RXFP2 (relaxin family peptide receptor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: RXFP2 (relaxin family peptide receptor 2) Canis lupus familiaris
Analyze
Symbol: RXFP2
Name: relaxin family peptide receptor 2
RGD ID: 12277651
Description: ENCODES a protein that exhibits peptide hormone binding (ortholog); protein-hormone receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); male gonad development (ortholog); ASSOCIATED WITH cryptorchidism (ortholog); disorder of sexual development (ortholog); genetic disease (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: INSL3 receptor; leucine-rich repeat-containing G protein-coupled receptor 8; LGR8; relaxin receptor 2; relaxin/insulin like family peptide receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,307,850 - 8,368,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,307,850 - 8,368,834 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,345,591 - 8,406,138 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0258,412,178 - 8,472,771 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,411,795 - 8,472,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,311,212 - 8,371,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,310,016 - 8,370,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,361,957 - 8,422,571 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:19585260   PMID:20450827   PMID:22301074  


Genomics

Comparative Map Data
RXFP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,307,850 - 8,368,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,307,850 - 8,368,834 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,345,591 - 8,406,138 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0258,412,178 - 8,472,771 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,411,795 - 8,472,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,311,212 - 8,371,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,310,016 - 8,370,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,361,957 - 8,422,571 (-)NCBIUU_Cfam_GSD_1.0
RXFP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381331,739,526 - 31,803,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1331,739,526 - 31,803,389 (+)EnsemblGRCh38hg38GRCh38
GRCh371332,313,663 - 32,377,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361331,211,679 - 31,275,009 (+)NCBINCBI36Build 36hg18NCBI36
Build 341331,211,678 - 31,275,009NCBI
Celera1313,380,672 - 13,444,008 (+)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1313,124,780 - 13,188,196 (+)NCBIHuRef
CHM1_11332,281,218 - 32,344,573 (+)NCBICHM1_1
T2T-CHM13v2.01330,962,734 - 31,026,637 (+)NCBIT2T-CHM13v2.0
Rxfp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,941,487 - 150,006,015 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,942,140 - 150,005,649 (+)EnsemblGRCm39 Ensembl
GRCm385150,018,675 - 150,082,550 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,018,675 - 150,082,184 (+)EnsemblGRCm38mm10GRCm38
MGSCv375150,821,250 - 150,884,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365150,287,054 - 150,349,715 (+)NCBIMGSCv36mm8
Celera5148,024,761 - 148,088,307 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.23NCBI
Rxfp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8129,961,175 - 10,023,098 (-)NCBIGRCr8
mRatBN7.2124,924,747 - 4,986,672 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl124,925,722 - 4,986,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx125,607,447 - 5,667,839 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,230,858 - 6,291,250 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,258,465 - 5,318,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,016,884 - 6,078,411 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,016,884 - 6,078,411 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,118,997 - 8,182,240 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4125,326,997 - 5,388,674 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1125,326,996 - 5,388,674 (-)NCBI
Celera126,704,247 - 6,765,055 (-)NCBICelera
Cytogenetic Map12p12NCBI
Rxfp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543114,050,694 - 14,114,902 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543114,050,537 - 14,105,852 (-)NCBIChiLan1.0ChiLan1.0
RXFP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21431,305,175 - 31,368,996 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11322,411,782 - 22,475,594 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,998,696 - 13,062,548 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11331,434,308 - 31,497,203 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1331,434,379 - 31,496,736 (+)Ensemblpanpan1.1panPan2
Rxfp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945169,463,645 - 169,526,355 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647226,425,951 - 26,487,240 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647226,425,829 - 26,487,700 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RXFP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl118,282,517 - 8,321,020 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1118,266,898 - 8,321,021 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,190,120 - 8,220,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RXFP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1310,486,993 - 10,561,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl310,489,596 - 10,556,665 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605733,799,487 - 33,869,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rxfp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247766,138,843 - 6,186,665 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247766,137,967 - 6,186,656 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RXFP2
539 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system nervous system reproductive system adipose tissue
High
Medium
Low 8
Below cutoff 1 1 7 1 5 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010501   ⟹   ENSCAFP00000009735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl258,307,850 - 8,357,326 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000044968   ⟹   ENSCAFP00000043021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl258,307,850 - 8,352,008 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000060861   ⟹   ENSCAFP00000044878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl258,307,850 - 8,368,834 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070467   ⟹   ENSCAFP00000063551
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl258,307,850 - 8,368,834 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080946   ⟹   ENSCAFP00000049980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl258,307,850 - 8,368,834 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083727   ⟹   ENSCAFP00000047078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl258,307,850 - 8,368,834 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845035419   ⟹   ENSCAFP00845027726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl258,411,795 - 8,472,893 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845035577   ⟹   ENSCAFP00845027831
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl258,411,795 - 8,456,339 (-)Ensembl
RefSeq Acc Id: NM_001005870   ⟹   NP_001005870
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1258,307,850 - 8,368,438 (-)NCBI
Dog10K_Boxer_Tasha258,345,591 - 8,406,138 (-)NCBI
ROS_Cfam_1.0258,412,178 - 8,472,771 (-)NCBI
UMICH_Zoey_3.1258,311,212 - 8,371,791 (-)NCBI
UNSW_CanFamBas_1.0258,310,016 - 8,370,508 (-)NCBI
UU_Cfam_GSD_1.0258,361,957 - 8,422,571 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001005870   ⟸   NM_001005870
- UniProtKB: Q5XM32 (UniProtKB/Swiss-Prot),   A0A8C0TTP5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000043021   ⟸   ENSCAFT00000044968
RefSeq Acc Id: ENSCAFP00000044878   ⟸   ENSCAFT00000060861
RefSeq Acc Id: ENSCAFP00000063551   ⟸   ENSCAFT00000070467
RefSeq Acc Id: ENSCAFP00000009735   ⟸   ENSCAFT00000010501
RefSeq Acc Id: ENSCAFP00000047078   ⟸   ENSCAFT00000083727
RefSeq Acc Id: ENSCAFP00000049980   ⟸   ENSCAFT00000080946
RefSeq Acc Id: ENSCAFP00845027726   ⟸   ENSCAFT00845035419
RefSeq Acc Id: ENSCAFP00845027831   ⟸   ENSCAFT00845035577
Protein Domains
G-protein coupled receptors family 1 profile   LDL-receptor class A


