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Gene: MYDGF (myeloid derived growth factor) Canis lupus familiaris

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Symbol:

MYDGF

Name:

myeloid derived growth factor

RGD ID:

12276886

Description:

INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of angiogenesis (ortholog); positive regulation of endothelial cell proliferation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Keloid (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular region (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C20H19orf10; myeloid-derived growth factor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,084,060 - 55,096,544 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,084,059 - 55,096,241 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	54,808,304 - 54,820,794 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,738,281 - 55,750,767 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	20	54,799,762 - 54,812,243 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,280,236 - 55,292,728 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,478,281 - 55,490,771 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Keloid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of endothelial cell proliferation (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

Cellular Component

endoplasmic reticulum (ISO)

extracellular region (ISO)

extracellular space (ISO)

Golgi apparatus (ISO)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

MYDGF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,084,060 - 55,096,544 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,084,059 - 55,096,241 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	54,808,304 - 54,820,794 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,738,281 - 55,750,767 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	20	54,799,762 - 54,812,243 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,280,236 - 55,292,728 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,478,281 - 55,490,771 (+)	NCBI		UU_Cfam_GSD_1.0

MYDGF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,657,545 - 4,670,342 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	4,641,374 - 4,670,362 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,657,557 - 4,670,354 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,608,557 - 4,621,415 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	4,594,232 - 4,607,089 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	4,417,713 - 4,430,528 (-)	NCBI		HuRef
CHM1_1	19	4,657,390 - 4,670,203 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,641,702 - 4,654,500 (-)	NCBI		T2T-CHM13v2.0

Mydgf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,483,541 - 56,490,920 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,482,744 - 56,490,920 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	56,176,541 - 56,183,920 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	56,175,744 - 56,183,920 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,315,964 - 56,323,343 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	55,810,250 - 55,817,629 (-)	NCBI		MGSCv36	mm8
MGSCv36	17	55,235,815 - 55,243,194 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	17	D	NCBI
cM Map	17	29.2	NCBI

Mydgf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,086,825 - 1,095,968 (-)	NCBI		GRCr8
mRatBN7.2	9	999,659 - 1,008,804 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,000,722 - 1,008,822 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,445,804 - 1,454,958 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	6,793,334 - 6,802,477 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	5,750,841 - 5,759,995 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	10,885,521 - 10,892,744 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	10,885,560 - 10,892,405 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	9,874,640 - 9,881,948 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,498,760 - 7,507,897 (+)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

Mydgf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,320,540 - 4,330,921 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,320,532 - 4,330,921 (+)	NCBI	ChiLan1.0	ChiLan1.0

MYDGF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	9,048,569 - 9,063,777 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	8,275,594 - 8,293,562 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,674,001 - 3,689,123 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,624,086 - 4,639,608 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,627,108 - 4,639,608 (-)	Ensembl	panpan1.1		panPan2

Mydgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,118,232 - 215,128,454 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,706,667 - 2,716,503 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,706,329 - 2,716,545 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYDGF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,185,060 - 74,202,301 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,185,042 - 74,202,306 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MYDGF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,382,659 - 4,389,712 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	3,786,010 - 3,798,018 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mydgf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,115,273 - 5,124,185 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,115,263 - 5,127,043 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MYDGF
156 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038429038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038504638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038567718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038631855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_849589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000030192 ⟹ ENSCAFP00000028056

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	55,084,059 - 55,096,241 (+)	Ensembl

RefSeq Acc Id:

XM_038429038 ⟹ XP_038284966

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	55,738,281 - 55,750,767 (+)	NCBI

RefSeq Acc Id:

XM_038504638 ⟹ XP_038360566

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	54,799,762 - 54,812,243 (+)	NCBI

RefSeq Acc Id:

XM_038567718 ⟹ XP_038423646

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	55,478,281 - 55,490,771 (+)	NCBI

RefSeq Acc Id:

XM_038631855 ⟹ XP_038487783

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	20	55,280,236 - 55,292,728 (+)	NCBI

RefSeq Acc Id:

XM_849589 ⟹ XP_854682

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	55,084,060 - 55,096,544 (+)	NCBI
Dog10K_Boxer_Tasha	20	54,808,304 - 54,820,794 (+)	NCBI

