PCOLCE (procollagen C-endopeptidase enhancer) - Rat Genome Database

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Gene: PCOLCE (procollagen C-endopeptidase enhancer) Canis lupus familiaris
Analyze
Symbol: PCOLCE
Name: procollagen C-endopeptidase enhancer
RGD ID: 12273798
Description: ENCODES a protein that exhibits collagen binding (inferred); heparin binding (inferred); peptidase activator activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); proteolysis (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); liver cirrhosis (ortholog); FOUND IN collagen-containing extracellular matrix (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: procollagen C-endopeptidase enhancer 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,085,145 - 9,090,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,085,145 - 9,090,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,789,558 - 10,795,432 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.069,019,351 - 9,025,225 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,019,358 - 9,024,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,871,854 - 8,877,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,849,536 - 8,854,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,031,772 - 9,037,646 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PCOLCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,085,145 - 9,090,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,085,145 - 9,090,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,789,558 - 10,795,432 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.069,019,351 - 9,025,225 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,019,358 - 9,024,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,871,854 - 8,877,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,849,536 - 8,854,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,031,772 - 9,037,646 (-)NCBIUU_Cfam_GSD_1.0
PCOLCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,602,363 - 100,608,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,602,363 - 100,608,175 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,199,986 - 100,205,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,037,818 - 100,043,734 (+)NCBINCBI36Build 36hg18NCBI36
Build 34799,844,640 - 99,850,445NCBI
Celera794,929,679 - 94,935,595 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,831,551 - 94,837,467 (+)NCBIHuRef
CHM1_17100,130,452 - 100,136,368 (+)NCBICHM1_1
T2T-CHM13v2.07101,842,444 - 101,848,256 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,559,515 - 99,565,431 (+)NCBI
Pcolce
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,603,369 - 137,609,666 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,603,365 - 137,612,046 (-)EnsemblGRCm39 Ensembl
GRCm385137,605,105 - 137,611,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,605,103 - 137,613,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,046,335 - 138,052,632 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,834,897 - 137,841,156 (-)NCBIMGSCv36mm8
Celera5134,588,390 - 134,594,725 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.59NCBI
Pcolce
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,720,972 - 24,727,287 (+)NCBIGRCr8
mRatBN7.21219,084,191 - 19,090,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,084,210 - 19,090,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,239,351 - 20,245,667 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,852,235 - 20,858,548 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,916,562 - 19,922,878 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,153,995 - 22,160,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,153,983 - 22,160,337 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,171,371 - 24,177,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,672,505 - 19,678,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,662,066 - 19,668,383 (-)NCBI
Celera1220,889,573 - 20,895,889 (+)NCBICelera
Cytogenetic Map12q12NCBI
Pcolce
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573299,521 - 304,325 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573299,443 - 304,672 (-)NCBIChiLan1.0ChiLan1.0
PCOLCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,513,634 - 118,519,669 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,777,293 - 166,784,314 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,629,148 - 92,635,357 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,030,603 - 106,036,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,030,934 - 106,036,582 (+)Ensemblpanpan1.1panPan2
Pcolce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,376,625 - 133,382,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543653,824 - 659,883 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543653,844 - 659,905 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCOLCE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,523,449 - 8,528,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,523,455 - 8,528,749 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,918,291 - 7,923,587 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCOLCE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,604,552 - 12,610,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,604,526 - 12,610,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,693,856 - 3,700,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcolce
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,475,058 - 16,480,807 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,476,004 - 16,480,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PCOLCE
42 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 16 1 6 1 6 1 7 8 10 6
Low 4 6 5 5 5 5
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000022767   ⟹   ENSCAFP00000021146
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl69,085,145 - 9,090,146 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076679   ⟹   ENSCAFP00000049022
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl69,085,145 - 9,090,146 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002423   ⟹   ENSCAFP00845001924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl69,019,358 - 9,024,376 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002438   ⟹   ENSCAFP00845001937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl69,019,358 - 9,024,376 (-)Ensembl
RefSeq Acc Id: XM_038477997   ⟹   XP_038333925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.168,871,854 - 8,877,728 (-)NCBI
RefSeq Acc Id: XM_038477998   ⟹   XP_038333926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.168,871,854 - 8,877,179 (-)NCBI
RefSeq Acc Id: XM_038538456   ⟹   XP_038394384
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha610,789,558 - 10,795,432 (-)NCBI
RefSeq Acc Id: XM_038539262   ⟹   XP_038395190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,031,772 - 9,037,646 (-)NCBI
RefSeq Acc Id: XM_038539263   ⟹   XP_038395191
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,031,772 - 9,037,097 (-)NCBI
RefSeq Acc Id: XM_038603343   ⟹   XP_038459271
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,849,536 - 8,854,860 (-)NCBI
RefSeq Acc Id: XM_038668048   ⟹   XP_038523976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,019,351 - 9,025,225 (-)NCBI
RefSeq Acc Id: XM_038668049   ⟹   XP_038523977
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,019,351 - 9,024,676 (-)NCBI
RefSeq Acc Id: XM_854308   ⟹   XP_859401
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.169,085,145 - 9,090,447 (-)NCBI
Dog10K_Boxer_Tasha610,789,558 - 10,794,883 (-)NCBI
Sequence:
RefSeq Acc Id: XP_859401   ⟸   XM_854308
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R0W3 (UniProtKB/TrEMBL),   A0A8C0SJ81 (UniProtKB/TrEMBL),   A0A8I3MHG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049022   ⟸   ENSCAFT00000076679
RefSeq Acc Id: ENSCAFP00000021146   ⟸   ENSCAFT00000022767
RefSeq Acc Id: XP_038333925   ⟸   XM_038477997
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038333926   ⟸   XM_038477998
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459271   ⟸   XM_038603343
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038523976   ⟸   XM_038668048
- Peptide Label: isoform X1
- UniProtKB: A0A8C0YXT5 (UniProtKB/TrEMBL),   A0A8I3MFU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038523977   ⟸   XM_038668049
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R0W3 (UniProtKB/TrEMBL),   A0A8C0SJ81 (UniProtKB/TrEMBL),   A0A8I3MHG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394384   ⟸   XM_038538456
- Peptide Label: isoform X1
- UniProtKB: A0A8C0YXT5 (UniProtKB/TrEMBL),   A0A8I3MFU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395190   ⟸   XM_038539262
- Peptide Label: isoform X1
- UniProtKB: A0A8C0YXT5 (UniProtKB/TrEMBL),   A0A8I3MFU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395191   ⟸   XM_038539263
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R0W3 (UniProtKB/TrEMBL),   A0A8C0SJ81 (UniProtKB/TrEMBL),   A0A8I3MHG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001937   ⟸   ENSCAFT00845002438
RefSeq Acc Id: ENSCAFP00845001924   ⟸   ENSCAFT00845002423
Protein Domains
CUB   NTR

Promoters
RGD ID:13683531
Promoter ID:EPDNEW_C1598
Type:initiation region
Name:PCOLCE_1
Description:procollagen C-endopeptidase enhancer
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.169,090,183 - 9,090,243EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014322 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021205 UniProtKB/TrEMBL
  ENSCAFG00040013611 UniProtKB/TrEMBL
  ENSCAFG00845001417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022767.4 UniProtKB/TrEMBL
  ENSCAFT00000076679.2 UniProtKB/TrEMBL
  ENSCAFT00030038916.1 UniProtKB/TrEMBL
  ENSCAFT00040025142.1 UniProtKB/TrEMBL
  ENSCAFT00040025194.1 UniProtKB/TrEMBL
  ENSCAFT00845002423 ENTREZGENE
  ENSCAFT00845002423.1 UniProtKB/TrEMBL
  ENSCAFT00845002438 ENTREZGENE
  ENSCAFT00845002438.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  NTR_PCOLCE UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
NCBI Gene PCOLCE ENTREZGENE
PANTHER OVOCHYMASE-RELATED UniProtKB/TrEMBL
  PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 1 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
SMART C345C UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/TrEMBL
  SSF50242 UniProtKB/TrEMBL
UniProt A0A8C0R0W3 ENTREZGENE
  A0A8C0SJ81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YXT5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MFU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MHG0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44316 ENTREZGENE