KLHL2 (kelch like family member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: KLHL2 (kelch like family member 2) Canis lupus familiaris
Analyze
Symbol: KLHL2
Name: kelch like family member 2
RGD ID: 12276043
Description: ENCODES a protein that exhibits actin binding (inferred); identical protein binding (inferred); ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN protein ubiquitination (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 2, Mayven; kelch-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,204,371 - 61,289,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,204,363 - 61,298,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,204,371 - 61,289,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,204,363 - 61,298,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBIUU_Cfam_GSD_1.0
KLHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384165,207,561 - 165,323,156 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4165,207,561 - 165,323,156 (+)EnsemblGRCh38hg38GRCh38
GRCh374166,128,713 - 166,244,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,348,238 - 166,463,749 (+)NCBINCBI36Build 36hg18NCBI36
Build 344166,486,395 - 166,601,903NCBI
Celera4163,459,950 - 163,579,735 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,880,568 - 161,996,120 (+)NCBIHuRef
CHM1_14166,105,246 - 166,220,767 (+)NCBICHM1_1
T2T-CHM13v2.04168,553,548 - 168,669,151 (+)NCBIT2T-CHM13v2.0
Klhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,192,707 - 65,302,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,192,709 - 65,302,669 (-)EnsemblGRCm39 Ensembl
GRCm38864,739,673 - 64,850,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,739,675 - 64,850,017 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,335,578 - 67,373,716 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36867,631,868 - 67,672,057 (-)NCBIMGSCv36mm8
Celera867,303,934 - 67,417,078 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.3NCBI
Klhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,627,171 - 29,739,782 (+)NCBIGRCr8
mRatBN7.21624,860,744 - 24,973,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,860,667 - 24,973,341 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01626,755,246 - 26,852,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,739,389 - 26,852,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,622,472 - 26,731,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,634,400 - 26,690,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11626,648,722 - 26,691,115 (+)NCBI
Celera1624,962,535 - 25,057,740 (+)NCBICelera
Cytogenetic Map16p13NCBI
Klhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540340,012,453 - 40,094,853 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540340,013,840 - 40,094,853 (-)NCBIChiLan1.0ChiLan1.0
KLHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,956,665 - 163,072,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,314,357 - 163,430,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,402,905 - 157,518,639 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,572,832 - 169,602,304 (+)NCBIpanpan1.1PanPan1.1panPan2
Klhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494317,804,579 - 17,886,216 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555684,093 - 766,006 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936555684,300 - 765,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl843,749,423 - 43,870,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1843,749,423 - 43,871,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2845,677,143 - 45,798,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,569,027 - 111,684,065 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7111,569,125 - 111,684,879 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603791,412,273 - 91,534,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475811,649,396 - 11,765,961 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475811,649,603 - 11,765,636 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHL2
1344 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 15 3 6 3 6 12 7 10 6
Low 5 7 3 3 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014062   ⟹   ENSCAFP00000013009
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,204,363 - 61,288,207 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000068729   ⟹   ENSCAFP00000059187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,204,371 - 61,298,581 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069639   ⟹   ENSCAFP00000046681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,204,363 - 61,284,221 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080069   ⟹   ENSCAFP00000045789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1561,216,676 - 61,288,207 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012505   ⟹   ENSCAFP00845009771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012541   ⟹   ENSCAFP00845009797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1562,079,193 - 62,151,392 (+)Ensembl
RefSeq Acc Id: XM_038447749   ⟹   XP_038303677
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBI
RefSeq Acc Id: XM_038496754   ⟹   XP_038352682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBI
RefSeq Acc Id: XM_038559150   ⟹   XP_038415078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBI
RefSeq Acc Id: XM_038559151   ⟹   XP_038415079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01561,697,761 - 61,770,206 (+)NCBI
RefSeq Acc Id: XM_038623099   ⟹   XP_038479027
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBI
RefSeq Acc Id: XM_038688771   ⟹   XP_038544699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000045789   ⟸   ENSCAFT00000080069
RefSeq Acc Id: ENSCAFP00000046681   ⟸   ENSCAFT00000069639
RefSeq Acc Id: ENSCAFP00000013009   ⟸   ENSCAFT00000014062
RefSeq Acc Id: ENSCAFP00000059187   ⟸   ENSCAFT00000068729
RefSeq Acc Id: XP_038352682   ⟸   XM_038496754
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479027   ⟸   XM_038623099
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038544699   ⟸   XM_038688771
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NR27 (UniProtKB/TrEMBL),   A0A8I3N4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038303677   ⟸   XM_038447749
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NR27 (UniProtKB/TrEMBL),   A0A8I3N4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415078   ⟸   XM_038559150
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NR27 (UniProtKB/TrEMBL),   A0A8I3N4S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415079   ⟸   XM_038559151
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845009771   ⟸   ENSCAFT00845012505
RefSeq Acc Id: ENSCAFP00845009797   ⟸   ENSCAFT00845012541
Protein Domains
BACK   BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008844 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017999 UniProtKB/TrEMBL
  ENSCAFG00040005869 UniProtKB/TrEMBL
  ENSCAFG00845006973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000068729.2 UniProtKB/TrEMBL
  ENSCAFT00000080069.2 UniProtKB/TrEMBL
  ENSCAFT00030033615.1 UniProtKB/TrEMBL
  ENSCAFT00030033745.1 UniProtKB/TrEMBL
  ENSCAFT00030033896.1 UniProtKB/TrEMBL
  ENSCAFT00030034027.1 UniProtKB/TrEMBL
  ENSCAFT00030034158.1 UniProtKB/TrEMBL
  ENSCAFT00040010987.1 UniProtKB/TrEMBL
  ENSCAFT00040011042.1 UniProtKB/TrEMBL
  ENSCAFT00040011097.1 UniProtKB/TrEMBL
  ENSCAFT00845012505 ENTREZGENE
  ENSCAFT00845012505.1 UniProtKB/TrEMBL
  ENSCAFT00845012541.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL2_BTB/POZ UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene KLHL2 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP Galactose oxidase, central domain UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A8C0NMH6_CANLF UniProtKB/TrEMBL
  A0A8C0NR27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NU72_CANLF UniProtKB/TrEMBL
  A0A8C0NZQ0_CANLF UniProtKB/TrEMBL
  A0A8C0Q859_CANLF UniProtKB/TrEMBL
  A0A8C0RN25_CANLF UniProtKB/TrEMBL
  A0A8C0RYN9_CANLF UniProtKB/TrEMBL
  A0A8I3N4S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTQ2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42454 ENTREZGENE