1_1
Grk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,336,027 - 4,356,350 (-)NCBIGRCm39mm39
GRCm39 Ensembl194,336,029 - 4,356,250 (-)Ensembl
GRCm38194,285,999 - 4,306,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,286,001 - 4,306,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,286,001 - 4,305,955 (-)NCBIGRCm37mm9NCBIm37
MGSCv36194,286,001 - 4,305,955 (-)NCBImm8
Celera194,157,228 - 4,177,197 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.98NCBI
Grk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21201,581,480 - 201,601,580 (-)NCBI
Rnor_6.0 Ensembl1219,536,220 - 219,544,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01219,536,220 - 219,544,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,406,333 - 226,414,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,873,002 - 206,892,868 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11207,026,454 - 207,034,564 (-)NCBI
Celera1199,125,797 - 199,145,728 (-)NCBICelera
RH 3.4 Map11560.2RGD
Cytogenetic Map1q43NCBI
Grk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,170,616 - 18,192,412 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,173,438 - 18,192,357 (-)NCBIChiLan1.0ChiLan1.0
GRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11165,939,169 - 65,959,066 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,939,164 - 65,959,066 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01162,624,647 - 62,644,846 (+)NCBIMhudiblu_PPA_v0panPan3
Grk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,994,712 - 6,013,796 (-)NCBI
SpeTri2.0NW_0049365992,437,061 - 2,456,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,209,436 - 5,227,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,209,435 - 5,227,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,992,505 - 4,000,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,975,202 - 6,995,369 (-)NCBI
ChlSab1.1 Ensembl16,975,002 - 6,995,259 (-)Ensembl
Vero_WHO_p1.0NW_023666038104,263,440 - 104,283,759 (-)NCBI
Grk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476719,212,218 - 19,231,218 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 2 12 10 6
Low 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018700   ⟹   ENSCAFP00000017324
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1850,149,646 - 50,167,428 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081314   ⟹   ENSCAFP00000050758
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1850,148,598 - 50,167,428 (-)Ensembl
RefSeq Acc Id: XM_022405600   ⟹   XP_022261308
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11850,148,566 - 50,157,394 (-)NCBI
Dog10K_Boxer_Tasha1848,758,688 - 48,767,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038424829   ⟹   XP_038280757
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01851,097,619 - 51,106,445 (-)NCBI
RefSeq Acc Id: XM_038424830   ⟹   XP_038280758
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01851,097,619 - 51,116,589 (-)NCBI
RefSeq Acc Id: XM_038501070   ⟹   XP_038356998
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11850,283,520 - 50,292,341 (-)NCBI
RefSeq Acc Id: XM_038501071   ⟹   XP_038356999
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11850,283,520 - 50,302,482 (-)NCBI
RefSeq Acc Id: XM_038563771   ⟹   XP_038419699
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01850,652,610 - 50,661,436 (-)NCBI
RefSeq Acc Id: XM_038563772   ⟹   XP_038419700
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01850,652,610 - 50,671,586 (-)NCBI
RefSeq Acc Id: XM_038627887   ⟹   XP_038483815
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01849,858,001 - 49,866,826 (-)NCBI
RefSeq Acc Id: XM_038627888   ⟹   XP_038483816
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01849,858,001 - 49,876,975 (-)NCBI
RefSeq Acc Id: XM_846992   ⟹   XP_852085
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11850,148,566 - 50,167,422 (-)NCBI
Dog10K_Boxer_Tasha1848,758,688 - 48,777,641 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_852085   ⟸   XM_846992
- Peptide Label: isoform X2
- UniProtKB: E2R5J6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022261308   ⟸   XM_022405600
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000017324   ⟸   ENSCAFT00000018700
RefSeq Acc Id: ENSCAFP00000050758   ⟸   ENSCAFT00000081314
RefSeq Acc Id: XP_038356999   ⟸   XM_038501071
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038356998   ⟸   XM_038501070
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038483816   ⟸   XM_038627888
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483815   ⟸   XM_038627887
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038280758   ⟸   XM_038424830
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038280757   ⟸   XM_038424829
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038419700   ⟸   XM_038563772
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038419699   ⟸   XM_038563771
- Peptide Label: isoform X1
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase   RGS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011733 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000017324 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000050758 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018700 UniProtKB/TrEMBL
  ENSCAFT00000081314 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PH_dom-like UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene GRK2 ENTREZGENE
Pfam PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
PRINTS GPCRKINASE UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART RGS UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A5F4C905_CANLF UniProtKB/TrEMBL
  E2R5J6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41502 ENTREZGENE