MYOT (myotilin) - Rat Genome Database

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Gene: MYOT (myotilin) Canis lupus familiaris
Analyze
Symbol: MYOT
Name: myotilin
RGD ID: 12273912
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); INVOLVED IN axon guidance (inferred); dendrite self-avoidance (inferred); homophilic cell adhesion via plasma membrane adhesion molecules (inferred); ASSOCIATED WITH atrial fibrillation (ortholog); autosomal dominant intellectual developmental disorder 31 (ortholog); cardiomyopathy (ortholog); FOUND IN Z disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,574,087 - 25,592,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,564,136 - 25,592,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,338,045 - 24,356,731 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,424,036 - 26,442,735 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,424,113 - 26,442,730 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,131,713 - 25,150,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01124,955,437 - 24,974,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,618,123 - 25,636,808 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IEA)
plasma membrane  (IEA)
Z disc  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MYOT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,574,087 - 25,592,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,564,136 - 25,592,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,338,045 - 24,356,731 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,424,036 - 26,442,735 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,424,113 - 26,442,730 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,131,713 - 25,150,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01124,955,437 - 24,974,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,618,123 - 25,636,808 (+)NCBIUU_Cfam_GSD_1.0
MYOT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385137,867,860 - 137,887,851 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5137,867,858 - 137,887,851 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,203,549 - 137,223,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,231,473 - 137,251,440 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,231,472 - 137,251,440NCBI
Celera5133,325,839 - 133,345,837 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,395,358 - 132,415,358 (+)NCBIHuRef
CHM1_15136,636,150 - 136,656,170 (+)NCBICHM1_1
T2T-CHM13v2.05138,394,286 - 138,414,287 (+)NCBIT2T-CHM13v2.0
Myot
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,467,126 - 44,488,795 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,467,141 - 44,488,791 (+)EnsemblGRCm39 Ensembl
GRCm381844,334,053 - 44,355,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,334,074 - 44,355,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,493,728 - 44,515,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,459,405 - 44,481,053 (+)NCBIMGSCv36mm8
Celera1845,713,780 - 45,735,414 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
Myot
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,956,119 - 36,975,728 (+)NCBIGRCr8
mRatBN7.21836,705,244 - 36,724,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,705,314 - 36,724,841 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,809,300 - 36,828,821 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,527,651 - 37,547,177 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,904,570 - 36,924,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01835,573,978 - 35,593,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,574,002 - 35,593,541 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl937,727,942 - 37,747,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01835,239,617 - 35,259,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41838,004,000 - 38,023,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
Myot
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540832,790,095 - 32,838,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540832,816,133 - 32,835,230 (+)NCBIChiLan1.0ChiLan1.0
MYOT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,143,300 - 133,170,336 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,282,853 - 131,309,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,254,644 - 133,274,615 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,386,101 - 139,411,960 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,386,101 - 139,411,960 (+)Ensemblpanpan1.1panPan2
Myot
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213125,805,178 - 125,822,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365974,830,027 - 4,847,421 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365974,830,111 - 4,847,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2139,861,004 - 139,919,089 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12139,899,245 - 139,919,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,621,343 - 145,642,087 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYOT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,542,153 - 40,567,873 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,548,100 - 40,568,217 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603437,323,439 - 37,340,122 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myot
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247339,130,399 - 9,160,908 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247339,131,051 - 9,160,813 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYOT
191 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 2 5
Low 3 3 16 6 2 12 8 9
Below cutoff 2 6 6 6 4 1 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003639375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005626582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038490194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038552273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038616136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038654150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038681627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038681628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038681629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000001749   ⟹   ENSCAFP00000001610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1125,574,152 - 25,592,339 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069719   ⟹   ENSCAFP00000052122
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1125,564,136 - 25,592,339 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029916   ⟹   ENSCAFP00845023491
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1126,424,113 - 26,442,730 (+)Ensembl
RefSeq Acc Id: XM_003639375   ⟹   XP_003639423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11125,574,087 - 25,592,767 (+)NCBI
Dog10K_Boxer_Tasha1124,338,045 - 24,356,731 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005626582   ⟹   XP_005626639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11125,574,087 - 25,592,767 (+)NCBI
Dog10K_Boxer_Tasha1124,338,045 - 24,356,731 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038490192   ⟹   XP_038346120
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11125,131,713 - 25,150,406 (+)NCBI
RefSeq Acc Id: XM_038490193   ⟹   XP_038346121
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11125,131,790 - 25,150,406 (+)NCBI
RefSeq Acc Id: XM_038490194   ⟹   XP_038346122
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11125,131,713 - 25,150,406 (+)NCBI
RefSeq Acc Id: XM_038552271   ⟹   XP_038408199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01125,618,123 - 25,636,808 (+)NCBI
RefSeq Acc Id: XM_038552272   ⟹   XP_038408200
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01125,618,200 - 25,636,808 (+)NCBI
RefSeq Acc Id: XM_038552273   ⟹   XP_038408201
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01125,618,123 - 25,636,808 (+)NCBI
RefSeq Acc Id: XM_038616134   ⟹   XP_038472062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01124,955,437 - 24,974,114 (+)NCBI
RefSeq Acc Id: XM_038616135   ⟹   XP_038472063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01124,955,514 - 24,974,114 (+)NCBI
RefSeq Acc Id: XM_038616136   ⟹   XP_038472064
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01124,955,437 - 24,974,114 (+)NCBI
RefSeq Acc Id: XM_038654150   ⟹   XP_038510078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1124,338,122 - 24,356,731 (+)NCBI
RefSeq Acc Id: XM_038681627   ⟹   XP_038537555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,424,036 - 26,442,735 (+)NCBI
RefSeq Acc Id: XM_038681628   ⟹   XP_038537556
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,424,113 - 26,442,735 (+)NCBI
RefSeq Acc Id: XM_038681629   ⟹   XP_038537557
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,424,036 - 26,442,735 (+)NCBI
RefSeq Acc Id: XP_005626639   ⟸   XM_005626582
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL),   A0A8C0SBP2 (UniProtKB/TrEMBL),   A0A8I3NQS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003639423   ⟸   XM_003639375
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001610   ⟸   ENSCAFT00000001749
RefSeq Acc Id: ENSCAFP00000052122   ⟸   ENSCAFT00000069719
RefSeq Acc Id: XP_038346120   ⟸   XM_038490192
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038346122   ⟸   XM_038490194
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038346121   ⟸   XM_038490193
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038472062   ⟸   XM_038616134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038472064   ⟸   XM_038616136
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038472063   ⟸   XM_038616135
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038537555   ⟸   XM_038681627
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL),   A0A8C0SBP2 (UniProtKB/TrEMBL),   A0A8I3NQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038537557   ⟸   XM_038681629
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038537556   ⟸   XM_038681628
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL),   A0A8C0SBP2 (UniProtKB/TrEMBL),   A0A8I3NQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038510078   ⟸   XM_038654150
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL),   A0A8C0SBP2 (UniProtKB/TrEMBL),   A0A8I3NQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408199   ⟸   XM_038552271
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL),   A0A8C0SBP2 (UniProtKB/TrEMBL),   A0A8I3NQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408201   ⟸   XM_038552273
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408200   ⟸   XM_038552272
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QX73 (UniProtKB/TrEMBL),   A0A8C0SBP2 (UniProtKB/TrEMBL),   A0A8I3NQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845023491   ⟸   ENSCAFT00845029916
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001140 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006102 UniProtKB/TrEMBL
  ENSCAFG00040011779 UniProtKB/TrEMBL
  ENSCAFG00845016877 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001749.5 UniProtKB/TrEMBL
  ENSCAFT00030011246.1 UniProtKB/TrEMBL
  ENSCAFT00030011285.1 UniProtKB/TrEMBL
  ENSCAFT00040021810.1 UniProtKB/TrEMBL
  ENSCAFT00845029916 ENTREZGENE
  ENSCAFT00845029916.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
NCBI Gene MYOT ENTREZGENE
PANTHER BASIGIN RELATED UniProtKB/TrEMBL
  MYOTILIN UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8C0MPG5_CANLF UniProtKB/TrEMBL
  A0A8C0QX73 ENTREZGENE
  A0A8C0SBP2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NQS6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:51746 ENTREZGENE