Sequence:

show sequence

GTCGCCGCCCCGGCCCTGCGGAGCGTTCCCAAGATGGCGGCGCCCAGCGCAAGGAGGGACGGCG
GGAGCGCGAGCTTGTGGGCTGCGTTGCTGCTGGCGGCCGTGGCGTTGAGGCCGGCGCGGGCGGT
GTCCGAGCCCACGACCGTGGCGTTTGACGTGCGACCTGGCGGCGTCGTGCACTCCTTCTCCCAG
AGCGTGGGCCCGGGGGACAAATACACTTGCGCGTTCACCTATGCTTCTCAAGGAGGGACCAACG
AGAAGTGGCAGATGAGTCTGGGGACCAGCGAAGACCACCAGCACTTCACCTGTACCATCTGGAG
GCCCCAGGGCAAGTCCTACCTGTACTTCACGCAGTTCAAGGCTGAGGTGCGGGGCGCCGAGATC
GAGTACGGCATGGCCTACTCTAAAGCTGCGTTTGAAAGAGAAAGCGATGTCCCTCTGAAAAGCG
AGGAATTTGAAGTGACCAAGACAGCAGTGTCCCACAGGCCCGGGGCGTTCAAGGCCGAGCTGTC
CAAGCTGGTGATCGTGGCCAAGGCAGCCCGCAGTGAGCTGTGACCAGGAGCCCCGCCCGGGGGC
GGCTCTTCCTCATCTCTGCTGAAGGAGCTGGGCCCAGGGAGAGCTGGCATGTTACTGGTTTTCT
AGGGGGGACTGGTTGATGTTCTCAGAACATGGAGCAAGGGTCTGAGACCCACTGCCCGTCTTTC
TTGCCAAAAGAGGCGCTGGGGCCTGTGAAGGGGCTCCCGGGGGGAATCACAGCTTCTCTGAAGC
CAGTGCGTCGTCTCCCTATGGAGCAGGCCAGGCTCCAGGTCACTCCCAGGGAGAGGAATCCTGC
TGCCCTGACCCCGAGCCAACTGTTTTCTTACAGTTTTCCCAGGGGACCTTCTTCCAGACTAACT
GGGAAGAAATTAAATGTTCTTTCACATTTAAATAAGATGGTTGAAAAGCAACCACACAGACTTG
G

hide sequence

Protein Sequences


Protein RefSeqs	XP_038284966	(Get FASTA)	NCBI Sequence Viewer
	XP_038360566	(Get FASTA)	NCBI Sequence Viewer
	XP_038423646	(Get FASTA)	NCBI Sequence Viewer
	XP_038487783	(Get FASTA)	NCBI Sequence Viewer
	XP_854682	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00030039321.1
	ENSCAFP00040008882.1

RefSeq Acc Id:	XP_854682 ⟸ XM_849589
- UniProtKB:	A0A8C0L284 (UniProtKB/TrEMBL), A0A8C0Q4R0 (UniProtKB/TrEMBL), A0A8C0L578 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAPSARRDGGSASLWAALLLAAVALRPARAVSEPTTVAFDVRPGGVVHSFSQSVGPGDKYTCA FTYASQGGTNEKWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYGMAYSKAAF ERESDVPLKSEEFEVTKTAVSHRPGAFKAELSKLVIVAKAARSEL hide sequence

Ensembl Acc Id:

ENSCAFP00000028056 ⟸ ENSCAFT00000030192

RefSeq Acc Id:

XP_038360566 ⟸ XM_038504638

RefSeq Acc Id:

XP_038487783 ⟸ XM_038631855

RefSeq Acc Id:	XP_038284966 ⟸ XM_038429038
- UniProtKB:	A0A8C0L284 (UniProtKB/TrEMBL), A0A8C0Q4R0 (UniProtKB/TrEMBL), A0A8C0L578 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038423646 ⟸ XM_038567718
- UniProtKB:	A0A8C0L284 (UniProtKB/TrEMBL), A0A8C0L578 (UniProtKB/TrEMBL), A0A8C0Q4R0 (UniProtKB/TrEMBL)

Promoters

RGD ID:

13687096

Promoter ID:

EPDNEW_C5164

Type:

multiple initiation site

Name:

MYDGF_1

Description:

myeloid derived growth factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	55,084,084 - 55,084,144	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000019008	Ensembl
	ENSCAFG00030024482	UniProtKB/TrEMBL
	ENSCAFG00040005448	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00030045034.1	UniProtKB/TrEMBL
	ENSCAFT00040010235.1	UniProtKB/TrEMBL
InterPro	MYDGF	UniProtKB/TrEMBL
KEGG Report	cfa:611866	UniProtKB/TrEMBL
NCBI Gene	MYDGF	ENTREZGENE
PANTHER	MYELOID-DERIVED GROWTH FACTOR	UniProtKB/TrEMBL
	PTHR31230	UniProtKB/TrEMBL
Pfam	UPF0556	UniProtKB/TrEMBL
UniProt	A0A8C0L284	ENTREZGENE
	A0A8C0L578	ENTREZGENE
	A0A8C0Q4R0	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:43532	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD