GH1 (growth hormone) - Rat Genome Database

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Pathways
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Gene: GH1 (growth hormone) Canis lupus familiaris
Analyze
Symbol: GH1
Name: growth hormone
RGD ID: 12278653
Description: ENCODES a protein that exhibits growth factor activity (inferred); growth hormone activity (inferred); growth hormone receptor binding (inferred); INVOLVED IN positive regulation of protein phosphorylation (ortholog); ASSOCIATED WITH genetic disease (ortholog); isolated growth hormone deficiency type IA (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GH; GHB1; growth hormone 1; growth hormone B1; somatotropin
RGD Orthologs
Human
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,832,265 - 11,834,123 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,832,265 - 11,834,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,791,907 - 12,793,764 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,493,565 - 13,499,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,493,571 - 13,495,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,440,328 - 12,442,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,090,131 - 15,091,987 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,092,601 - 15,094,459 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7738169   PMID:8206387   PMID:10411306   PMID:18262383   PMID:18367392   PMID:22301074   PMID:26697363   PMID:26862561   PMID:30032202   PMID:32958658  


Genomics

Comparative Map Data
GH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,832,265 - 11,834,123 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,832,265 - 11,834,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,791,907 - 12,793,764 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,493,565 - 13,499,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,493,571 - 13,495,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,440,328 - 12,442,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,090,131 - 15,091,987 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,092,601 - 15,094,459 (+)NCBIUU_Cfam_GSD_1.0
CSHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,909,608 - 63,911,258 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,909,597 - 63,911,341 (-)EnsemblGRCh38hg38GRCh38
GRCh371761,986,968 - 61,988,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,340,697 - 59,342,350 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,340,696 - 59,342,350NCBI
Celera1756,375,014 - 56,376,667 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,354,667 - 57,356,320 (-)NCBIHuRef
CHM1_11762,050,890 - 62,052,543 (-)NCBICHM1_1
T2T-CHM13v2.01764,780,351 - 64,782,005 (-)NCBIT2T-CHM13v2.0
GH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,064,909 - 15,066,696 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,064,965 - 15,066,698 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,056,362 - 15,058,095 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12p14NCBI

Variants

.
Variants in GH1
18 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 6 6
Medium 1 5 1
Low 3 1 2 5 4 1
Below cutoff 2 3 14 5 1 5 5 3 1 6 6 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF069071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF166119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM644227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT499773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT499774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT499775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U92533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z23067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000020118   ⟹   ENSCAFP00000018659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl911,832,265 - 11,834,123 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000068674   ⟹   ENSCAFP00000049437
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl911,832,365 - 11,834,123 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082480   ⟹   ENSCAFP00000043272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl911,832,265 - 11,834,123 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037520   ⟹   ENSCAFP00845029397
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl913,493,571 - 13,495,432 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037580   ⟹   ENSCAFP00845029443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl913,493,571 - 13,495,432 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845037619   ⟹   ENSCAFP00845029475
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl913,493,671 - 13,495,432 (-)Ensembl
RefSeq Acc Id: NM_001003168   ⟹   NP_001003168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1911,832,265 - 11,834,123 (-)NCBI
Dog10K_Boxer_Tasha912,791,907 - 12,793,764 (-)NCBI
ROS_Cfam_1.0913,493,571 - 13,495,432 (-)NCBI
UMICH_Zoey_3.1912,440,328 - 12,442,183 (-)NCBI
UNSW_CanFamBas_1.0915,090,131 - 15,091,987 (+)NCBI
UU_Cfam_GSD_1.0915,092,601 - 15,094,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038674955   ⟹   XP_038530883
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0913,493,565 - 13,499,392 (-)NCBI
RefSeq Acc Id: XM_038674956   ⟹   XP_038530884
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0913,493,565 - 13,499,392 (-)NCBI
RefSeq Acc Id: XM_038674957   ⟹   XP_038530885
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0913,493,565 - 13,495,515 (-)NCBI
RefSeq Acc Id: XM_038674958   ⟹   XP_038530886
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0913,493,695 - 13,495,515 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003168   ⟸   NM_001003168
- Peptide Label: precursor
- UniProtKB: Q9TQT6 (UniProtKB/Swiss-Prot),   P33711 (UniProtKB/Swiss-Prot),   A0A0M6L0Q5 (UniProtKB/TrEMBL),   A0A8C0R8H6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000018659   ⟸   ENSCAFT00000020118
RefSeq Acc Id: ENSCAFP00000049437   ⟸   ENSCAFT00000068674
RefSeq Acc Id: ENSCAFP00000043272   ⟸   ENSCAFT00000082480
RefSeq Acc Id: XP_038530884   ⟸   XM_038674956
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530883   ⟸   XM_038674955
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530885   ⟸   XM_038674957
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SZP6 (UniProtKB/TrEMBL),   A0A8I3PMN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530886   ⟸   XM_038674958
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCAFP00845029443   ⟸   ENSCAFT00845037580
RefSeq Acc Id: ENSCAFP00845029475   ⟸   ENSCAFT00845037619
RefSeq Acc Id: ENSCAFP00845029397   ⟸   ENSCAFT00845037520


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012681 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030014381 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040017587 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805006890 UniProtKB/Swiss-Prot
  ENSCAFG00845021230 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020118.2 UniProtKB/Swiss-Prot
  ENSCAFT00000068674.2 UniProtKB/TrEMBL
  ENSCAFT00000082480.2 UniProtKB/TrEMBL
  ENSCAFT00030026701.1 UniProtKB/Swiss-Prot
  ENSCAFT00030026729.1 UniProtKB/TrEMBL
  ENSCAFT00030026764.1 UniProtKB/TrEMBL
  ENSCAFT00040032741.1 UniProtKB/Swiss-Prot
  ENSCAFT00040032774.1 UniProtKB/TrEMBL
  ENSCAFT00040032796.1 UniProtKB/TrEMBL
  ENSCAFT00805012641 UniProtKB/Swiss-Prot
  ENSCAFT00845037520 ENTREZGENE
  ENSCAFT00845037520.1 UniProtKB/Swiss-Prot
  ENSCAFT00845037580 ENTREZGENE
  ENSCAFT00845037580.1 UniProtKB/TrEMBL
  ENSCAFT00845037619.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403795 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene GH1 ENTREZGENE
PANTHER PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOTROPIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0M6L0Q5 ENTREZGENE, UniProtKB/TrEMBL
  A0A7H0TZP0_CANLF UniProtKB/TrEMBL
  A0A7H0TZP1_CANLF UniProtKB/TrEMBL
  A0A7H0TZP2_CANLF UniProtKB/TrEMBL
  A0A8C0NGT0_CANLF UniProtKB/TrEMBL
  A0A8C0R8H6 ENTREZGENE
  A0A8C0SZP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PAX8_CANLF UniProtKB/TrEMBL
  A0A8I3PMN1 ENTREZGENE, UniProtKB/TrEMBL
  P33711 ENTREZGENE
  Q9TQT6 ENTREZGENE
  SOMA_CANLF UniProtKB/Swiss-Prot
UniProt Secondary Q9TQT6 UniProtKB/Swiss-Prot