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006501 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030023311 UniProtKB/TrEMBL
  ENSCAFG00040025831 UniProtKB/TrEMBL
  ENSCAFG00805027771 UniProtKB/Swiss-Prot
  ENSCAFG00845019902 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010501.6 UniProtKB/Swiss-Prot
  ENSCAFT00000044968.3 UniProtKB/TrEMBL
  ENSCAFT00030043387.1 UniProtKB/TrEMBL
  ENSCAFT00030043473.1 UniProtKB/TrEMBL
  ENSCAFT00030043505.1 UniProtKB/TrEMBL
  ENSCAFT00040048338.1 UniProtKB/TrEMBL
  ENSCAFT00040048341.1 UniProtKB/TrEMBL
  ENSCAFT00040048345.1 UniProtKB/TrEMBL
  ENSCAFT00805050387 UniProtKB/Swiss-Prot
  ENSCAFT00845035419 ENTREZGENE
  ENSCAFT00845035419.1 UniProtKB/Swiss-Prot
  ENSCAFT00845035577.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Relaxin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:450220 UniProtKB/Swiss-Prot
NCBI Gene RXFP2 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RELAXIN RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RELAXINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0RS08_CANLF UniProtKB/TrEMBL
  A0A8C0TTP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TYP6_CANLF UniProtKB/TrEMBL
  A0A8C0Z7A7_CANLF UniProtKB/TrEMBL
  A0A8I3PJ05_CANLF UniProtKB/TrEMBL
  Q5XM32 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:54989 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-27 RXFP2  relaxin family peptide receptor 2    relaxin/insulin like family peptide receptor 2  Symbol and/or name change 5135510 APPROVED